Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for α345NC1 hexamers

Journal of Immunology

Volumn 190, Issue 4, 2013, Pages 1424-1432

  Olaru, Florina ^a   Wang, Xu Ping ^a   Luo, Wentian ^a   Ge, Linna ^a   Miner, Jeffrey H ^b   Kleinau, Sandra ^c   Geiger, Xochiquetzal J ^d   Wasiluk, Andrew ^d   Heidet, Laurence ^e   Kitching, A Richard ^f   Borza, Dorin Bogdan ^a,g  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d MAYO CLINIC   (United States)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

^f MONASH UNIVERSITY   (Australia)

^g VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; COLLAGEN TYPE 4; EPITOPE; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; TUMSTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLOMERULONEPHRITIS; HUMAN; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; COLLAGEN TYPE IV; DISEASE MODELS, ANIMAL; EPITOPES; FEMALE; HEK293 CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEOLYSIS;

EID: 84873553713     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202204     Document Type: Article

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