Strain susceptibility to active induction and passive transfer of experimental autoimmune glomerulonephritis in the rat

Nephrology Dialysis Transplantation

Volumn 21, Issue 12, 2006, Pages 3398-3408

  Reynolds, John ^a   Albouainain, Amina ^a   Duda, Mark Anthony ^a   Evans, David John ^a   Pusey, Charles Dickson ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Anti GBM antibodies; Experimental autoimmune glomerulonephritis (EAG); Genetic susceptibility; Glomerular basement membrane (GBM); Lewis (LEW) rat; Wistar Kyoto (WKY) rat

Indexed keywords

CANSTATIN; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; IMMUNOGLOBULIN G;

ALLERGIC GLOMERULONEPHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ELUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEREDITY; HYPOTHESIS; IMMUNOELECTROPHORESIS; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROSCOPY; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RAT STRAIN;

ANIMALS; AUTOIMMUNE DISEASES; GENETIC PREDISPOSITION TO DISEASE; GLOMERULONEPHRITIS; MALE; RATS; RATS, INBRED LEW; RATS, INBRED WKY;

EID: 33751412841     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl523     Document Type: Article

References (44)

1. Wilson CB, Dixon FJ. Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 1973; 3: 74-89
2. Pusey CD. Anti-glomerular basement membrane disease. Kidney Int 2003; 64: 1535-1550
3. Lerner RA, Glassock RJ, Dixon FJ. The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med 1967; 126: 989-1004
4. Saus J, Wieslander J, Langeveld JPM, Quinones S, Hudson BG. Identification of the Goodpasture antigen as the α3 chain of collagen IV. J Biol Chem 1988; 263: 13374-13380
5. Turner N, Mason PJ, Brown R et al. Molecular cloning of the human Goodpasture antigen demonstrates it to be the α3 chain of type IV collagen. J Clin Invest 1992; 89: 592-601
6. Ryan JJ, Mason PJ, Pusey CD, Turner N. Recombinant α-chains of type IV collagen demonstrate that the amino terminal of the Goodpasture antigen is critical for antibody binding. Clin Exp Immunol 1998; 113: 17-27
7. Netzer KO, Leinonen A, Boutaud A et al. The Goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. J Biol Chem 1999; 274: 11267-11274
8. Fisher M, Pusey CD, Vaughan RW, Rees AJ. Susceptibility to Goodpasture's disease is strongly associated with HLA-DRB1 genes. Kidney Int 1997; 51: 222-229
9. Phelps RG, Rees AJ. The HLA complex in Goodpasture's disease: A model for analyzing susceptibility to autoimmunity. Kidney Int 1999; 56: 1638-1653
10. Derry CJ, Ross CN, Lombardi G et al. Analysis of T cell responses to the autoantigen in Goodpasture's disease. Clin Exp Immunol 1995; 100: 262-268
11. Salama AD, Chaudhry AN, Ryan JJ et al. In Goodpasture's disease, CD4(+) T cells escape thymic deletion and are reactive with the autoantigen alpha3(IV) NC1. J Am Soc Nephrol 2001; 12: 1908-1915
12. Salama AD, Chaudhry AN, Holthaus KA et al. Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int 2003; 64: 1655-1694
13. Sado Y, Okigaki T, Takamiya H, Seno S. Experimental autoimmune glomerulonephritis with pulmonary haemorrhage in rats. The dose-effect relationship of the nephritogenic antigen from bovine glomerular basement membrane. J Clin Lab Immunol 1984; 15: 199-204
14. Sado Y, Naito I, Akita M, Okigaki T. Strain specific responses of inbred rats on the severity of experimental autoimmune glomerulonephritis. J Clin Lab Immunol 1986; 19: 193-199
15. Bolton WK, May WJ, Sturgill BC. Proliferative autoimmune glomerulonephritis in rats: A model for autoimmune glomerulonephritis in humans. Kid Int 1993; 44: 294-306
16. Reynolds J, Mavromatidis K, Cashman SJ, Evans DJ, Pusey CD. Experimental autoimmune glomerulonephritis (EAG) induced by homologous and heterologous glomerular basement membrane in two sub-strains of Wistar Kyoto rat. Nephrol Dial Transplant 1998; 13: 44-52
17. Reynolds J, Moss J, Duda MA et al. The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease. J Pathol 2003; 200: 118-129
18. Reynolds J, Cook PR, Ryan JJ et al. Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Co14a3 as a candidate gene. Exp Nephrol 2002; 10: 402-407
19. Sado Y, Boutaud AA, Kagawa M, Naito I, Ninomiya Y, Hudson BG. Induction of anti-GBM nephritis in rats by recombinant α3(IV) NC1 and α4(IV) NC1 of type IV collagen. Kidney Int 1998; 53: 664-671
20. Ryan JJ, Reynolds J, Norgan VA, Pusey CD. Expression and characterisation of recombinant rat α3(IV)NC1 and its use in the induction of experimental autoimmune glomerulonephritis. Nephrol Dial Transplant 2001; 16: 253-261
21. Steblay RW. Transfer of nephritis from sheep with autoimmune nephritis to recipient sheep by artery-to-artery cross circulation. Fed Proc 1964; 23: 449
22. Kalluri R, Danoff TM, Okada H, Neilson EG. Susceptibility to anti-glomerular basement membrane disease and Goodpasture's syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J Clin Invest 1997; 100: 2263-2275
23. Sado Y, Naito I, Okigaki T. Transfer of anti-glomerular basement membrane antibody-induced glomerulonephritis in inbred rats with isologous antibodies from urine of nephritic rats. J Pathol 1989; 158: 325-332
24. Sado Y, Kagawa M, Rauf S, Naito I, Moritoh C, Okigaki T. Isologous monoclonal antibodies can induce anti-GBM glomerulonephritis in rats. J Pathol 1992; 168: 221-227
25. Kohda T, Okada S, Hayashi A et al. High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBM nephritis. Kidney Int 2004; 66: 177-186
26. Dean EG, Wilson GRA, Li M et al. Experimental autoimmune Goodpasture's disease: A pathogenic role for both effector cells and antibody in injury. Kidney Int 2005; 67: 566-575
27. Wu J, Hicks J, Ou C, Singleton D, Borillo J, Lou YH. Glomerulonephritis induced by recombinant collagen IV alpha 3 chain noncollagen domain 1 is not associated with glomerular basement membrane antibody: A potential T cell-mediated mechanism. J Immunol 2001; 167: 2388-2395
28. Hopfer H, Maron R, Butzmann U, Helmchen U, Weiner HL, Kalluri R. The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J 2003; 17: 860-868
29. Wu J, Hicks J, Borillo J, Glass WF, Lou Y-H. CD4+ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis. J Clin Invest 2002; 109: 517-525
30. Walters G, Habib A-M, Reynolds J, Wu H, Knight JF, Pusey CD. Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vβ T cell receptor families in experimental autoimmune glomerulonephritis. Nephron Exp Nephrol 2004; 98: 71-81
31. Reynolds J, Haxby J, Juggapah J, Pusey CD. Immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis [Abstract]. J Am Soc Nephrol 2003; 14: 633
32. Bolton WK, Chen L, Hellmark T, Wieslander J, Fox J. Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen. J Am Soc Nephrol 2005; 16: 2657-2666
33. Robertson J, Wu J, Arends J et al. Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis. Kidney Int 2005; 68: 1061-1070
34. Ardends J, Wu J, Borillo J, Zhou C, Vigneswaran N, Lou Y-H. T cell epitope mimicry in antiglomerular basement membrane disease. J Immunol 2006; 176: 1252-1258
35. Reynolds J, Pusey CD. In vivo treatment with a monoclonal antibody to T helper cells in experimental autoimmune glomerulonephritis. Clin Exp Immunol 1994; 95: 122-127
36. Reynolds J, Norgan VA, Bhambra U, Smith J, Cook HT, Pusey CD. Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. J Am Soc Nephrol 2002; 13: 359-369
37. Reynolds J, Tam FWK, Chandraker A et al. CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. J Clin Invest 2000; 105: 643-651
38. Reynolds J, Khan SB, Allen AR, Benjamin CD, Pusey CD. 2Blockade of the CD154-CD40T cell costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis. Kidney Int 2004; 66: 1444-1452
39. Reynolds J, Pusey CD. Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis. J Am Soc Nephrol 2001; 12: 61-70
40. Reynolds J, Prodromidi EI, Juggapah JK et al. Nasal administration of recombinant rat α3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis. J Am Soc Nephrol 2005; 16: 1350-1359
41. Pusey CD, Holland MJ, Cashman SJ et al. Experimental autoimmune, glomerulonephritis induced by homologous and isologous glomerular basement membrane in Brown-Norway rats. Nephrol Dial Transplant 1991; 6: 457-465
42. Marriott JB, Qasim F, Reynolds J, Pusey CD, Oliveira DB. The functional affinity and specificity of autoantibodies in animal models of anti-glomerular basement membrane disease. Exp Nephrol 1995; 3: 257-264
43. Aitman TJ, Dong R, Vyse TJ et al. Copy number polymorphism in fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 2006; 439: 851-855
44. Cook PR, Evans DJ, Reynolds J, Aitman TJ, Pusey CD. Genetic analysis of experimental autoimmune glomerulonephritis [Abstract]. J Am Soc Nephrol 2004; 15: 664