Quaternary organization of the goodpasture autoantigen, the α3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intraprotomer interactions with the α4 and α5 NC1 domains

Journal of Biological Chemistry

Volumn 277, Issue 42, 2002, Pages 40075-40083

  Borza, Dorin Bogdan ^a   Bondar, Olga ^a   Todd, Parvin ^a   Sundaramoorthy, Munirathinam ^b   Sado, Yoshikazu ^a   Ninomiya, Yoshifumi ^a   Hudson, Billy G ^c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b Shigei Medical Research Institute   (Japan)

^c OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGENS; BIOLOGICAL MEMBRANES; DIMERS; DISEASES; IMMUNOLOGY;

IMMUNOCHEMICAL CHARACTERIZATION;

COLLAGEN;

AUTOANTIGEN; COLLAGEN TYPE 4; EPITOPE; MONOCLONAL ANTIBODY;

ALPORT SYNDROME; ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; GLOMERULUS BASEMENT MEMBRANE; GOODPASTURE SYNDROME; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; TRIPLE HELIX;

ANTIBODIES, MONOCLONAL; AUTOANTIGENS; BASEMENT MEMBRANE; BLOTTING, WESTERN; CELL LINE; COLLAGEN TYPE IV; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; MODELS, MOLECULAR; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

GLOMERULUS;

EID: 0037131174     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207769200     Document Type: Article

References (35)

1. Wilson, C. B., Borza, D. B., and Hudson, B. G. (2002) in The Molecular Pathology of Autoimmune Diseases (Theofilopoulos, A. N., and Bona, A. C., eds) 2nd Ed., pp. 981-1010, Gordon & Breach Science Publishers/Harwood Academic Publishers, Newark, NJ
2. Saus, J., Wieslander, J., Langeveld, J. P., Quinones, S., and Hudson, B. G. (1988) J. Biol. Chem. 263, 13374-13380
3. Netzer, K. O., Leinonen, A., Boutaud, A., Borza, D. B., Todd, P., Gunwar, S., Langeveld, J. P., and Hudson, B. G. (1999) J. Biol. Chem. 274, 11267-11274
4. Borza, D. B., Netzer, K. O., Leinonen, A., Todd, P., Cervera, J., Saus, J., and Hudson, B. G. (2000) J. Biol. Chem. 275, 6030-6037
5. Timpl, R., Wiedemann, H., van Delden, V., Furthmayr, H., and Kuhn, K. (1981) Eur. J. Biochem. 120, 203-211
6. Yurchenco, P. D., and Furthmayr, H. (1984) Biochemistry 23, 1839-1850
7. Gunwar, S., Ballester, F., Noelken, M. E., Sado, Y., Ninomiya, Y., and Hudson, B. G. (1998) J. Biol. Chem. 273, 8767-8775
8. Boutaud, A., Borza, D. B., Bondar, O., Gunwar, S., Netzer, K. O., Singh, N., Ninomiya, Y., Sado, Y., Noelken, M. E., and Hudson, B. G. (2000) J. Biol. Chem. 275, 30716-30724
9. Sundaramoorthy, M., Meiyappan, M., Todd, P., and Hudson, B. G. (2002) J. Biol. Chem. 277, 31142-31153
10. Than, M. E., Henrich, S., Huber, R., Ries, A., Mann, K., Kuhn, K., Timpl, R., Bourenkov, G. P., Bartunik, H. D., and Bode, W. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 6607-6612
11. Wieslander, J., Langeveld, J., Butkowski, R., Jodlowski, M., Noelken, M., and Hudson, B. G. (1985) J. Biol. Chem. 260, 8564-8570
12. Kalluri, R., Sun, M. J., Hudson, B. G., and Neilson, E. G. (1996) J. Biol. Chem. 271, 9062-9068
13. David, M., Borza, D. B., Leinonen, A., Belmont, J. M., and Hudson, B. G. (2001) J. Biol. Chem. 276, 6370-6377
14. Wieslander, J., Kataja, M., and Hudson, B. G. (1987) Clin. Exp. Immunol. 69, 332-340
15. Sado, Y., Boutaud, A., Kagawa, M., Naito, I., Ninomiya, Y., and Hudson, B. G. (1998) Kidney Int. 53, 664-671
16. Ninomiya, Y., Kagawa, M., Iyama, K., Naito, I., Kishiro, Y., Seyer, J. M., Sugimoto, M., Oohashi, T., and Sado, Y. (1995) J. Cell Biol. 130, 1219-1229
17. Borza, D. B., Bondar, O., Ninomiya, Y., Sado, Y., Naito, I., Todd, P., and Hudson, B. G. (2001) J. Biol. Chem. 276, 28532-28540
18. Sado, Y., Kagawa, M., Kishiro, Y., Sugihara, K., Naito, I., Seyer, J. M., Sugimoto, M., Oohashi, T., and Ninomiya, Y. (1995) Histochem. Cell Biol. 104, 267-275
19. Gunwar, S., Saus, J., Noelken, M. E., and Hudson, B. G. (1990) J. Biol. Chem. 265, 5466-5469
20. Seki, T., Naito, I., Oohashi, T., Sado, Y., and Ninomiya, Y. (1998) Histochem. Cell Biol. 110, 359-366
21. Weber, S., Dolz, R., Timpl, R., Fessler, J. H., and Engel, J. (1988) Eur. J. Biochem. 175, 229-236
22. Langeveld, J. P., Wieslander, J., Timoneda, J., McKinney, P., Butkowski, R. J., Wisdom, B. J., Jr., and Hudson, B. G. (1988) J. Biol. Chem. 263, 10481-10488
23. Timoneda, J., Gunwar, S., Monfort, G., Saus, J., Noelken, M. E., and Hudson, B. G. (1990) Connect. Tissue Res. 24, 169-186
24. Kleppel, M. M., Fan, W., Cheong, H. I., and Michael, A. F. (1992) J. Biol. Chem. 267, 4137-4142
25. Johansson, C., Butkowski, R., and Wieslander, J. (1992) J. Biol. Chem. 267, 24533-24537
26. Dolz, R., Engel, J., and Kuhn, K. (1988) Eur. J. Biochem. 178, 357-366
27. Netzer, K. O., Suzuki, K., Itoh, Y., Hudson, B. G., and Khalifah, R. G. (1998) Protein Sci. 7, 1340-1351
28. Heidet, L., Cai, Y., Guicharnaud, L., Antignac, C., and Gubler, M. C. (2000) Am. J. Pathol. 156, 1901-1910
29. Nakanishi, K., Yoskikawa, N., Iijima, K., and Nakamura, H. (1996) J. Am. Soc. Nephrol. 7, 938-945
30. Hino, S., Takemura, T., Sado, Y., Kagawa, M., Oohashi, T., Ninomiya, Y., and Yoshioka, K. (1996) Pediatr. Nephrol. 10, 742-744
31. Kashtan, C. E., Kleppel, M. M., and Gubler, M. C. (1996) Contrib. Nephrol. 117, 142-153
32. Peissel, B., Geng, L., Kalluri, R., Kashtan, C., Rennke, H. G., Gallo, G. R., Yoshioka, K., Sun, M. J., Hudson, B. G., Neilson, E. G., and Zhou, J. (1995) J. Clin. Invest. 96, 1948-1957
33. Gubler, M. C., Knebelmann, B., Beziau, A., Broyer, M., Pirson, Y., Haddoum, F., Kleppel, M. M., and Antignac, C. (1995) Kidney Int. 47, 1142-1147
34. Nomura, S., Naito, I., Fukushima, T., Tokura, T., Kataoka, N., Tanaka, I., Tanaka, H., and Osawa, G. (1998) Am. J. Kidney Dis. 31, E4
35. Hellmark, T., Burkhardt, H., and Wieslander, J. (1999) J. Biol. Chem. 274, 25862-25868