Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: Novel mechanisms for immune privilege and autoimmune pathogenesis

Journal of Biological Chemistry

Volumn 280, Issue 29, 2005, Pages 27147-27154

  Borza, Dorin Bogdan ^a   Bondart, Olga ^a   Colon, Selene ^a   Todd, Parvin ^a   Sado, Yoshikazu ^b   Neilson, Eric G ^a   Hudson, Billy G ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Shigei Medical Research Institute   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELLS; DISEASES; DISSOCIATION; GENES; IMMUNOLOGY; MEMBRANES;

CELL EPITOSE; GLOMERULAR BASEMENT MEMBRANE;

ANTIBODIES;

AUTOANTIBODY; AUTOANTIGEN; COLLAGEN TYPE 4; EPITOPE;

ANTIGEN STRUCTURE; ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULUS BASEMENT MEMBRANE; GOODPASTURE SYNDROME; HUMAN; HUMAN CELL; IMMUNE COMPLEX DEPOSITION; IMMUNOPRECIPITATION; MOLECULAR MODEL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; WESTERN BLOTTING;

ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; ANTIGEN-ANTIBODY REACTIONS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL LINE; COLLAGEN TYPE IV; DIMERIZATION; EPITOPES; HUMANS; IMMUNOASSAY; PROTEIN DENATURATION; PROTEIN STRUCTURE, QUATERNARY; TRANSFECTION;

EID: 22844441068     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504050200     Document Type: Article

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