Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence

Journal of Investigative Dermatology

Volumn 129, Issue 9, 2009, Pages 2156-2166

  Yokouchi, Mariko ^a   Saleh, Marwah Adly ^a   Kuroda, Keiko ^b   Hachiya, Takahisa ^b   Stanley, John R ^c   Amagai, Masayuki ^a   Ishii, Ken ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Medical & Biological Laboratories Co Ltd   (Japan)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOGLEIN; DESMOGLEIN ANTIBODY; EPITOPE; PEMPHIGUS ANTIBODY;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; CELL ADHESION; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; PATHOGENESIS; PEMPHIGUS; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; PRECURSOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SERUM;

EID: 70349744007     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.61     Document Type: Article

References (23)

1. Al-Amoudi A, Diez DC, Betts MJ, Frangakis AS (2007) The molecular architecture of cadherins in native epidermal desmosomes. Nature 450:832-837
2. Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP et al. (2005) Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem 280: 23778-23784
3. Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L (2002) C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296:1308-1313
4. Calkins CC, Setzer SV, Jennings JM, Summers S, Tsunoda K, Amagai M et al. (2006) Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies. J Biol Chem 281:7623-7634
5. Esaki C, Seishima M, Yamada T, Osada K, Kitajima Y (1995) Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol 105:329-333
6. Hanakawa Y, Schechter NM, Lin C, Garza L, Li H, Yamaguchi T et al. (2002) Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J Clin Invest 110:53-60
7. Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S et al. (1997) Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-ex-pressed recombinant desmogleins. J Immunol 159:2010-2017
8. Ishii K, Lin C, Siegel DL, Stanley JR (2008) Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J Invest Dermatol 128:939-948
9. Koch AW, Farooq A, Shan W, Zeng L, Colman DR, Zhou MM (2004) Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure 12:793-805
10. Muller R, Svoboda V, Wenzel E, Gebert S, Hunzelmann N, Muller HH et al. (2006) IgG reactivity against non-conformational NH-terminal epitopes of the desmoglein 3 ectodomain relates to clinical activity and phenotype of pemphigus vulgaris. Exp Dermatol 15:606-614
11. Muller R, Svoboda V, Wenzel E, Muller HH, Hertl M (2008) IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris. Exp Dermatol 17:35-43
12. Ozawa M, Kemler R (1990) Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin. J Cell Biol 111:1645-1650
13. Payne AS, Ishii K, Kacir S, Lin C, Li H, Hanakawa Y et al. (2005) Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest 115:888-899
14. Posthaus H, Dubois CM, Laprise MH, Grondin F, Suter MM, Muller E (1998) Proprotein cleavage of E-cadherin by furin in baculovirus over-expression system: potential role of other convertases in mammalian cells. FEBS Lett 438:306-310
15. Sekiguchi M, Futei Y, Fujii Y, Iwasaki T, Nishikawa T, Amagai M (2001) Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins. J Immunol 167:5439-5448
16. Sharma P, Mao X, Payne AS (2007) Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigus. J Dermatol Sci 48:1-14
17. Sharma P, Choi EJ, Kuroda K, Hachiya T, Ishii K, Payne AS. (2009) Pathogenic anti-desmoglein monoclonal antibodies demonstrate variable ELISA activity due to preferential binding of mature versus proprotein isoforms of desmoglein 3. J Invest Dermatol advance online publication 12 March 2009; doi:10.1038/jid.2009.41
18. Stanley JR, Amagai M (2006) Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med 355:1800-1810
19. Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T et al. (2003) Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol 170:2170-2178
20. Wahl JK III, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (2003) N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem 278:17269-17276
21. Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D (2006) Inhibition of Rho A activity causes pemphigus skin blistering. J Cell Biol 175:721-727
22. Williamson L, Raess NA, Caldelari R, Zakher A, de Bruin A, Posthaus H et al. (2006) Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin. Embo J 25:3298-3309
23. Yeh S, Cavacini LA, Bhol KC, Lin M, Kumar M, Duval M et al. (2006) Pathogenic human monoclonal antibody against desmoglein 3. Clin Immunol 120:68-75