메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages 111-116

Tracking replication-competent HIV reservoirs in infected individuals

Author keywords

highly active antiretroviral therapy; HIV; latency; quantitative coculture assay; viral reservoirs

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VALPROIC ACID; VIRUS DNA; VORINOSTAT;

EID: 84873457219     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0b013e32835d6e1c     Document Type: Review
Times cited : (17)

References (52)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338: 853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 0038162585 scopus 로고    scopus 로고
    • Decline in the AIDS and death rates in the EuroSIDA study: An observational study
    • Mocroft A, Ledergerber B, Katlama C, et al. Decline in the AIDS and death rates in the EuroSIDA study: An observational study. Lancet 2003; 362:22-29.
    • (2003) Lancet , vol.362 , pp. 22-29
    • Mocroft, A.1    Ledergerber, B.2    Katlama, C.3
  • 3
    • 33745222568 scopus 로고    scopus 로고
    • The survival benefits of AIDS treatment in the United States
    • Walensky RP, Paltiel AD, Losina E, et al. The survival benefits of AIDS treatment in the United States. J Infect Dis 2006; 194:11-19.
    • (2006) J Infect Dis , vol.194 , pp. 11-19
    • Walensky, R.P.1    Paltiel, A.D.2    Losina, E.3
  • 4
    • 47649115323 scopus 로고    scopus 로고
    • Life expectancy of individuals on combination antiretroviral therapy in highincome countries: A collaborative analysis of 14 cohort studies
    • Life expectancy of individuals on combination antiretroviral therapy in highincome countries: A collaborative analysis of 14 cohort studies. Lancet 2008; 372:293-299.
    • (2008) Lancet , vol.372 , pp. 293-299
  • 5
    • 77953293984 scopus 로고    scopus 로고
    • Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis
    • Donnell D, Baeten JM, Kiarie J, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis. Lancet 2010; 375:2092-2098.
    • (2010) Lancet , vol.375 , pp. 2092-2098
    • Donnell, D.1    Baeten, J.M.2    Kiarie, J.3
  • 6
    • 77954734865 scopus 로고    scopus 로고
    • Antiretroviral therapy and management of HIV infection
    • Volberding PA, Deeks SG. Antiretroviral therapy and management of HIV infection. Lancet 2010; 376:49-62.
    • (2010) Lancet , vol.376 , pp. 49-62
    • Volberding, P.A.1    Deeks, S.G.2
  • 7
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 1997; 94:13193-13197.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13193-13197
    • Chun, T.W.1    Stuyver, L.2    Mizell, S.B.3
  • 8
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 9
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong JK, Hezareh M, Gunthard HF, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997; 278:1291-1295.
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Gunthard, H.F.3
  • 10
    • 0033592967 scopus 로고    scopus 로고
    • HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    • Davey RT Jr, Bhat N, Yoder C, et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci USA 1999; 96:15109-15114.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 15109-15114
    • Davey Jr., R.T.1    Bhat, N.2    Yoder, C.3
  • 11
    • 0032991492 scopus 로고    scopus 로고
    • HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment Comet Study Group
    • Neumann AU, Tubiana R, Calvez V, et al. HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment. Comet Study Group. AIDS 1999; 13:677-683.
    • (1999) AIDS , vol.13 , pp. 677-683
    • Neumann, A.U.1    Tubiana, R.2    Calvez, V.3
  • 12
    • 0033004630 scopus 로고    scopus 로고
    • Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy
    • Harrigan PR, Whaley M, Montaner JS. Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy. AIDS 1999; 13:F59-62.
    • (1999) AIDS , vol.13
    • Harrigan, P.R.1    Whaley, M.2    Montaner, J.S.3
  • 13
    • 0032819454 scopus 로고    scopus 로고
    • Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy
    • Garcia F, Plana M, Vidal C, et al. Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy. AIDS 1999; 13:F79-86.
    • (1999) AIDS , vol.13
    • Garcia, F.1    Plana, M.2    Vidal, C.3
  • 14
    • 0033613342 scopus 로고    scopus 로고
    • Re-emergence of HIV after stopping therapy
    • Chun TW, Davey RT Jr, Engel D, et al. Re-emergence of HIV after stopping therapy. Nature 1999; 401:874-875.
    • (1999) Nature , vol.401 , pp. 874-875
    • Chun, T.W.1    Davey Jr., R.T.2    Engel, D.3
  • 15
    • 62249095476 scopus 로고    scopus 로고
    • The challenge of finding a cure for HIV infection
    • Richman DD, Margolis DM, Delaney M, et al. The challenge of finding a cure for HIV infection. Science 2009; 323:1304-1307.
    • (2009) Science , vol.323 , pp. 1304-1307
    • Richman, D.D.1    Margolis, D.M.2    Delaney, M.3
  • 16
    • 77954633050 scopus 로고    scopus 로고
    • HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals
    • Trono D, Van Lint C, Rouzioux C, et al. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science 2010; 329:174-180.
    • (2010) Science , vol.329 , pp. 174-180
    • Trono, D.1    Van Lint, C.2    Rouzioux, C.3
  • 17
    • 84862770549 scopus 로고    scopus 로고
    • HIV reservoirs: Pathogenesis and obstacles to viral eradication and cure
    • Chun TW, Fauci AS. HIV reservoirs: pathogenesis and obstacles to viral eradication and cure. AIDS 2012; 26:1261-1268.
    • (2012) AIDS , vol.26 , pp. 1261-1268
    • Chun, T.W.1    Fauci, A.S.2
  • 18
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: A global scientific strategy
    • Deeks SG, Autran B, Berkhout B, et al. Towards an HIV cure: A global scientific strategy. Nat Rev Immunol 2012; 12:607-614.
    • (2012) Nat Rev Immunol , vol.12 , pp. 607-614
    • Deeks, S.G.1    Autran, B.2    Berkhout, B.3
  • 19
    • 84864131448 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2012 recommendations of the international antiviral society-usa panel
    • Thompson MA, Aberg JA, Hoy JF, et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. Jama 2012; 308:387-402.
    • (2012) Jama , vol.308 , pp. 387-402
    • Thompson, M.A.1    Aberg, J.A.2    Hoy, J.F.3
  • 20
    • 83155181438 scopus 로고    scopus 로고
    • Evolution in the sensitivity of quantitative HIV-1 viral load tests
    • Cobb BR, Vaks JE, Do T, Vilchez RA. Evolution in the sensitivity of quantitative HIV-1 viral load tests. J Clin Virol 2011; 52 (Suppl 1):S77-S82.
    • (2011) J Clin Virol , vol.52 , Issue.SUPPL. 1
    • Cobb, B.R.1    Vaks, J.E.2    Do, T.3    Vilchez, R.A.4
  • 21
    • 79954664166 scopus 로고    scopus 로고
    • HIV cure and eradication: How will we get from the laboratory to effective clinical trials?
    • Lewin SR, Rouzioux C. HIV cure and eradication: how will we get from the laboratory to effective clinical trials? AIDS 2011; 25:885-897.
    • (2011) AIDS , vol.25 , pp. 885-897
    • Lewin, S.R.1    Rouzioux, C.2
  • 22
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
    • Chun TW, Finzi D, Margolick J, et al. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat Med 1995; 1:1284-1290.
    • (1995) Nat Med , vol.1 , pp. 1284-1290
    • Chun, T.W.1    Finzi, D.2    Margolick, J.3
  • 23
    • 84870250032 scopus 로고    scopus 로고
    • Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials
    • Mexas AM, Graf EH, Pace MJ, et al. Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials. AIDS 2012; 26:2295-2306.
    • (2012) AIDS , vol.26 , pp. 2295-2306
    • Mexas, A.M.1    Graf, E.H.2    Pace, M.J.3
  • 24
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999; 340:1614-1622.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.R.1    Callaway, D.S.2    Phair, J.P.3
  • 25
    • 84873437364 scopus 로고    scopus 로고
    • HIV qualitative PBMC macrococulture assay
    • ACTG Laboratory Technologist Committee, Version 2.0
    • ACTG Laboratory Technologist Committee. HIV qualitative PBMC macrococulture assay. ACTG Laboratory Manual 2004, Version 2.0.
    • (2004) ACTG Laboratory Manual
  • 27
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997; 387:183-188.
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1    Carruth, L.2    Finzi, D.3
  • 28
    • 24944518559 scopus 로고    scopus 로고
    • Enhanced culture assay for detection and quantitation of latently infected, resting CD4 T-cells carrying replication-competent virus in HIV-1-infected individuals
    • Siliciano JD, Siliciano RF. Enhanced culture assay for detection and quantitation of latently infected, resting CD4 T-cells carrying replication-competent virus in HIV-1-infected individuals. Methods Mol Biol 2005; 304:3-15.
    • (2005) Methods Mol Biol , vol.304 , pp. 3-15
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 29
    • 0033031218 scopus 로고    scopus 로고
    • Effect of interleukin-2 on the pool of latently infected, resting CD4 T cells in HIV-1-infected patients receiving highly active antiretroviral therapy
    • Chun TW, Engel D, Mizell SB, et al. Effect of interleukin-2 on the pool of latently infected, resting CD4 T cells in HIV-1-infected patients receiving highly active antiretroviral therapy. Nat Med 1999; 5:651-655.
    • (1999) Nat Med , vol.5 , pp. 651-655
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3
  • 30
    • 0025323391 scopus 로고
    • Microculture assay for isolation of human immunodeficiency virus type 1 and for titration of infected peripheral blood mononuclear cells
    • Dimitrov DH, Melnick JL, Hollinger FB. Microculture assay for isolation of human immunodeficiency virus type 1 and for titration of infected peripheral blood mononuclear cells. J Clin Microbiol 1990; 28:734-737.
    • (1990) J Clin Microbiol , vol.28 , pp. 734-737
    • Dimitrov, D.H.1    Melnick, J.L.2    Hollinger, F.B.3
  • 31
    • 0022967777 scopus 로고
    • CD8 lymphocytes can control HIV infection in vitro by suppressing virus replication
    • Walker CM, Moody DJ, Stites DP, Levy JA. CD8 lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986; 234:1563-1566.
    • (1986) Science , vol.234 , pp. 1563-1566
    • Walker, C.M.1    Moody, D.J.2    Stites, D.P.3    Levy, J.A.4
  • 32
    • 0035793065 scopus 로고    scopus 로고
    • Suppression of HIV replication in the resting CD4 T cell reservoir by autologous CD8 T cells: Implications for the development of therapeutic strategies
    • Chun TW, Justement JS, Moir S, et al. Suppression of HIV replication in the resting CD4 T cell reservoir by autologous CD8 T cells: Implications for the development of therapeutic strategies. Proc Natl Acad Sci USA 2001; 98:253-258.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 253-258
    • Chun, T.W.1    Justement, J.S.2    Moir, S.3
  • 33
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997; 387:188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 34
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999; 5:512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3
  • 35
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4 T cells
    • Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4 T cells. Nat Med 2003; 9:727-728.
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 36
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999; 340:1605-1613.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1    Ramratnam, B.2    Tenner-Racz, K.3
  • 37
    • 34249883292 scopus 로고    scopus 로고
    • Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus
    • Chun TW, Justement JS, Moir S, et al. Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus. J Infect Dis 2007; 195:1762-1764.
    • (2007) J Infect Dis , vol.195 , pp. 1762-1764
    • Chun, T.W.1    Justement, J.S.2    Moir, S.3
  • 38
    • 79954437524 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and HIV latency
    • Margolis DM. Histone deacetylase inhibitors and HIV latency. Curr Opin HIV AIDS 2011; 6:25-29.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 25-29
    • Margolis, D.M.1
  • 39
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: A proof-of-concept study
    • Lehrman G, Hogue IB, Palmer S, et al. Depletion of latent HIV-1 infection in vivo: A proof-of-concept study. Lancet 2005; 366:549-555.
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1    Hogue, I.B.2    Palmer, S.3
  • 40
    • 33847642822 scopus 로고    scopus 로고
    • Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
    • Siliciano JD, Lai J, Callender M, et al. Stability of the latent reservoir for HIV-1 in patients receiving valproic acid. J Infect Dis 2007; 195:833-836.
    • (2007) J Infect Dis , vol.195 , pp. 833-836
    • Siliciano, J.D.1    Lai, J.2    Callender, M.3
  • 41
    • 50949096673 scopus 로고    scopus 로고
    • Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir
    • Sagot-Lerolle N, Lamine A, Chaix ML, et al. Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir. AIDS 2008; 22:1125-1129.
    • (2008) AIDS , vol.22 , pp. 1125-1129
    • Sagot-Lerolle, N.1    Lamine, A.2    Chaix, M.L.3
  • 42
    • 50949131800 scopus 로고    scopus 로고
    • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4T cells
    • Archin NM, Eron JJ, Palmer S, et al. Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4T cells. AIDS 2008; 22:1131-1135.
    • (2008) AIDS , vol.22 , pp. 1131-1135
    • Archin, N.M.1    Eron, J.J.2    Palmer, S.3
  • 43
    • 84859424538 scopus 로고    scopus 로고
    • Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study
    • Routy JP, Tremblay CL, Angel JB, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study. HIV Med 2012; 13:291-296.
    • (2012) HIV Med , vol.13 , pp. 291-296
    • Routy, J.P.1    Tremblay, C.L.2    Angel, J.B.3
  • 44
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin NM, Liberty AL, Kashuba AD, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012; 487:482-485.
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1    Liberty, A.L.2    Kashuba, A.D.3
  • 45
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5Delta32/Delta32 stem-cell transplantation
    • Hutter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5Delta32/Delta32 stem-cell transplantation. N Engl J Med 2009; 360:692-698.
    • (2009) N Engl J Med , vol.360 , pp. 692-698
    • Hutter, G.1    Nowak, D.2    Mossner, M.3
  • 47
    • 78549235738 scopus 로고    scopus 로고
    • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: Implications for eradication
    • Chun TW, Justement JS, Murray D, et al. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: Implications for eradication. AIDS 2010; 24:2803-2808.
    • (2010) AIDS , vol.24 , pp. 2803-2808
    • Chun, T.W.1    Justement, J.S.2    Murray, D.3
  • 48
    • 10744228049 scopus 로고    scopus 로고
    • New real-time reverse transcriptaseinitiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma
    • Palmer S, Wiegand AP, Maldarelli F, et al. New real-time reverse transcriptaseinitiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol 2003; 41:4531-4536.
    • (2003) J Clin Microbiol , vol.41 , pp. 4531-4536
    • Palmer, S.1    Wiegand, A.P.2    Maldarelli, F.3
  • 49
    • 34247584237 scopus 로고    scopus 로고
    • ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia
    • Maldarelli F, Palmer S, King MS, et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathogens 2007; 3:e46.
    • (2007) PLoS Pathogens , vol.3
    • Maldarelli, F.1    Palmer, S.2    King, M.S.3
  • 50
    • 41649083599 scopus 로고    scopus 로고
    • Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
    • Palmer S, Maldarelli F, Wiegand A, et al. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 2008; 105:3879-3884.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3879-3884
    • Palmer, S.1    Maldarelli, F.2    Wiegand, A.3
  • 51
    • 27644524761 scopus 로고    scopus 로고
    • HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun TW, Nickle DC, Justement JS, et al. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J Clin Invest 2005; 115:3250-3255.
    • (2005) J Clin Invest , vol.115 , pp. 3250-3255
    • Chun, T.W.1    Nickle, D.C.2    Justement, J.S.3
  • 52
    • 79957966626 scopus 로고    scopus 로고
    • Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy
    • Chun TW, Murray D, Justement JS, et al. Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis 2011; 204:135-138.
    • (2011) J Infect Dis , vol.204 , pp. 135-138
    • Chun, T.W.1    Murray, D.2    Justement, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.