-
1
-
-
2642709177
-
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
-
HIV Outpatient Study Investigators
-
Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338: 853-860.
-
(1998)
N Engl J Med
, vol.338
, pp. 853-860
-
-
Palella Jr., F.J.1
Delaney, K.M.2
Moorman, A.C.3
-
2
-
-
0038162585
-
Decline in the AIDS and death rates in the EuroSIDA study: An observational study
-
Mocroft A, Ledergerber B, Katlama C, et al. Decline in the AIDS and death rates in the EuroSIDA study: An observational study. Lancet 2003; 362:22-29.
-
(2003)
Lancet
, vol.362
, pp. 22-29
-
-
Mocroft, A.1
Ledergerber, B.2
Katlama, C.3
-
3
-
-
33745222568
-
The survival benefits of AIDS treatment in the United States
-
Walensky RP, Paltiel AD, Losina E, et al. The survival benefits of AIDS treatment in the United States. J Infect Dis 2006; 194:11-19.
-
(2006)
J Infect Dis
, vol.194
, pp. 11-19
-
-
Walensky, R.P.1
Paltiel, A.D.2
Losina, E.3
-
4
-
-
47649115323
-
Life expectancy of individuals on combination antiretroviral therapy in highincome countries: A collaborative analysis of 14 cohort studies
-
Life expectancy of individuals on combination antiretroviral therapy in highincome countries: A collaborative analysis of 14 cohort studies. Lancet 2008; 372:293-299.
-
(2008)
Lancet
, vol.372
, pp. 293-299
-
-
-
5
-
-
77953293984
-
Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis
-
Donnell D, Baeten JM, Kiarie J, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis. Lancet 2010; 375:2092-2098.
-
(2010)
Lancet
, vol.375
, pp. 2092-2098
-
-
Donnell, D.1
Baeten, J.M.2
Kiarie, J.3
-
6
-
-
77954734865
-
Antiretroviral therapy and management of HIV infection
-
Volberding PA, Deeks SG. Antiretroviral therapy and management of HIV infection. Lancet 2010; 376:49-62.
-
(2010)
Lancet
, vol.376
, pp. 49-62
-
-
Volberding, P.A.1
Deeks, S.G.2
-
7
-
-
0030659177
-
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
-
Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 1997; 94:13193-13197.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13193-13197
-
-
Chun, T.W.1
Stuyver, L.2
Mizell, S.B.3
-
8
-
-
14444273439
-
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
-
Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278:1295-1300.
-
(1997)
Science
, vol.278
, pp. 1295-1300
-
-
Finzi, D.1
Hermankova, M.2
Pierson, T.3
-
9
-
-
0030712305
-
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
-
Wong JK, Hezareh M, Gunthard HF, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997; 278:1291-1295.
-
(1997)
Science
, vol.278
, pp. 1291-1295
-
-
Wong, J.K.1
Hezareh, M.2
Gunthard, H.F.3
-
10
-
-
0033592967
-
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
-
Davey RT Jr, Bhat N, Yoder C, et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci USA 1999; 96:15109-15114.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 15109-15114
-
-
Davey Jr., R.T.1
Bhat, N.2
Yoder, C.3
-
11
-
-
0032991492
-
HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment Comet Study Group
-
Neumann AU, Tubiana R, Calvez V, et al. HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment. Comet Study Group. AIDS 1999; 13:677-683.
-
(1999)
AIDS
, vol.13
, pp. 677-683
-
-
Neumann, A.U.1
Tubiana, R.2
Calvez, V.3
-
12
-
-
0033004630
-
Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy
-
Harrigan PR, Whaley M, Montaner JS. Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy. AIDS 1999; 13:F59-62.
-
(1999)
AIDS
, vol.13
-
-
Harrigan, P.R.1
Whaley, M.2
Montaner, J.S.3
-
13
-
-
0032819454
-
Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy
-
Garcia F, Plana M, Vidal C, et al. Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy. AIDS 1999; 13:F79-86.
-
(1999)
AIDS
, vol.13
-
-
Garcia, F.1
Plana, M.2
Vidal, C.3
-
14
-
-
0033613342
-
Re-emergence of HIV after stopping therapy
-
Chun TW, Davey RT Jr, Engel D, et al. Re-emergence of HIV after stopping therapy. Nature 1999; 401:874-875.
-
(1999)
Nature
, vol.401
, pp. 874-875
-
-
Chun, T.W.1
Davey Jr., R.T.2
Engel, D.3
-
15
-
-
62249095476
-
The challenge of finding a cure for HIV infection
-
Richman DD, Margolis DM, Delaney M, et al. The challenge of finding a cure for HIV infection. Science 2009; 323:1304-1307.
-
(2009)
Science
, vol.323
, pp. 1304-1307
-
-
Richman, D.D.1
Margolis, D.M.2
Delaney, M.3
-
16
-
-
77954633050
-
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals
-
Trono D, Van Lint C, Rouzioux C, et al. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science 2010; 329:174-180.
-
(2010)
Science
, vol.329
, pp. 174-180
-
-
Trono, D.1
Van Lint, C.2
Rouzioux, C.3
-
17
-
-
84862770549
-
HIV reservoirs: Pathogenesis and obstacles to viral eradication and cure
-
Chun TW, Fauci AS. HIV reservoirs: pathogenesis and obstacles to viral eradication and cure. AIDS 2012; 26:1261-1268.
-
(2012)
AIDS
, vol.26
, pp. 1261-1268
-
-
Chun, T.W.1
Fauci, A.S.2
-
18
-
-
84864345953
-
Towards an HIV cure: A global scientific strategy
-
Deeks SG, Autran B, Berkhout B, et al. Towards an HIV cure: A global scientific strategy. Nat Rev Immunol 2012; 12:607-614.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 607-614
-
-
Deeks, S.G.1
Autran, B.2
Berkhout, B.3
-
19
-
-
84864131448
-
Antiretroviral treatment of adult HIV infection: 2012 recommendations of the international antiviral society-usa panel
-
Thompson MA, Aberg JA, Hoy JF, et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. Jama 2012; 308:387-402.
-
(2012)
Jama
, vol.308
, pp. 387-402
-
-
Thompson, M.A.1
Aberg, J.A.2
Hoy, J.F.3
-
20
-
-
83155181438
-
Evolution in the sensitivity of quantitative HIV-1 viral load tests
-
Cobb BR, Vaks JE, Do T, Vilchez RA. Evolution in the sensitivity of quantitative HIV-1 viral load tests. J Clin Virol 2011; 52 (Suppl 1):S77-S82.
-
(2011)
J Clin Virol
, vol.52
, Issue.SUPPL. 1
-
-
Cobb, B.R.1
Vaks, J.E.2
Do, T.3
Vilchez, R.A.4
-
21
-
-
79954664166
-
HIV cure and eradication: How will we get from the laboratory to effective clinical trials?
-
Lewin SR, Rouzioux C. HIV cure and eradication: how will we get from the laboratory to effective clinical trials? AIDS 2011; 25:885-897.
-
(2011)
AIDS
, vol.25
, pp. 885-897
-
-
Lewin, S.R.1
Rouzioux, C.2
-
22
-
-
0028792184
-
In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
-
Chun TW, Finzi D, Margolick J, et al. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat Med 1995; 1:1284-1290.
-
(1995)
Nat Med
, vol.1
, pp. 1284-1290
-
-
Chun, T.W.1
Finzi, D.2
Margolick, J.3
-
23
-
-
84870250032
-
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials
-
Mexas AM, Graf EH, Pace MJ, et al. Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials. AIDS 2012; 26:2295-2306.
-
(2012)
AIDS
, vol.26
, pp. 2295-2306
-
-
Mexas, A.M.1
Graf, E.H.2
Pace, M.J.3
-
24
-
-
0033609374
-
Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
-
Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999; 340:1614-1622.
-
(1999)
N Engl J Med
, vol.340
, pp. 1614-1622
-
-
Furtado, M.R.1
Callaway, D.S.2
Phair, J.P.3
-
25
-
-
84873437364
-
HIV qualitative PBMC macrococulture assay
-
ACTG Laboratory Technologist Committee, Version 2.0
-
ACTG Laboratory Technologist Committee. HIV qualitative PBMC macrococulture assay. ACTG Laboratory Manual 2004, Version 2.0.
-
(2004)
ACTG Laboratory Manual
-
-
-
27
-
-
0030913366
-
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
-
Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997; 387:183-188.
-
(1997)
Nature
, vol.387
, pp. 183-188
-
-
Chun, T.W.1
Carruth, L.2
Finzi, D.3
-
28
-
-
24944518559
-
Enhanced culture assay for detection and quantitation of latently infected, resting CD4 T-cells carrying replication-competent virus in HIV-1-infected individuals
-
Siliciano JD, Siliciano RF. Enhanced culture assay for detection and quantitation of latently infected, resting CD4 T-cells carrying replication-competent virus in HIV-1-infected individuals. Methods Mol Biol 2005; 304:3-15.
-
(2005)
Methods Mol Biol
, vol.304
, pp. 3-15
-
-
Siliciano, J.D.1
Siliciano, R.F.2
-
29
-
-
0033031218
-
Effect of interleukin-2 on the pool of latently infected, resting CD4 T cells in HIV-1-infected patients receiving highly active antiretroviral therapy
-
Chun TW, Engel D, Mizell SB, et al. Effect of interleukin-2 on the pool of latently infected, resting CD4 T cells in HIV-1-infected patients receiving highly active antiretroviral therapy. Nat Med 1999; 5:651-655.
-
(1999)
Nat Med
, vol.5
, pp. 651-655
-
-
Chun, T.W.1
Engel, D.2
Mizell, S.B.3
-
30
-
-
0025323391
-
Microculture assay for isolation of human immunodeficiency virus type 1 and for titration of infected peripheral blood mononuclear cells
-
Dimitrov DH, Melnick JL, Hollinger FB. Microculture assay for isolation of human immunodeficiency virus type 1 and for titration of infected peripheral blood mononuclear cells. J Clin Microbiol 1990; 28:734-737.
-
(1990)
J Clin Microbiol
, vol.28
, pp. 734-737
-
-
Dimitrov, D.H.1
Melnick, J.L.2
Hollinger, F.B.3
-
31
-
-
0022967777
-
CD8 lymphocytes can control HIV infection in vitro by suppressing virus replication
-
Walker CM, Moody DJ, Stites DP, Levy JA. CD8 lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986; 234:1563-1566.
-
(1986)
Science
, vol.234
, pp. 1563-1566
-
-
Walker, C.M.1
Moody, D.J.2
Stites, D.P.3
Levy, J.A.4
-
32
-
-
0035793065
-
Suppression of HIV replication in the resting CD4 T cell reservoir by autologous CD8 T cells: Implications for the development of therapeutic strategies
-
Chun TW, Justement JS, Moir S, et al. Suppression of HIV replication in the resting CD4 T cell reservoir by autologous CD8 T cells: Implications for the development of therapeutic strategies. Proc Natl Acad Sci USA 2001; 98:253-258.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 253-258
-
-
Chun, T.W.1
Justement, J.S.2
Moir, S.3
-
33
-
-
0030952479
-
Decay characteristics of HIV-1-infected compartments during combination therapy
-
Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997; 387:188-191.
-
(1997)
Nature
, vol.387
, pp. 188-191
-
-
Perelson, A.S.1
Essunger, P.2
Cao, Y.3
-
34
-
-
0032953920
-
Latent infection of CD4 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
-
Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999; 5:512-517.
-
(1999)
Nat Med
, vol.5
, pp. 512-517
-
-
Finzi, D.1
Blankson, J.2
Siliciano, J.D.3
-
35
-
-
0038579210
-
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4 T cells
-
Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4 T cells. Nat Med 2003; 9:727-728.
-
(2003)
Nat Med
, vol.9
, pp. 727-728
-
-
Siliciano, J.D.1
Kajdas, J.2
Finzi, D.3
-
36
-
-
0033609373
-
Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
-
Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999; 340:1605-1613.
-
(1999)
N Engl J Med
, vol.340
, pp. 1605-1613
-
-
Zhang, L.1
Ramratnam, B.2
Tenner-Racz, K.3
-
37
-
-
34249883292
-
Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus
-
Chun TW, Justement JS, Moir S, et al. Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus. J Infect Dis 2007; 195:1762-1764.
-
(2007)
J Infect Dis
, vol.195
, pp. 1762-1764
-
-
Chun, T.W.1
Justement, J.S.2
Moir, S.3
-
38
-
-
79954437524
-
Histone deacetylase inhibitors and HIV latency
-
Margolis DM. Histone deacetylase inhibitors and HIV latency. Curr Opin HIV AIDS 2011; 6:25-29.
-
(2011)
Curr Opin HIV AIDS
, vol.6
, pp. 25-29
-
-
Margolis, D.M.1
-
39
-
-
23744500093
-
Depletion of latent HIV-1 infection in vivo: A proof-of-concept study
-
Lehrman G, Hogue IB, Palmer S, et al. Depletion of latent HIV-1 infection in vivo: A proof-of-concept study. Lancet 2005; 366:549-555.
-
(2005)
Lancet
, vol.366
, pp. 549-555
-
-
Lehrman, G.1
Hogue, I.B.2
Palmer, S.3
-
40
-
-
33847642822
-
Stability of the latent reservoir for HIV-1 in patients receiving valproic acid
-
Siliciano JD, Lai J, Callender M, et al. Stability of the latent reservoir for HIV-1 in patients receiving valproic acid. J Infect Dis 2007; 195:833-836.
-
(2007)
J Infect Dis
, vol.195
, pp. 833-836
-
-
Siliciano, J.D.1
Lai, J.2
Callender, M.3
-
41
-
-
50949096673
-
Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir
-
Sagot-Lerolle N, Lamine A, Chaix ML, et al. Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir. AIDS 2008; 22:1125-1129.
-
(2008)
AIDS
, vol.22
, pp. 1125-1129
-
-
Sagot-Lerolle, N.1
Lamine, A.2
Chaix, M.L.3
-
42
-
-
50949131800
-
Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4T cells
-
Archin NM, Eron JJ, Palmer S, et al. Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4T cells. AIDS 2008; 22:1131-1135.
-
(2008)
AIDS
, vol.22
, pp. 1131-1135
-
-
Archin, N.M.1
Eron, J.J.2
Palmer, S.3
-
43
-
-
84859424538
-
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study
-
Routy JP, Tremblay CL, Angel JB, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study. HIV Med 2012; 13:291-296.
-
(2012)
HIV Med
, vol.13
, pp. 291-296
-
-
Routy, J.P.1
Tremblay, C.L.2
Angel, J.B.3
-
44
-
-
84864203255
-
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
-
Archin NM, Liberty AL, Kashuba AD, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 2012; 487:482-485.
-
(2012)
Nature
, vol.487
, pp. 482-485
-
-
Archin, N.M.1
Liberty, A.L.2
Kashuba, A.D.3
-
45
-
-
60549090253
-
Long-term control of HIV by CCR5Delta32/Delta32 stem-cell transplantation
-
Hutter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5Delta32/Delta32 stem-cell transplantation. N Engl J Med 2009; 360:692-698.
-
(2009)
N Engl J Med
, vol.360
, pp. 692-698
-
-
Hutter, G.1
Nowak, D.2
Mossner, M.3
-
47
-
-
78549235738
-
Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: Implications for eradication
-
Chun TW, Justement JS, Murray D, et al. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: Implications for eradication. AIDS 2010; 24:2803-2808.
-
(2010)
AIDS
, vol.24
, pp. 2803-2808
-
-
Chun, T.W.1
Justement, J.S.2
Murray, D.3
-
48
-
-
10744228049
-
New real-time reverse transcriptaseinitiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma
-
Palmer S, Wiegand AP, Maldarelli F, et al. New real-time reverse transcriptaseinitiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol 2003; 41:4531-4536.
-
(2003)
J Clin Microbiol
, vol.41
, pp. 4531-4536
-
-
Palmer, S.1
Wiegand, A.P.2
Maldarelli, F.3
-
49
-
-
34247584237
-
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia
-
Maldarelli F, Palmer S, King MS, et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathogens 2007; 3:e46.
-
(2007)
PLoS Pathogens
, vol.3
-
-
Maldarelli, F.1
Palmer, S.2
King, M.S.3
-
50
-
-
41649083599
-
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
-
Palmer S, Maldarelli F, Wiegand A, et al. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 2008; 105:3879-3884.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3879-3884
-
-
Palmer, S.1
Maldarelli, F.2
Wiegand, A.3
-
51
-
-
27644524761
-
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
-
Chun TW, Nickle DC, Justement JS, et al. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J Clin Invest 2005; 115:3250-3255.
-
(2005)
J Clin Invest
, vol.115
, pp. 3250-3255
-
-
Chun, T.W.1
Nickle, D.C.2
Justement, J.S.3
-
52
-
-
79957966626
-
Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy
-
Chun TW, Murray D, Justement JS, et al. Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis 2011; 204:135-138.
-
(2011)
J Infect Dis
, vol.204
, pp. 135-138
-
-
Chun, T.W.1
Murray, D.2
Justement, J.S.3
|