Modulation of microtubule dynamics by a TIR domain protein from the intracellular pathogen Brucella melitensis

Biochemical Journal

Volumn 439, Issue 1, 2011, Pages 79-83

  Radhakrishnan, Girish K ^a   Harms, Jerome S ^a   Splitter, Gary A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

BB loop; Brucella; Microtubule; Toll like receptor (TLR); Toll interleukin 1 receptor domain (TIR domain); Toll interleukin 1 receptor domain containing adaptor protein (TIRAP)

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; NOCODAZOLE; PACLITAXEL; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR DOMAIN PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRUCELLA MELITENSIS; CONTROLLED STUDY; CYTOKINE RELEASE; MEMBRANE STABILIZATION; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

BACTERIAL PROTEINS; BRUCELLA MELITENSIS; MICROTUBULES; NOCODAZOLE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-1; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS); BRUCELLA; BRUCELLA MELITENSIS; EUKARYOTA;

EID: 80052767894     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110577     Document Type: Article

References (29)

1. Pasare, C. and Medzhitov, R. (2005) Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560, 11-18
2. Akira, S. (2006) TLR signaling. Curr. Top. Microbiol. Immunol. 311, 1-16
3. Kawai, T. and Akira, S. (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384
4. Miggin, S. M. and O'Neill, L. A. (2006) New insights into the regulation of TLR signaling. J. Leukocyte Biol. 80, 220-226
5. Takeda, K., Kaisho, T. and Akira, S. (2003) Toll-like receptors. Annu. Rev. Immunol. 21, 335-376
6. O'Neill, L. A. and Bowie, A. G. (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7, 353-364
7. Jenkins, K. A. and Mansell, A. (2010) TIR-containing adaptors in Toll-like receptor signalling. Cytokine 49, 237-244
8. Kenny, E. F. and O'Neill, L. A. (2008) Signalling adaptors used by Toll-like receptors: an update. Cytokine 43, 342-349
9. Newman, R. M., Salunkhe, P., Godzik, A. and Reed, J. C. (2006) Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect. Immun. 74, 594-601
10. Salcedo, S. P., Marchesini, M. I., Lelouard, H., Fugier, E., Jolly, G., Balor, S., Muller, A., Lapaque, N., Demaria, O., Alexopoulou, L. et al. (2008) Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathog. 4, e21
11. Cirl, C., Wieser, A., Yadav, M., Duerr, S., Schubert, S., Fischer, H., Stappert, D., Wantia, N., Rodriguez, N., Wagner, H. et al. (2008) Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nat. Med. 14, 399-406
12. Radhakrishnan, G. K., Yu, Q., Harms, J. S. and Splitter, G. A. (2009) Brucella TIR domain-containing protein mimics properties of the Toll-like receptor adaptor protein TIRAP. J. Biol. Chem. 284, 9892-9898
13. Sengupta, D., Koblansky, A., Gaines, J., Brown, T., West, A. P., Zhang, D., Nishikawa, T., Park, S. G., Roop, 2nd, R. M. and Ghosh, S. (2010) Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. J. Immunol. 184, 956-964
14. Xiao, T. S. (2010) Subversion of innate immune signaling through molecular mimicry. J. Clin. Immunol. 30, 638-642
15. Radhakrishnan, G. K. and Splitter, G. A. (2010) Biochemical and functional analysis of TIR domain containing protein from Brucella melitensis. Biochem. Biophys. Res. Commun. 397, 59-63
16. Gundersen, G. G. and Cook, T. A. (1999) Microtubules and signal transduction. Curr. Opin. Cell Biol. 11, 81-94
17. Shelanski, M. L., Gaskin, F. and Cantor, C. R. (1973) Microtubule assembly in the absence of added nucleotides. Proc. Natl. Acad. Sci. U.S.A. 70, 765-768
18. Lee, J. C. and Timasheff, S. N. (1977) In vitro reconstitution of calf brain microtubules: effects of solution variables. Biochemistry 16, 1754-1764
19. Schiff, P. B., Fant, J. and Horwitz, S. B. (1979) Promotion of microtubule assembly in vitro by taxol. Nature 277, 665-667
20. Xiao, H., Verdier-Pinard, P., Fernandez-Fuentes, N., Burd, B., Angeletti, R., Fiser, A., Horwitz, S. B. and Orr, G. A. (2006) Insights into the mechanism of microtubule stabilization by Taxol. Proc. Natl. Acad. Sci. U.S.A. 103, 10166-10173
21. Toshchakov, V. U., Basu, S., Fenton, M. J. and Vogel, S. N. (2005) Differential involvement of BB loops of Toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J. Immunol. 175, 494-500
22. Etienne-Manneville, S. (2010) From signaling pathways to microtubule dynamics: the key players. Curr. Opin. Cell Biol. 22, 104-111
23. Rosette, C. and Karin, M. (1995) Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-κB. J. Cell Biol. 128, 1111-1119
24. Nagata, K., Puls, A., Futter, C., Aspenstrom, P., Schaefer, E., Nakata, T., Hirokawa, N. and Hall, A. (1998) The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 17, 149-158 (Pubitemid 28041056)
25. Best, A., Ahmed, S., Kozma, R. and Lim, L. (1996) The Ras-related GTPase Rac1 binds tubulin. J. Biol. Chem. 271, 3756-3762
26. Murti, K. G., Smith, H. T. and Fried, V. A. (1988) Ubiquitin is a component of the microtubule network. Proc. Natl. Acad. Sci. U.S.A. 85, 3019-3023
27. Bheda, A., Gullapalli, A., Caplow, M., Pagano, J. S. and Shackelford, J. (2010) Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosis. Cell Cycle 9, 980-994
28. Feng, J. (2006) Microtubule: a common target for parkin and Parkinson's disease toxins. Neuroscientist 12, 469-476
29. Fried, V. A. and Smith, H. T. (1989) Ubiquitin: a multifunctional regulatory protein associated with the cytoskeleton. Prog. Clin. Biol. Res. 317, 733-744