Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes

Food and Chemical Toxicology

Volumn 55, Issue , 2013, Pages 172-181

  Fan, Yuan Jing ^a   Rong, Yu ^a   Li, Peng Fei ^a   Dong, Wan Ling ^a   Zhang, Dong Yin ^a   Zhang, Ling ^a   Cui, Min Jie ^a  

^a HEFEI UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Antioxidant enzymes; APAP glucuronide; Genistein; Hepatic detoxification; UGTs

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2E1; GENISTEIN; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 2B1; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; MESSENGER RNA; PARACETAMOL; PARACETAMOL GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; GENE; GENE EXPRESSION; GLUCURONIDATION; GLUCURONOSYLTRANSFERASE 1A1 GENE; GLUCURONOSYLTRANSFERASE 1A10 GENE; GLUCURONOSYLTRANSFERASE 1A6 GENE; GLUCURONOSYLTRANSFERASE 2B1 GENE; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SOYBEAN; TOXIC HEPATITIS;

ACETAMINOPHEN; ANIMALS; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENISTEIN; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; LIVER; MALE; MICE;

EID: 84873257169     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.01.003     Document Type: Article

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