KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure

Clinical Immunology

Volumn 146, Issue 3, 2013, Pages 207-216

  Chen, Tao ^a   Zhu, Lin ^a   Zhou, Yaoyong ^a   Pi, Bin ^a   Liu, Xiaojuan ^a   Deng, Guohong ^b   Zhang, Rong ^b   Wang, Yuming ^b   Wu, Zeguang ^a   Han, Meifang ^a   Luo, Xiaoping ^a   Ning, Qin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acute on chronic liver failure; HBV; KCTD9; Natural killer cell; Virus induced liver injury

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CD69 ANTIGEN; GAMMA INTERFERON; NATURAL KILLER CELL RECEPTOR NKG2A; POTASSIUM CHANNEL; POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING 9; PROTHROMBIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIRUS DNA;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION PROFILING; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; CELL LINE; CHILD; END STAGE LIVER DISEASE; FEMALE; GENE EXPRESSION PROFILING; HEP G2 CELLS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LIVER FAILURE, ACUTE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POTASSIUM CHANNELS; YOUNG ADULT;

EID: 84873180258     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2012.12.013     Document Type: Article

References (48)

1. Liang T.J. Hepatitis B: the virus and disease. Hepatology 2009, 49:S13-S21.
2. Wu Z., Han M., Chen T., Yan W., Ning Q. Acute liver failure: mechanisms of immune-mediated liver injury. Liver Int. 2010, 30:782-794.
3. Roth E., Pircher H. IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells. J. Immunol. 2004, 172:1588-1594.
4. Maini M.K., Boni C., Lee C.K., Larrubia J.R., Reignat S., Ogg G.S., King A.S., Herberg J., Gilson R., Alisa A., Williams R., Vergani D., Naoumov N.V., Ferrari C., Bertoletti A. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. 2000, 191:1269-1280.
5. Liu Z.X., Govindarajan S., Okamoto S., Dennert G. NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection. J. Immunol. 2000, 164:6480-6486.
6. Ochi M., Ohdan H., Mitsuta H., Onoe T., Tokita D., Hara H., Ishiyama K., Zhou W., Tanaka Y., Asahara T. Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. Hepatology 2004, 39:1321-1331.
7. Chen Y., Wei H., Sun R., Dong Z., Zhang J., Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology 2007, 46:706-715.
8. Zou Y., Chen T., Han M., Wang H., Yan W., Song G., Wu Z., Wang X., Zhu C., Luo X., Ning Q. Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J. Immunol. 2010, 184:466-475.
9. Shiv Kumar Sarin A.K., Almeida John A., Kumar Chawla Yogesh, Tat Fan Sheung, Garg Hitendra, Janaka de Silva H., Sadiq Hamid Saeed, Jalan Rajiv, Komolmit Piyawat, George Q.L., Lau K., Madan Kaushal, Mohamed Rosmawati, Ning Qin, Rahman Salimur, Rastogi Archana, Riordan Stephen M., Sakhuja Puja, Samuel Didier, Shah Samir, Chander Sharma Barjesh, Sharma Praveen, Takikawa Yasuhiro, Ram Thapa Babu, Wai Chun-Tao, Yuen Man-Fung Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol. Int. 2009, 3:269-282.
10. Yang I.V., Chen E., Hasseman J.P., Liang W., Frank B.C., Wang S., Sharov V., Saeed A.I., White J., Li J., Lee N.H., Yeatman T.J., Quackenbush J. Within the fold: assessing differential expression measures and reproducibility in microarray assays. Genome Biol. 2002, 3. (research0062).
11. Liu M., Hao Y., Ding H., Yang D., Lu M. Interleukin-10 is expressed in HepG2.2.15 cells and regulated by STAT1 pathway. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2011, 31:625-631.
12. Ganem D., Prince A.M. Hepatitis B virus infection-natural history and clinical consequences. N. Engl. J. Med. 2004, 350:1118-1129.
13. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J. Viral Hepat. 2004, 11:97-107.
14. Wright T.L. Introduction to chronic hepatitis B infection. Am. J. Gastroenterol. 2006, 101(Suppl. 1):S1-S6.
15. Kao J.H., Chen D.S. Global control of hepatitis B virus infection. Lancet Infect. Dis. 2002, 2:395-403.
16. Chan H.L., Jia J. Chronic hepatitis B in Asia-new insights from the past decade. J. Gastroenterol. Hepatol. 2011, 26(Suppl. 1):131-137.
17. Manno C.S., Pierce G.F., Arruda V.R., Glader B., Ragni M., Rasko J.J., Ozelo M.C., Hoots K., Blatt P., Konkle B., Dake M., Kaye R., Razavi M., Zajko A., Zehnder J., Rustagi P.K., Nakai H., Chew A., Leonard D., Wright J.F., Lessard R.R., Sommer J.M., Tigges M., Sabatino D., Luk A., Jiang H., Mingozzi F., Couto L., Ertl H.C., High K.A., Kay M.A. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 2006, 12:342-347.
18. Seki S., Habu Y., Kawamura T., Takeda K., Dobashi H., Ohkawa T., Hiraide H. The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol. Rev. 2000, 174:35-46.
19. Clayton G.M., Silverman W.R., Heginbotham L., Morais-Cabral J.H. Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel. Cell 2004, 119:615-627.
20. Heginbotham L., Kolmakova-Partensky L., Miller C. Functional reconstitution of a prokaryotic K+ channel. J. Gen. Physiol. 1998, 111:741-749.
21. Ghanshani S., Wulff H., Miller M.J., Rohm H., Neben A., Gutman G.A., Cahalan M.D., Chandy K.G. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J. Biol. Chem. 2000, 275:37137-37149.
22. Cantrell D. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 1996, 14:259-274.
23. Ikemoto T., Park M.K. Comparative analysis of the pituitary and ovarian GnRH systems in the leopard gecko: signaling crosstalk between multiple receptor subtypes in ovarian follicles. J. Mol. Endocrinol. 2007, 38:289-304.
24. Naylor T.L., Greshock J., Wang Y., Colligon T., Yu Q.C., Clemmer V., Zaks T.Z., Weber B.L. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res. 2005, 7:R1186-R1198.
25. Baron C.A., Tepper C.G., Liu S.Y., Davis R.R., Wang N.J., Schanen N.C., Gregg J.P. Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Hum. Mol. Genet. 2006, 15:853-869.
26. Paris P.L., Hofer M.D., Albo G., Kuefer R., Gschwend J.E., Hautmann R.E., Fridyland J., Simko J., Carroll P.R., Rubin M.A., Collins C. Genomic profiling of hormone-naive lymph node metastases in patients with prostate cancer. Neoplasia 2006, 8:1083-1089.
27. Campbell K.S., Colonna M. Human natural killer cell receptors and signal transduction. Int. Rev. Immunol. 2001, 20:333-370.
28. Arase H., Mocarski E.S., Campbell A.E., Hill A.B., Lanier L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 2002, 296:1323-1326.
29. Sun J.C., Lanier L.L. The natural selection of herpesviruses and virus-specific NK cell receptors. Viruses 2009, 1:362.
30. Braud V.M., Allan D.S., O'Callaghan C.A., Soderstrom K., D'Andrea A., Ogg G.S., Lazetic S., Young N.T., Bell J.I., Phillips J.H., Lanier L.L., McMichael A.J. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 1998, 391:795-799.
31. Lanier L.L. NK cell receptors. Annu. Rev. Immunol. 1998, 16:359-393.
32. Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J. Exp. Med. 1996, 184:505-518.
33. Merck E., Lees R.K., Voyle R.B., Held W., MacDonald H.R. Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint. J. Immunol. 2011, 187:110-117.
34. Eagle R.A., Traherne J.A., Hair J.R., Jafferji I., Trowsdale J. ULBP6/RAET1L is an additional human NKG2D ligand. Eur. J. Immunol. 2009, 39:3207-3216.
35. Achdout H., Manaster I., Mandelboim O. Influenza virus infection augments NK cell inhibition through reorganization of major histocompatibility complex class I proteins. J. Virol. 2008, 82:8030-8037.
36. Esin S., Batoni G., Counoupas C., Stringaro A., Brancatisano F.L., Colone M., Maisetta G., Florio W., Arancia G., Campa M. Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria. Infect. Immun. 2008, 76:1719-1727.
37. Mandelboim O., Lieberman N., Lev M., Paul L., Arnon T.I., Bushkin Y., Davis D.M., Strominger J.L., Yewdell J.W., Porgador A. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 2001, 409:1055-1060.
38. Orr M.T., Sun J.C., Hesslein D.G., Arase H., Phillips J.H., Takai T., Lanier L.L. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J. Exp. Med. 2009, 206:807-817.
39. Beziat V., Dalgard O., Asselah T., Halfon P., Bedossa P., Boudifa A., Hervier B., Theodorou I., Martinot M., Debre P., Bjorkstrom N.K., Malmberg K.J., Marcellin P., Vieillard V. CMV drives clonal expansion of highly differentiated NKG2C(+) NK cells expressing self-specific KIRs in patients with chronic hepatitis virus infection. Eur. J. Immunol. 2011.
40. Lanier L.L., Corliss B.C., Wu J., Leong C., Phillips J.H. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 1998, 391:703-707.
41. Moretta A., Bottino C., Vitale M., Pende D., Cantoni C., Mingari M.C., Biassoni R., Moretta L. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 2001, 19:197-223.
42. Young N.T., Uhrberg M. KIR expression shapes cytotoxic repertoires: a developmental program of survival. Trends Immunol. 2002, 23:71-75.
43. Tokuyama M., Lorin C., Delebecque F., Jung H., Raulet D.H., Coscoy L. Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation. PloS Pathog. 2011, 7:e1002265.
44. Krebs P., Crozat K., Popkin D., Oldstone M.B., Beutler B. Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood 2011, 117:6582-6588.
45. Bryceson Y.T., Chiang S.C., Darmanin S., Fauriat C., Schlums H., Theorell J., Wood S.M. Molecular mechanisms of natural killer cell activation. J. Innate Immun. 2011, 3:216-226.
46. Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999, 285:727-729.
47. Tangye S.G., Lazetic S., Woollatt E., Sutherland G.R., Lanier L.L., Phillips J.H. Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J. Immunol. 1999, 162:6981-6985.
48. Lindholm C.K. IL-2 receptor signaling through the Shb adapter protein in T and NK cells. Biochem. Biophys. Res. Commun. 2002, 296:929-936.