The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle

Journal of Molecular and Cellular Cardiology

Volumn 56, Issue 1, 2013, Pages 129-138

  Hussain, R I ^a,b,c   Aronsen, J M ^b,c,d   Afzal, F ^a,b,c   Sjaastad, I ^b,c,d   Osnes, J B ^a,b,c   Skomedal, T ^a,b,c   Levy, F O ^a,b,c   Krobert, K A ^a,b,c  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d BJØRKNES UNIVERSITY COLLEGE   (Norway)

Author keywords

Adrenergic receptors; Adenylyl cyclase; Contractility; Heart failure; Muscarinic receptors; Pertussis toxin

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CARBACHOL; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; PERTUSSIS TOXIN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; HEART INFARCTION; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE FAILURE; INOTROPISM; MALE; METABOLIC INHIBITION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CARBACHOL; CARDIOTONIC AGENTS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART FAILURE; HEART VENTRICLES; ISOPROTERENOL; MALE; MUSCARINIC AGONISTS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; PERTUSSIS TOXIN; PHOSPHODIESTERASE 3 INHIBITORS; PHOSPHODIESTERASE 4 INHIBITORS; QUINOLONES; RATS; RATS, WISTAR; ROLIPRAM; VENTRICULAR PRESSURE;

RATTUS;

EID: 84873173169     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.11.015     Document Type: Article

References (65)

1. El-Armouche A., Zolk O., Rau T., Eschenhagen T. Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure. Cardiovasc Res 2003, 60:478-487.
2. Hasenfuss G., Pieske B. Calcium cycling in congestive heart failure. J Mol Cell Cardiol 2002, 34:951-969.
3. Houser S.R., Margulies K.B. Is depressed myocyte contractility centrally involved in heart failure?. Circ Res 2003, 92:350-358.
4. Bartel S., Stein B., Eschenhagen T., Mende U., Neumann J., Schmitz W., et al. Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts. Mol Cell Biochem 1996, 157:171-179.
5. von der L.H., Mende U., Meyer W., Neumann J., Nose M., Schmitz W., et al. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations. Naunyn Schmiedebergs Arch Pharmacol 1991, 344.
6. 1-receptor down-regulation in heart failure. Circ Res 1986, 59:297-309.
7. 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol 1989, 35:295-303.
8. Feldman M.D., Copelas L., Gwathmey J.K., Phillips P., Warren S.E., Schoen F.J., et al. Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation 1987, 75:331-339.
9. Penela P., Murga C., Ribas C., Tutor A.S., Peregrin S., Mayor F. Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res 2006, 69:46-56.
10. 1-adrenergic receptors in the failing human heart. Circulation 1993, 87:454-463.
11. Ruehr M.L., Russell M.A., Bond M. A-kinase anchoring protein targeting of protein kinase A in the heart. J Mol Cell Cardiol 2004, 37:653-665.
12. i alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. J Mol Cell Cardiol 1994, 26:133-149.
13. Eschenhagen T. G proteins and the heart. Cell Biol Int 1993, 17:723-749.
14. o-proteins in failing human myocardium. J Mol Cell Cardiol 2003, 35:1241-1249.
15. Kompa A.R., Gu X.H., Evans B.A., Summers R.J. Desensitization of cardiac β-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins. J Mol Cell Cardiol 1999, 31:1185-1201.
16. i2 suppresses β-adrenergic signaling in cardiac myocytes. FASEB J 2003, 17:523-525.
17. i alpha in human hearts with dilated but not ischemic cardiomyopathy. Circulation 1990, 82:1249-1265.
18. i-proteins in heart failure. Lancet 1988, 2:936-937.
19. i alpha-2 in human end-stage heart failure. Circ Res 1992, 70:688-696.
20. i2 expression, resulting in enhanced coupling to G protein-coupled receptors. J Biol Chem 2002, 277:31,257-31,262.
21. Bristow M.R., Anderson F.L., Port J.D., Skerl L., Hershberger R.E., Larrabee P., et al. Differences in β-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy. Circulation 1991, 84:1024-1039.
22. Feldman A.M., Cates A.E., Veazey W.B., Hershberger R.E., Bristow M.R., Baughman K.L., et al. Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J Clin Invest 1988, 82:189-197.
23. i2 depresses the β-adrenergic response in intact myocardium. Cardiovasc Res 2002, 55:300-308.
24. Koch W.J., Rockman H.A., Samama P., Hamilton R.A., Bond R.A., Milano C.A., et al. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a β ARK inhibitor. Science 1995, 268:1350-1353.
25. Bohm M., Gierschik P., Knorr A., Larisch K., Weismann K., Erdmann E. Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats. J Hypertens 1992, 10:1115-1128.
26. Eschenhagen T., Mende U., Diederich M., Hertle B., Memmesheimer C., Pohl A., et al. Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia. Circulation 1996, 93:763-771.
27. αi2 predisposes to ventricular cardiac arrhythmia. Circ Arrhythm Electrophysiol 2010, 3:391-400.
28. iα2. J Biol Chem 1990, 265:14,784-14,790.
29. i2 subunit gene transcription in polarized LLC-PK1 cells by induction of a CCAAT box nuclear binding factor. J Biol Chem 1993, 268:24,669-24,676.
30. Brown L.A., Harding S.E. The effect of pertussis toxin on β-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure. Br J Pharmacol 1992, 106:115-122.
31. Felder C.C. Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J 1995, 9:619-625.
32. 4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists. FEBS Lett 1995, 377:275-279.
33. Ricny J., Gualtieri F., Tucek S. Constitutive inhibitory action of muscarinic receptors on adenylyl cyclase in cardiac membranes and its stereospecific suppression by hyoscyamine. Physiol Res 2002, 51:131-137.
34. Hilf G., Gierschik P., Jakobs K.H. Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur J Biochem 1989, 186:725-731.
35. i-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. Br J Pharmacol 2011, 162:908-916.
36. Sjaastad I., Sejersted O.M., Ilebekk A., Bjornerheim R. Echocardiographic criteria for detection of postinfarction congestive heart failure in rats. J Appl Physiol 2000, 89:1445-1454.
37. Skomedal T., Osnes J.B., Oye I. Differences between α-adrenergic and β-adrenergic inotropic effects in rat heart papillary muscles. Acta Pharmacol Toxicol (Copenh) 1982, 50:1-12.
38. 1-adrenoceptor-mediated and β-adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle. J Pharmacol Exp Ther 1997, 280:721-729.
39. 1- vs. β-adrenoceptor-mediated inotropic response in rats with congestive heart failure. Acta Physiol Scand 2003, 177:449-458.
40. 7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch Pharmacol 2001, 363:620-632.
41. 2-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. Br J Pharmacol 2011, 162:54-71.
42. i-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril. J Cell Mol Med 2003, 7:277-286.
43. Ping P., Hammond H.K. Diverse G protein and β-adrenergic receptor mRNA expression in normal and failing porcine hearts. Am J Physiol 1994, 267:H2079-H2085.
44. Nagata K., Communal C., Lim C.C., Jain M., Suter T.M., Eberli F.R., et al. Altered β-adrenergic signal transduction in nonfailing hypertrophied myocytes from Dahl salt-sensitive rats. Am J Physiol Heart Circ Physiol 2000, 279:H2502-H2508.
45. Newton G.E., Parker A.B., Landzberg J.S., Colucci W.S., Parker J.D. Muscarinic receptor modulation of basal and β-adrenergic stimulated function of the failing human left ventricle. J Clin Invest 1996, 98:2756-2763.
46. Vatner D.E., Sato N., Galper J.B., Vatner S.F. Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure. Circulation 1996, 94:102-107.
47. i protein mediated muscarinic receptor adenylyl cyclase in chronic ischaemic heart failure in the rat. Cardiovasc Res 1993, 27:2065-2070.
48. Watkins D.C., Northup J.K., Malbon C.C. Pertussis toxin treatment in vivo is associated with a decline in G-protein β-subunits. J Biol Chem 1989, 264:4186-4194.
49. iα proteins increases arrhythmogenic effects of β-adrenergic stimulation in the heart. J Mol Cell Cardiol 1998, 30:1917-1928.
50. Xiao R.P., Ji X., Lakatta E.G. Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol 1995, 47:322-329.
51. 2+ channels in canine heart failure. Circ Res 2005, 97:566-573.
52. Tilley D.G., Rockman H.A. Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment. Expert Rev Cardiovasc Ther 2006, 4:417-432.
53. Yoshida H., Tanonaka K., Miyamoto Y., Abe T., Takahashi M., Anand-Srivastava M.B., et al. Characterization of cardiac myocyte and tissue β-adrenergic signal transduction in rats with heart failure. Cardiovasc Res 2001, 50:34-45.
54. Mongillo M., McSorley T., Evellin S., Sood A., Lissandron V., Terrin A., et al. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res 2004, 95:67-75.
55. Kaasik A., Ohisalo J.J. Membrane-bound phosphodiesterases in rat myocardium. J Pharm Pharmacol 1996, 48:962-964.
56. Burns D.L. Subunit structure and enzymic activity of pertussis toxin. Microbiol Sci 1988, 5:285-287.
57. Katada T., Bokoch G.M., Northup J.K., Ui M., Gilman A.G. The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem 1984, 259:3568-3577.
58. i regulation of human type V and VI adenylyl cyclase. J Biol Chem 2005, 280:1808-1816.
59. Wang T., Brown M.J. Differential expression of adenylyl cyclase subtypes in human cardiovascular system. Mol Cell Endocrinol 2004, 223:55-62.
60. Steinberg S.F. The molecular basis for distinct β-adrenergic receptor subtype actions in cardiomyocytes. Circ Res 1999, 85:1101-1111.
61. Gilman A.G. G proteins: transducers of receptor-generated signals. Annu Rev Biochem 1987, 56:615-649.
62. Smigel M.D. Purification of the catalyst of adenylate cyclase. J Biol Chem 1986, 261:1976-1982.
63. Northup J.K., Sternweis P.C., Gilman A.G. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. J Biol Chem 1983, 258:11,361-11,368.
64. Northup J.K., Smigel M.D., Sternweis P.C., Gilman A.G. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton α subunit. J Biol Chem 1983, 258:11,369-11,376.
65. Bokoch G.M. The presence of free G protein βγ subunits in human neutrophils results in suppression of adenylate cyclase activity. J Biol Chem 1987, 262:589-594.