Inactivation of G(iα) proteins increases arrhythmogenic effects of β-adrenergic stimulation in the heart

Journal of Molecular and Cellular Cardiology

Volumn 30, Issue 10, 1998, Pages 1917-1928

  Grimm, Michael ^a   Gsell, Stefanie ^a   Mittmann, Clemens ^a   Nose, Monika ^a   Scholz, Hasso ^a   Weil, Joachim ^a   Eschenhagen, Thomas ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Acetylcholine pharmacology; Adrenergic agonists pharmacology; Arrhythmias; G proteins; Myocardial contraction drug effects

Indexed keywords

CARBACHOL; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; MUSCARINIC RECEPTOR; PERTUSSIS TOXIN; PHOSPHORUS 32; PROTEIN SUBUNIT; ADENOSINE DIPHOSPHATE RIBOSE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BORDETELLA VIRULENCE FACTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; BETA ADRENERGIC STIMULATION; CHRONOTROPISM; CONTROLLED STUDY; DOSE RESPONSE; HEART; HEART ATRIUM; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; HEART RATE; HEART RIGHT ATRIUM; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; HEART CONTRACTION; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALIA;

ADENOSINE DIPHOSPHATE RIBOSE; ADRENERGIC BETA-AGONISTS; ANIMALS; CARBACHOL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART ATRIA; HEART RATE; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PERTUSSIS TOXIN; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; VIRULENCE FACTORS, BORDETELLA;

EID: 0032173440     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1998.0769     Document Type: Article

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