Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G i-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle

British Journal of Pharmacology

Volumn 162, Issue 4, 2011, Pages 908-916

  Hussain, R I ^a,b   Afzal, F ^a,b   Mork H K ^a,b   Aronsen, J M ^a,b   Sjaastad, I ^a,b,c   Osnes, J B ^a,b   Skomedal, T ^a,b   Levy, F O ^a,b   Krobert, K A ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

adrenoceptors; compartmentation; contractility; G i protein; serotonin (5 HT)

Indexed keywords

ADENYLATE CYCLASE; ATROPINE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; MUSCARINIC M2 RECEPTOR; PERTUSSIS TOXIN; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; EVOKED RESPONSE; FEMALE; HEART INFARCTION; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE FAILURE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BLOCKING; REGULATORY MECHANISM;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOTONIC AGENTS; CYCLIC AMP; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART FAILURE; HEART VENTRICLES; MALE; MUSCARINIC ANTAGONISTS; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, MUSCARINIC; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN 5-HT4 RECEPTOR AGONISTS; SEROTONIN ANTAGONISTS;

EID: 79251488182     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01097.x     Document Type: Article

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