Absence of the inhibitory g-protein gαi2 predisposes to ventricular cardiac arrhythmia

Circulation: Arrhythmia and Electrophysiology

Volumn 3, Issue 4, 2010, Pages 391-400

  Zuberi, Zia ^a   Nobles, Muriel ^a   Sebastian, Sonia ^a   Dyson, Alex ^a   Lim, Shiang Y ^a   Breckenridge, Ross ^a   Birnbaumer, Lutz ^b   Tinker, Andrew ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Calcium channel; Gi; Inhibitory G protein; Long QT syndrome; Ventricular tachycardia

Indexed keywords

CALCIUM CHANNEL L TYPE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I1; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I3; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; CALCIUM; GNAI2 PROTEIN, MOUSE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; POTASSIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ELECTROSTIMULATION; GENE DELETION; GENE EXPRESSION PROFILING; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART STIMULATION; HEART VENTRICLE TACHYCARDIA; HEART VENTRICLE WALL; HISTOPATHOLOGY; IN VIVO STUDY; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; QT PROLONGATION; ACTION POTENTIAL; ANIMAL; DISEASE MODEL; DOPPLER ECHOCARDIOGRAPHY; GENETICS; HEART MUSCLE CONDUCTION SYSTEM; HEART PACING; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; TELEMETRY; TIME;

ACTION POTENTIALS; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY, DOPPLER, PULSED; ELECTROCARDIOGRAPHY, AMBULATORY; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; HEART CONDUCTION SYSTEM; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; POTASSIUM; TACHYCARDIA, VENTRICULAR; TELEMETRY; TIME FACTORS;

EID: 77956660831     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.109.894329     Document Type: Article

References (6)

1. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003 April;4(2):249-64.
2. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3:Article3.
3. Janvier NC, McMorn SO, Harrison SM, Taggart P, Boyett MR. The role of Na(+)-Ca2+ exchange current in electrical restitution in ferret ventricular cells. J Physiol 1997 October 15;504 ( Pt 2):301-14.
4. Knollmann BC, Schober T, Petersen AO, Sirenko SG, Franz MR. Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution. Am J Physiol Heart Circ Physiol 2007 January;292(1):H614-H621.
5. Yuan W, Ginsburg KS, Bers DM. Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes. J Physiol 1996 June 15;493 ( Pt 3):733-46.
6. Xu H, Guo W, Nerbonne JM. Four kinetically distinct depolarization- activated K+ currents in adult mouse ventricular myocytes. J Gen Physiol 1999 May;113(5):661-78.