Intracellular β-blockade: Overexpression of Gαi2 depresses the β-adrenergic response in intact myocardium

Cardiovascular Research

Volumn 55, Issue 2, 2002, Pages 300-308

  Janssen, Paul M L ^a,b,d   Schillinger, Wolfgang ^a   Donahue, J Kevin ^b   Zeitz, Oliver ^a   Emami, Shahriyar ^a   Lehnart, Stephan E ^a   Weil, Joachim ^c   Eschenhagen, Thomas ^c   Hasenfuss, Gerd ^a   Prestle, Juergen ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

Adrenergic (ant)agonists; Contractile function; e c coupling; G proteins; Gene expression; Inotropic agents

Indexed keywords

ADENOVIRUS VECTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; PERTUSSIS TOXIN; PROTEIN GALPHAI2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENE TRANSFER; HEART CONTRACTION; INOTROPISM; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; TRANSGENE;

ADENOVIRIDAE; ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOTONIC AGENTS; CELL CULTURE TECHNIQUES; CELL SIZE; GENETIC VECTORS; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; ISOPROTERENOL; MYOCARDIAL CONTRACTION; MYOCARDIUM; PERTUSSIS TOXIN; PROTO-ONCOGENE PROTEINS; RABBITS; TRANSFECTION; TRANSGENES; UP-REGULATION; VIRULENCE FACTORS, BORDETELLA;

EID: 0036069609     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00406-6     Document Type: Article

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