Constitutive inhibitory action of muscarinic receptors on adenylyl cyclase in cardiac membranes and its stereospecific suppression by hyoscyamine

Physiological Research

Volumn 51, Issue 2, 2002, Pages 131-137

  Říčný, Jan ^a   Gualtieri, F ^b   Tucek S ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Adenylyl cyclase; Atropine; Constitutive activity of receptors; Heart; Hyoscyamine; Inverse agonist action; Muscarinic receptors

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ADENYLATE CYCLASE; ALAMETHICIN; ATROPINE; CARBACHOL; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HYOSCYAMINE; ION CHANNEL; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PRESYNAPTIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; HEART ATRIUM MUSCLE; HEART MUSCLE FIBER MEMBRANE; HEART VENTRICLE; MALE; NONHUMAN; RAT; STEREOSPECIFICITY;

EID: 0036246145     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Studies on the stereospecificity of closely related compounds which block postganglionic acetylcholine receptors in the guinea-pig ileum
2. q
3. Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains
4. Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins
5. Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand
6. High-performance liquid chromatographic determination of 3′,5′-cyclic adenosine monophosphate in human platelets
7. Stereoselective increase in cholinergic transmission by R-(+)-hyoscyamine
8. Changes in membrane currents in bullfrog atrium produced by acetylcholine
9. Muscarinic presynaptic autoreceptors and muscarinic postsynaptic receptors have opposital stereochemical requirements
10. + currents in frog and rat cardiac cells
11. Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes
12. 5 subtypes of muscarinic acetylcholine receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists
13. +)-ATPase, beta-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles
14. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
15. Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis
16. Differential regulation of cAMP-mediated gene transcription by m1 and m4 muscarinic acetylcholine receptors
17. A simplification of the protein assay method of Lowry et al. which is more generally applicable
18. Negative antagonists promote an inactive conformation of the beta2-adrenergic receptor
19. Constitutively active G protein-coupled receptors: Potential mechanisms of receptor activation
20. Characterization of adenylyl cyclase in heart sarcolemma in the absence or presence of alamethicin
21. Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells
22. Porcine m2 muscarinic acetylcholine receptor-effector coupling in Chinese hamster ovary cells