Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways

International Journal of Molecular Medicine

Volumn 31, Issue 3, 2013, Pages 597-606

  Chen, Yali ^a   Jiang, Jinyao ^a   Miao, Huibing ^a   Chen, Xingjuan ^a   Sun, Xuejun ^b   Li, Yongjun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hydrogen rich saline solution; Ras ERK1 2 MEK1 2; Vascular smooth muscle cell

Indexed keywords

ANTIOXIDANT; CYCLINE; HYDROGEN; HYDROGEN RICH SALINE SOLUTION; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN KINASE B; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON, CORONARY; ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CORONARY RESTENOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYDROGEN; HYPERPLASIA; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; NEOINTIMA; PROTO-ONCOGENE PROTEINS C-AKT; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SODIUM CHLORIDE; WOUND HEALING;

EID: 84873160345     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1256     Document Type: Article

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