Mycophenolic acid inhibits platelet-derived growth factor-induced reactive oxygen species and mitogen-activated protein kinase activation in rat vascular smooth muscle cells

American Journal of Transplantation

Volumn 4, Issue 12, 2004, Pages 1982-1990

  Park, Jehyun ^a   Ha, Hunjoo ^b   Seo, Jiyeon ^a   Kim, Myoung Soo ^c   Kim, Hae Jin ^a   Huh, Kyu Ha ^a   Park, Kiil ^a   Kim, Yu Seun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c Yonsei University Wonju College of Medicine   (South Korea)

Author keywords

Mitogen activated protein kinases; Mycophenolic acid; Reactive oxygen species; Vascular smooth muscle cells

Indexed keywords

ANTIOXIDANT; GUANOSINE; INOSINATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYCOPHENOLIC ACID; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; THROMBIN; TRANSCRIPTION FACTOR;

ALLOGRAFT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPETITIVE INHIBITION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; KIDNEY TRANSPLANTATION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT; RESTENOSIS; SECOND MESSENGER; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL DIVISION; CELLS, CULTURED; ENZYME ACTIVATION; GUANOSINE; MUSCLE, SMOOTH, VASCULAR; MYCOPHENOLIC ACID; PLATELET-DERIVED GROWTH FACTOR; RATS; REACTIVE OXYGEN SPECIES; THYMIDINE;

EID: 10044232981     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00610.x     Document Type: Article

References (32)

1. Häyry P, Savolainen H, Luoto NM, Petrov L, Loubtchenkov M, Aavik E. Emerging therapeutic strategies for the prevention and treatment of chronic allograft rejection. Transplant Proc 2000; 32: 519.
2. Fellstrom BC, Larsson E. Pathogenesis and treatment perspectives of chronic graft rejection (CVR). Immunol Rev 1993; 134: 83-97.
3. Azuma H, Tilney NL. Chronic graft rejection. Curr Opin Immunol 1994; 6: 770-776.
4. McDonald PC, Wong D, Granville DJ, Mcmanus BM. Emerging role of endothelial cell and smooth muscle cells in transplant vascular disease. Transplant Rev 1999; 13: 109-127.
5. Pietila K, Nikkari T. Role of the arterial smooth muscle cell in the pathogenesis of atherosclerosis. Med Biol 1983; 61: 31-44.
6. Bauters C, Isner JM. The biology of restenosis. Prog Cardiovasc Dis 1997; 40: 107-116.
7. Moon JI, Kim MS, Kim YS et al. Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: In vitro study. Transplant Proc 2000; 32: 2026-2027.
8. Hauser IA, Renders L, Radeke HH, Sterzel RB, Goppelt-Styruebe M. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion. Nephrol Dial Transplant 1999; 14: 58-63.
9. Badid C, Vincent M, Mcgregor B et al. Mycophenolate mofetil reduces myofibroblast infiltration and collagen III deposition in rat remnant kidney. Kidney Int 2000; 58: 51-61.
10. Mele TS, Halloran PF. The use of mycophenolate mofetil in transplant recipients. Immunopharmacology 2000; 47: 215-245.
11. Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000; 47: 85-118.
12. Allison AC, Eugui EM. Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs. Transplant Proc 1993; 25: 8-18.
13. Rhee SG. Redox signaling: Hydrogen peroxide as intracellular messenger. Exp Mol Med 1999; 31: 53-59.
14. Azevedo LC, Pedro MA, Souza LC et al. Oxidative stress as a signaling mechanism of the vascular response to injury: The redox hypothesis of restenosis. Cardiovasc Res 2000; 47: 436-445.
15. Irani K. Oxidant signaling in vascular cell growth, death, and survival. A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res 2000; 87: 179-183.
16. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol 2000; 279: L1005-L1028.
17. Griendling KK, Sorescu D, Lassegue B, Fukai MU. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathology. Arterioscler Thromb Vasc Biol 2000; 20: 2175-2183.
18. 2 for platelet-derived growth factor signal transduction. Science 1995; 270: 296-299.
19. Berk BC. Vascular smooth muscle growth: Autocrine growth mechanisms. Physiol Rev 2001; 81: 999-1030.
20. Nelson PR, Yamamura S, Mureebe L, Itoh H, Kent KC. Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase. J Vasc Surg 1998; 27: 117-125.
21. Kanda Y, Nishio E, Kuroki Y, Mizuno K, Watanabe Y. Thrombin activates p38 mitogen-activated protein kinase in vascular smooth muscle cells. Life Sci 2001; 68: 1989-2000.
22. Ohashi N, Matsumori A, Furukawa Y et al. Role of p38 mitogen-activated protein kinase in neointimal hyperplasia after vascular injury. Arterioscler Thromb Vasc Biol 2000; 20: 2521-2526.
23. Kim YS, Kim MS, Ha H, Park J, Kim HJ, Park K. Effects of carvedilol alone and in the presence of cyclosporine A on the DNA synthesis of cultured vascular smooth muscle cells. Surg Today 2002; 32: 230-235.
24. Jiang B, Yamamura S, Nelson PR, Mureebe L, Kent KC. Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. Surgery 1996; 120: 427-432.
25. Laszlo SE, Visco D, Agarwal L et al. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett 1998; 8: 2689-2694.
26. Mohacsi PJ, Tuller D, Hulliger B, Wijngaard PLJ. Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet-derived growth factor or endothelial cell growth factor. J Heart Lung Transplant 1997; 16: 484-492.
27. Kreuzer J, Viedt C, Brandes RP et al. Platelet-derived growth factor-activates production of reactive oxygen species by NAD(P)H-oxidase in smooth muscle cells through Gi1,2. FASEB J 2003; 17: 38-40.
28. Cuda G, Paterno R, Ceravolo R et al. Protection of human endothelial cells from oxidative stress. Circulation 2002; 105: 968-974.
29. Bar-Sagi D, Hall A. Ras and Rho GTPases: A family reunion. Cell 2000; 103: 227-238.
30. Olah E, Kote Z, Natsumeda Y et al. Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells. Cancer Biochem Biophys 1990; 11: 107-117.
31. Olah E, Natsumeda Y, Ikegami T et al. Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells. Proc Natl Acad Sci USA 1988; 85: 6533-6537.
32. Kharbanda SM, Sherman ML, Kufe DW. Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells. Blood 1990; 75: 583-588.