Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling

Pharmacological Research

Volumn 59, Issue 1, 2009, Pages 48-56

  Wu, Jiunn Ren ^a,b   Liou, Shu Fen ^c   Lin, Shin Wha ^d   Chai, Chee Yin ^d   Dai, Zen Kong ^a   Liang, Jyh Chong ^e   Chen, Ing Jun ^d   Yeh, Jwu Lai ^d  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MUNICIPAL HSIAO KANG HOSPITAL   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e CHIN MIN INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

Lercanidipine; MAP kinase; Platelet derived growth factor; Reactive oxygen species; Vascular smooth muscle cell

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; CALCIUM CHANNEL BLOCKING AGENT; CYCLINE; LERCANIDIPINE; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INJURY; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR EFFECT; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; IN-STENT RESTENOSIS; INTIMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CELL MOVEMENT; CELL PROLIFERATION; DIHYDROPYRIDINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G1 PHASE; MALE; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROLIFERATING CELL NUCLEAR ANTIGEN; RAS PROTEINS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; STAT3 TRANSCRIPTION FACTOR; TUNICA INTIMA;

EID: 58149236965     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2008.09.015     Document Type: Article

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