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Volumn 7, Issue 3, 2013, Pages 1010-1020

Cytokine profile in relapsing-remitting Multiple sclerosis patients and the association between progression and activity of the disease

Author keywords

Cytokines; Disability; Disease activity; Disease progression; Multiple sclerosis

Indexed keywords

CYTOKINE; GADOLINIUM; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

EID: 84873111782     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1256     Document Type: Article
Times cited : (107)

References (76)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M and Martin M: Immunology of multiple sclerosis. Annals Review Immunology 23:683-747, 2005. (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 3
    • 33947681258 scopus 로고    scopus 로고
    • Cytokine changes during interferon-beta therapy in multiple sclerosis: Correlations with interferon dose and MRI response
    • DOI 10.1016/j.jneuroim.2007.01.011, PII S016557280700032X
    • Graber JJ, Ford D, Zhan M, Francis G, Panitch H and Dhib-Jalbut S: Cytokine changes during interferon. beta therapy in multiple sclerosis: correlation with interferon dose and MRI response. J Neuroimmunol 185:168-174, 2007. (Pubitemid 46497443)
    • (2007) Journal of Neuroimmunology , vol.185 , Issue.1-2 , pp. 168-174
    • Graber, J.J.1    Ford, D.2    Zhan, M.3    Francis, G.4    Panitch, H.5    Dhib-Jalbut, S.6
  • 5
    • 4444254434 scopus 로고    scopus 로고
    • Increased expression of capase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis
    • DOI 10.1191/1352458504ms1071oa
    • Huang WX, Huang P and Hillert J: Increased expression of caspase.1 and interleukin. 18 in peripheral blood mononuclear cells in patients with multiple sclerosis. Mult Scler 10:482-487, 2004. (Pubitemid 39207218)
    • (2004) Multiple Sclerosis , vol.10 , Issue.5 , pp. 482-487
    • Huang, W.-X.1    Huang, P.2    Hillert, J.3
  • 6
    • 18044382584 scopus 로고    scopus 로고
    • Cytokines in multiple sclerosis: From bench to bedside
    • DOI 10.1016/j.pharmthera.2004.11.007
    • Imitola J, Chitnis T and Khoury SJ: Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther 106:163-177, 2005. (Pubitemid 40603863)
    • (2005) Pharmacology and Therapeutics , vol.106 , Issue.2 , pp. 163-177
    • Imitola, J.1    Chitnis, T.2    Khoury, S.J.3
  • 7
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin. 1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    • Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC and Mills KH: Interleukin. 1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31:331-341, 2009.
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1    Lalor, S.J.2    Sweeney, C.M.3    Brereton, C.F.4    Lavelle, E.C.5    Mills, K.H.6
  • 9
    • 78649752513 scopus 로고    scopus 로고
    • Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • Domingues HS, Mues M, Lassmann H, Wekerle H and Krishnamoorthy G: Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One 5:e15531, 2010.
    • (2010) PLoS One , vol.5
    • Domingues, H.S.1    Mues, M.2    Lassmann, H.3    Wekerle, H.4    Krishnamoorthy, G.5
  • 10
    • 0026591484 scopus 로고
    • Cytokine secretion by multiple sclerosis monocytes
    • Rudick RA and Rosahoff RM: Cytokine secretion by multiple sclerosis monocytes. Arch Neurol 49:265-270, 1992.
    • (1992) Arch Neurol , vol.49 , pp. 265-270
    • Rudick, R.A.1    Rosahoff, R.M.2
  • 11
    • 0032752119 scopus 로고    scopus 로고
    • Changes in plasma cytokines induced by interferon-β1a treatment in patients with multiple sclerosis
    • DOI 10.1016/S0165-5728(99)00103-4, PII S0165572899001034
    • Duddy ME, Armstrong MA, Crockard AD and Hawkins SA: Changes in plasma cytokines induced by interferon. beta 1a treatment in patients with multiple sclerosis. J Neuroimmunol 101:98-109, 1999. (Pubitemid 29505178)
    • (1999) Journal of Neuroimmunology , vol.101 , Issue.1 , pp. 98-109
    • Duddy, M.E.1    Armstrong, M.A.2    Crockard, A.D.3    Hawkins, S.A.4
  • 12
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF: Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452, 1983. (Pubitemid 14237132)
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 13
    • 0024990661 scopus 로고
    • Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenic and clinical implications
    • Kermode AG, Thompson AJ, Tofts P, Macmanus DG, Kendall BE, Kingsley DP, Moseley IF, Rudge P and McDonald WI: Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Brain 113:1477-1489, 1990. (Pubitemid 20385925)
    • (1990) Brain , vol.113 , Issue.5 , pp. 1477-1489
    • Kermode, A.G.1    Thompson, A.J.2    Tofts, P.3    MacManus, D.G.4    Kendall, B.E.5    Kingsley, D.P.E.6    Moseley, I.F.7    Rudge, P.8    McDonald, W.I.9
  • 14
    • 0001710321 scopus 로고    scopus 로고
    • MRI in multiple sclerosis: Correlation with expanded disability status scale (EDSS)
    • Barkhof F: MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS). Mult Scler 5:283-286, 1999. (Pubitemid 29405626)
    • (1999) Multiple Sclerosis , vol.5 , Issue.4 , pp. 283-286
    • Barkhof, F.1
  • 15
    • 0027934602 scopus 로고
    • Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
    • Rieckmann P, Albrecht M, Kitze B, Weber T, Tumani H, Broocks A, Luer W and Poser S: Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 44:1523-1526, 1994. (Pubitemid 24247453)
    • (1994) Neurology , vol.44 , Issue.8 , pp. 1523-1526
    • Rieckmann, P.1    Albrecht, M.2    Kitze, B.3    Weber, T.4    Tumani, H.5    Broocks, A.6    Luer, W.7    Poser, S.8
  • 16
    • 0029315079 scopus 로고
    • Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Olsson T: Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurology 45(Suppl 6):S11-S15, 1995.
    • (1995) Neurology , vol.45 , Issue.SUPPL. 6
    • Olsson, T.1
  • 17
    • 0032700063 scopus 로고    scopus 로고
    • IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis
    • DOI 10.1016/S0165-5728(99)00139-3, PII S0165572899001393
    • Okuda Y, Sakoda S, Fujimura H, Saeki Y, Kishimoto T and Yanagihara T: IL-6 plays a crucial role in the induction phase of myelin olygodendrocyte glucoprotein 35.55 induced experimental autoimmune encephalocyelitis. J Neuroimmunol 10:188-196, 1999. (Pubitemid 29516459)
    • (1999) Journal of Neuroimmunology , vol.101 , Issue.2 , pp. 188-196
    • Okuda, Y.1    Sakoda, S.2    Fujimura, H.3    Saeki, Y.4    Kishimoto, T.5    Yanagihara, T.6
  • 20
    • 84856661087 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and interleukin-4 in cerbrospinal fluid and plasma in different clinical forms of multiple sclerosis
    • Obradović D, Kataranovski M, Dincić E, Obradović S and Colić M: Tumor necrosis factor-alpha and interleukin-4 in cerbrospinal fluid and plasma in different clinical forms of multiple sclerosis. Vojnosanit Pregl 69:151-156, 2012.
    • (2012) Vojnosanit Pregl , vol.69 , pp. 151-156
    • Obradović, D.1    Kataranovski, M.2    Dincić, E.3    Obradović, S.4    Colić, M.5
  • 23
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD and Reingold SC: Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907-911, 1996.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 24
  • 27
    • 84873129332 scopus 로고    scopus 로고
    • Ministry of Health National Health Surveillance Agency Board ANVISA:, June 14, Official Gazette: 24 Jun, 2004, Brazil In Portuguese
    • Ministry of Health National Health Surveillance Agency Board (ANVISA): Resolution RDC no. 153, June 14, 2004. Official Gazette: 24 Jun, 2004, Brazil (In Portuguese).
    • (2004) Resolution RDC No. 153
  • 29
    • 3142556134 scopus 로고    scopus 로고
    • Development of biomarkers in multiple sclerosis
    • DOI 10.1093/brain/awh176
    • Bielekova B and Martin R: Development of biomarkers in multiple sclerosis. Brain 127:1463-1478, 2004. (Pubitemid 38899400)
    • (2004) Brain , vol.127 , Issue.7 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 30
    • 0031713584 scopus 로고    scopus 로고
    • Are there any body fluid markers of brain atrophy in multiple sclerosis?
    • Giovannoni G, Green AJ and Thompson EJ: Are there any body fluid markers of brain atrophy in multiple sclerosis? Mult Scler 4:138-142, 1998. (Pubitemid 28410040)
    • (1998) Multiple Sclerosis , vol.4 , Issue.3 , pp. 138-142
    • Giovannoni, G.1    Green, A.J.E.2    Thompson, E.J.3
  • 33
    • 78650309500 scopus 로고    scopus 로고
    • The role of non. HLA single nucleotide polymorphisms in multiple sclerosis susceptibility
    • Bahreini SA, Jabalameli MR, Saadatnia M and Zahednasab H: The role of non. HLA single nucleotide polymorphisms in multiple sclerosis susceptibility. J Neuroimmunol 229:5-15, 2010.
    • (2010) J Neuroimmunol , vol.229 , pp. 5-15
    • Bahreini, S.A.1    Jabalameli, M.R.2    Saadatnia, M.3    Zahednasab, H.4
  • 34
    • 84860883725 scopus 로고    scopus 로고
    • Sex-related factors in multiple sclerosis susceptibility and progression
    • Voskuhl RR and Gold SM: Sex-related factors in multiple sclerosis susceptibility and progression. Nat Rev Neurol 8:255-263, 2012.
    • (2012) Nat Rev Neurol , vol.8 , pp. 255-263
    • Voskuhl, R.R.1    Gold, S.M.2
  • 35
    • 0345601517 scopus 로고    scopus 로고
    • PRISMS (Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomized double blind placebo controlled study interferon beta 1a in relapsing/remitting multiples sclerosis
    • Ebers GC: PRISMS (Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomized double blind placebo controlled study interferon beta 1a in relapsing/remitting multiples sclerosis. Lancet 352:1498-1504, 1998.
    • (1998) Lancet , vol.352 , pp. 1498-1504
    • Ebers, G.C.1
  • 36
    • 0037154192 scopus 로고    scopus 로고
    • Disease modifying therapies in multiple sclerosis: Report of the therapeutics and technology assessment subcommittee of the American academy of neurology and the MS council for clinical practice guidelines
    • Goodin DS, Frohman EM, Garmany GP Jr, Halper J, Likosky WH, Lublin FD, Silberberg DH, Stuart WH and van den Noort S: Disease modifying therapies in multiple sclerosis: reports of the therapeutics and technology assessment subcommittee of American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology 22:169-178, 2002. (Pubitemid 34086933)
    • (2002) Neurology , vol.58 , Issue.2 , pp. 169-178
    • Goodin, D.S.1    Frohman, E.M.2    Garmany Jr., G.P.3    Halper, J.4    Likosky, W.H.5    Lublin, F.D.6    Silberberg, D.H.7    Stuart, W.H.8    Van Den Noort, S.9
  • 37
    • 9644310402 scopus 로고    scopus 로고
    • Brain microglia and blood-derived macrophages: Molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease
    • Raivich G and Banati R: Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res Rev 46:161-181, 2004.
    • (2004) Brain Res Rev , vol.46 , pp. 161-181
    • Raivich, G.1    Banati, R.2
  • 41
    • 13244269848 scopus 로고    scopus 로고
    • IL-1-regulated responses in astrocytes: Relevance to injury and recovery
    • DOI 10.1002/glia.20109
    • John GR, Lee SC, Song X, Rivieccio M and Brosnan CF: IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia 49:161-176, 2005. (Pubitemid 40188496)
    • (2005) GLIA , vol.49 , Issue.2 , pp. 161-176
    • John, G.R.1    Lee, S.C.2    Song, X.3    Rivieccio, M.4    Brosnan, C.F.5
  • 42
    • 0033215124 scopus 로고    scopus 로고
    • Inflammatory cytokines IL-1α, IL-1β, IL-6, and TNF-α impart neuroprotection to an excitotoxin through distinct pathways
    • Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW and Gahring LC: Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6 and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol 163:3963-3968, 1999. (Pubitemid 29450925)
    • (1999) Journal of Immunology , vol.163 , Issue.7 , pp. 3963-3968
    • Carlson, N.G.1    Wieggel, W.A.2    Chen, J.3    Bacchi, A.4    Rogers, S.W.5    Gahring, L.C.6
  • 44
    • 0027506423 scopus 로고
    • Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients
    • Imamura K, Suzumura A, Hayashi F and Marunouchi T: Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients. Acta Neurol Scand 87:281-285, 1993. (Pubitemid 23122221)
    • (1993) Acta Neurologica Scandinavica , vol.87 , Issue.4 , pp. 281-285
    • Imamura, K.1    Suzumura, A.2    Hayashi, F.3    Muranouchi, T.4
  • 45
    • 0031852288 scopus 로고    scopus 로고
    • IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • DOI 10.1002/(SICI)1521-4141(199807)28:07<2178::AID-IMMU2178>3.0. CO;2-D
    • Eugster HP, Frei K, Kopf M, Lassmann H and Fontana A: IL-6-deficient-mice resist myelin oligodendrocyte glycoprotein. induced autoimmune encephalomyelitis. Eur J Immunol 28:2178-2187, 1998. (Pubitemid 28321302)
    • (1998) European Journal of Immunology , vol.28 , Issue.7 , pp. 2178-2187
    • Eugster, H.-P.1    Frei, K.2    Kopf, M.3    Lassmann, H.4    Fontana, A.5
  • 46
    • 0025176658 scopus 로고
    • Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF
    • Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC and Dinarello CA: Correlations and interactions in the production of interleukin-6 (IL-6), IL-1 and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75:40-47, 1990. (Pubitemid 20031487)
    • (1990) Blood , vol.75 , Issue.1 , pp. 40-47
    • Schindler, R.1    Mancilla, J.2    Endres, S.3    Ghorbani, R.4    Clark, S.C.5    Dinarello, C.A.6
  • 47
    • 0028031990 scopus 로고
    • Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55
    • Tilg H, Trehu E, Atkins MB, Dinarello CA and Mier JW: Interleukin. 6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 83:113-118, 1994. (Pubitemid 24016522)
    • (1994) Blood , vol.83 , Issue.1 , pp. 113-118
    • Tilg, H.1    Trehu, E.2    Atkins, M.B.3    Dinarello, C.A.4    Mier, J.W.5
  • 49
    • 0001668516 scopus 로고
    • Interleukin-6
    • Thompson ed. Academic Press, London
    • Hirano T: Interleukin-6. In: The Handbook of Cytokines. Thompson (ed.) Academic Press, London, pp145-169, 1994.
    • (1994) The Handbook of Cytokines , pp. 145-169
    • Hirano, T.1
  • 50
    • 85056026779 scopus 로고    scopus 로고
    • Th17 cells in inflammatory conditions
    • Cooke A: Th17 cells in inflammatory conditions. Rev Diabet Stud 3:72-75, 2006.
    • (2006) Rev Diabet Stud , vol.3 , pp. 72-75
    • Cooke, A.1
  • 51
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J and Tolosa E: Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 132:3329-3341, 2009.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1    Stuerner, K.2    Kolster, M.3    Wolthausen, J.4    Tolosa, E.5
  • 53
    • 33646164439 scopus 로고    scopus 로고
    • Expanding the effector CD4 T-cell repertoire: The Th17 lineage
    • Harrington LE, Mangan PR and Weaver CT: Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opn Immunol 18:349-356, 2006.
    • (2006) Curr Opn Immunol , vol.18 , pp. 349-356
    • Harrington, L.E.1    Mangan, P.R.2    Weaver, C.T.3
  • 54
    • 0033402420 scopus 로고    scopus 로고
    • Interleukin. 6 expression and regulation in astrocytes
    • Van Wagoner NJ and Benveniste EN: Interleukin. 6 expression and regulation in astrocytes. J Neuroimmunol 100:124-139, 1999.
    • (1999) J Neuroimmunol , vol.100 , pp. 124-139
    • Van Wagoner, N.J.1    Benveniste, E.N.2
  • 55
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1(CD28), B7-2 (CD86) and interleukin 12 cytokine in multiple sclerosis lesions
    • Windhagen A, Newcombe J, Dangond F, Strand C, Woodroof MN, Cuzner ML and Hafler DA: Expression of costimulatory molecules B7.1(CD28), B7.2 (CD86) and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 182:1985-1996, 1995.
    • (1995) J Exp Med , vol.182 , pp. 1985-1996
    • Windhagen, A.1    Newcombe, J.2    Dangond, F.3    Strand, C.4    Woodroof, M.N.5    Cuzner, M.L.6    Hafler, D.A.7
  • 56
    • 0031713845 scopus 로고    scopus 로고
    • Transgenic models to study the actions of cytokines in the central nervous system
    • DOI 10.1159/000026329
    • Campbell IL, Stalder AK, Akwa Y, Pagenstecher A and Asensio VC: Transgenic models to study the actions of cytokines in the central nervous system. Neuroimmunomodulation 5:126-135, 1998. (Pubitemid 28417024)
    • (1998) NeuroImmunoModulation , vol.5 , Issue.3-4 , pp. 126-135
    • Campbell, I.L.1    Stalder, A.K.2    Akwa, Y.3    Pagenstecher, A.4    Asensio, V.C.5
  • 57
    • 0036154417 scopus 로고    scopus 로고
    • Interferon-β therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and Interleukin-10 production
    • DOI 10.1002/ana.10084
    • Byrnes AA, Mcarthur JC and Karp CL: Interferon. beta therapy for multiple sclerosis induces reciprocal changes in interleukin. 12 and interleukin. 10 production. Ann Neurol 51:165-174, 2002. (Pubitemid 34111438)
    • (2002) Annals of Neurology , vol.51 , Issue.2 , pp. 165-174
    • Byrnes, A.A.1    McArthur, J.C.2    Karp, C.L.3
  • 58
    • 0034234528 scopus 로고    scopus 로고
    • IFN-β-1b inhibits IL-12 production in peripheral blood mononuclear cells in an IL-10-dependent mechanism: Relevance to IFN-β-1b therapeutic effects in multiple sclerosis
    • Wang X, Chen M, Wandinger KP, Willians G and Dhib-Jalbut S: IFN-beta.1b inhibits IL.12 production in peripheral blood mononuclear cells in an IL.10.dependent mechanism: relevance to IFN-beta.1b therapeutic effects in multiple sclerosis. J Immunol 165:548-557, 2000. (Pubitemid 30429550)
    • (2000) Journal of Immunology , vol.165 , Issue.1 , pp. 548-557
    • Wang, X.1    Chen, M.2    Wandinger, K.P.3    Williams, G.4    Dhib-Jalbut, S.5
  • 59
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N and Glimcher LH: B7.1 and B7.2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707-718, 1995.
    • (1995) Cell , vol.80 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3    Ranger, A.M.4    Zamvil, S.S.5    Sobel, R.A.6    Weiner, H.L.7    Nabavi, N.8    Glimcher, L.H.9
  • 60
    • 78650515915 scopus 로고    scopus 로고
    • Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis
    • Mikulkova Z, Praksova P, Stourac P, Bednarik J and Michalek J: Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. J Neurol Sci 300:135-141, 2011.
    • (2011) J Neurol Sci , vol.300 , pp. 135-141
    • Mikulkova, Z.1    Praksova, P.2    Stourac, P.3    Bednarik, J.4    Michalek, J.5
  • 61
    • 0042138931 scopus 로고    scopus 로고
    • Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental autoimmune encephalomyelitis
    • Begolka WS and Miller SD: Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental autoimmune encephalomyelitis. Res Immunol 149:771-781, 1998.
    • (1998) Res Immunol , vol.149 , pp. 771-781
    • Begolka, W.S.1    Miller, S.D.2
  • 62
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B and Raine CS: The adhesion molecule and cytokine profile of multiple sclerosis lesions. Annals Neurol 37:424-435, 1995.
    • (1995) Annals Neurol , vol.37 , pp. 424-435
    • Cannella, B.1    Raine, C.S.2
  • 63
    • 0344835910 scopus 로고    scopus 로고
    • Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: Roles of interleukin-10 in disease progression and recovery
    • DOI 10.1006/cimm.1998.1365
    • Samoilova EB, Horton JL and Chen Y: Acceleration of experimental autoimmune encephalomyelitis in interleukin. 10.deficient mice: roles of interleukin. 10 in disease progression and recovery. Cell Immunol 188:118-124, 1998. (Pubitemid 28493564)
    • (1998) Cellular Immunology , vol.188 , Issue.2 , pp. 118-124
    • Samoilova, E.B.1    Horton, J.L.2    Chen, Y.3
  • 64
    • 84873168805 scopus 로고    scopus 로고
    • Multiple sclerosis - Forms and phases of the disease
    • Pedrosa R ed. Elaborated by the Neurology Portuguese Society. 1st edition. Biogen Indec Portugal, Lisboa
    • Marques M: Multiple sclerosis - Forms and phases of the disease. In: Multiple Sclerosis Introduction. Pedrosa R (ed). Elaborated by the Neurology Portuguese Society. 1st edition. Biogen Indec Portugal, Lisboa, pp155-161, 2010.
    • (2010) Multiple Sclerosis Introduction , pp. 155-161
    • Marques, M.1
  • 66
    • 0023794099 scopus 로고    scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestations in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H and Wietzerbin J: Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestations in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol Scand 78:318-323, 1998.
    • (1998) Acta Neurol Scand , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3    Falcoff, E.4    Kirchner, H.5    Wietzerbin, J.6
  • 67
    • 0032966258 scopus 로고    scopus 로고
    • Interferon-γ secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-β therapy
    • DOI 10.1002/1531-8249(199902)45:2<247::AID-ANA16>3.0.CO;2-U
    • Becher B, Giacomini PS, Pelletier D, Mccrea E, Prat A and Antel JP: Interferon. gamma secretion by peripheral blood T-cell subsets in multiple sclerosis: correlation with disease phase and interferon. beta therapy. Ann Neurol 45:247-250, 1999. (Pubitemid 29072372)
    • (1999) Annals of Neurology , vol.45 , Issue.2 , pp. 247-250
    • Becher, B.1    Giacomini, P.S.2    Pelletier, D.3    McCrea, E.4    Prat, A.5    Antel, J.P.6
  • 70
    • 0025778577 scopus 로고
    • Tumor necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis
    • Benvenuto R, Paroli M, Buttinelli C, Franco A, Barnaba V, Fieschi C and Balsano F: Tumor necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. Clin Exp Immunol 84:97-102, 1991.
    • (1991) Clin Exp Immunol , vol.84 , pp. 97-102
    • Benvenuto, R.1    Paroli, M.2    Buttinelli, C.3    Franco, A.4    Barnaba, V.5    Fieschi, C.6    Balsano, F.7
  • 71
    • 0025852567 scopus 로고
    • Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
    • Selmaj K, Raine CS, Cannella B and Brosnan CF: Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 87:949-954, 1991.
    • (1991) J Clin Invest , vol.87 , pp. 949-954
    • Selmaj, K.1    Raine, C.S.2    Cannella, B.3    Brosnan, C.F.4
  • 72
    • 0034634740 scopus 로고    scopus 로고
    • Interleukin. 6 expression in human multiple sclerosis lesions
    • Schonrock LM, Gawlowski G and Bruck W: Interleukin. 6 expression in human multiple sclerosis lesions. Neurosci Lett 294:45-48, 2000.
    • (2000) Neurosci Lett , vol.294 , pp. 45-48
    • Schonrock, L.M.1    Gawlowski, G.2    Bruck, W.3
  • 74
    • 33646417072 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in inflammation
    • Iwakura Y and Ishigame H: The IL-23/IL-17 axis in inflammation. J Clin Invest 116:1218-1222, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 1218-1222
    • Iwakura, Y.1    Ishigame, H.2
  • 76
    • 0034254825 scopus 로고    scopus 로고
    • Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production
    • Pelfrey CM, Rudick RA, Cotleur AC, Lee JC, Tary-Lehmann M and Lehmann PV: Quantification of self-recognition in multiple sclerosis by single cell analysis of cytokine production. J Immunol 165:1641-1651, 2000. (Pubitemid 30604603)
    • (2000) Journal of Immunology , vol.165 , Issue.3 , pp. 1641-1651
    • Pelfrey, C.M.1    Rudick, R.A.2    Cotleur, A.C.3    Lee, J.-C.4    Tary-Lehmann, M.5    Lehmann, P.V.6


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