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Volumn 127, Issue 7, 2004, Pages 1463-1478

Development of biomarkers in multiple sclerosis

Author keywords

Autoimmunity; Immunological biomarkers; Multiple sclerosis; Surrogate markers

Indexed keywords

AUTOANTIBODY; BRAIN DERIVED NEUROTROPHIC FACTOR; CELL ADHESION MOLECULE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; COMPLEMENT; COMPLEMENT COMPONENT C9; CYTOKINE; CYTOKINE RECEPTOR; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; ISOPROSTANE; NEOPTERIN; NITRIC OXIDE; TAU PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; URIC ACID;

EID: 3142556134     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh176     Document Type: Review
Times cited : (271)

References (51)
  • 1
    • 0033615468 scopus 로고    scopus 로고
    • Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance
    • Barkhof F, van Walderveen M. Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance. Philos Trans R Soc Lond B Biol Sci 1999; 354: 1675-86.
    • (1999) Philos Trans R Soc Lond B Biol Sci , vol.354 , pp. 1675-1686
    • Barkhof, F.1    Van Walderveen, M.2
  • 3
    • 0034789792 scopus 로고    scopus 로고
    • Antigen-specific immunomodulation via altered peptide ligands
    • Bielekova B, Martin R. Antigen-specific immunomodulation via altered peptide ligands. J Mol Med 2001; 79: 552-65.
    • (2001) J Mol Med , vol.79 , pp. 552-565
    • Bielekova, B.1    Martin, R.2
  • 4
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000; 6: 1167-75.
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6
  • 5
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69: 89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 6
    • 10744231299 scopus 로고    scopus 로고
    • Gene expression profile in multiple sclerosis patients and healthy controls: Identifying pathways relevant to disease
    • Bomprezzi R, Ringner M, Kim S, Bittner ML, Khan J, Chen Y, et al. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum Mol Genet 2003; 12: 2191-9.
    • (2003) Hum Mol Genet , vol.12 , pp. 2191-2199
    • Bomprezzi, R.1    Ringner, M.2    Kim, S.3    Bittner, M.L.4    Khan, J.5    Chen, Y.6
  • 7
    • 0001863948 scopus 로고    scopus 로고
    • The validation of surrogate endpoints in meta-analyses of randomized experiments
    • Buyse M, Molenberghs G, Burzykowski T, Renard D, Geys H. The validation of surrogate endpoints in meta-analyses of randomized experiments. Biostatistics 2000; 1: 49-67.
    • (2000) Biostatistics , vol.1 , pp. 49-67
    • Buyse, M.1    Molenberghs, G.2    Burzykowski, T.3    Renard, D.4    Geys, H.5
  • 8
    • 0031029644 scopus 로고    scopus 로고
    • Perspective: Validating surrogate markers - Are we being naive?
    • De Gruttola V, Fleming T, Lin DY, Coombs R. Perspective: validating surrogate markers-are we being naive? J Infect Dis 1997; 175: 237-46.
    • (1997) J Infect Dis , vol.175 , pp. 237-246
    • De Gruttola, V.1    Fleming, T.2    Lin, D.Y.3    Coombs, R.4
  • 9
    • 0034929220 scopus 로고    scopus 로고
    • Silver stained isoelectrophoresis of tears and cerebrospinal fluid in multiple sclerosis
    • Devos D, Forzy G, de Seze J, Caillez S, Louchart P, Gallois P, et al. Silver stained isoelectrophoresis of tears and cerebrospinal fluid in multiple sclerosis. J Neurol 2001; 248: 672-5.
    • (2001) J Neurol , vol.248 , pp. 672-675
    • Devos, D.1    Forzy, G.2    De Seze, J.3    Caillez, S.4    Louchart, P.5    Gallois, P.6
  • 10
    • 0037181634 scopus 로고    scopus 로고
    • Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: Results of a 2-year prospective randomised multicentre study (INCOMIN)
    • Durelli L, Verdun E, Barbero P, Bergui M, Versino E, Ghezzi A, et al. Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 2002; 359: 1453-60.
    • (2002) Lancet , vol.359 , pp. 1453-1460
    • Durelli, L.1    Verdun, E.2    Barbero, P.3    Bergui, M.4    Versino, E.5    Ghezzi, A.6
  • 11
    • 85039776671 scopus 로고    scopus 로고
    • Food and Drug Administration. Modernization Act of 1997. Title 21 Code of Federal Regulations Part 314 Subpart H Section 314.500, 1997
    • Food and Drug Administration. Modernization Act of 1997. Title 21 Code of Federal Regulations Part 314 Subpart H Section 314.500, 1997.
  • 12
    • 0038004636 scopus 로고    scopus 로고
    • Clinical biomarkers in drug discovery and development
    • Frank R, Hargreaves R. Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2003; 2: 566-80.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 566-580
    • Frank, R.1    Hargreaves, R.2
  • 13
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • Genain CP, Cannella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 1999; 5: 170-5.
    • (1999) Nat Med , vol.5 , pp. 170-175
    • Genain, C.P.1    Cannella, B.2    Hauser, S.L.3    Raine, C.S.4
  • 14
    • 0037167538 scopus 로고    scopus 로고
    • Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS
    • Ghalie RG, Edan G, Laurent M, Mauch E, Eisenman S, Hartung HP, et al. Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS. Neurology 2002; 59: 909-13.
    • (2002) Neurology , vol.59 , pp. 909-913
    • Ghalie, R.G.1    Edan, G.2    Laurent, M.3    Mauch, E.4    Eisenman, S.5    Hartung, H.P.6
  • 15
    • 0031664040 scopus 로고    scopus 로고
    • Urinary markers of disease activity in multiple sclerosis
    • Giovannoni G, Thompson EJ. Urinary markers of disease activity in multiple sclerosis. Mult Scler 1998; 4: 247-53.
    • (1998) Mult Scler , vol.4 , pp. 247-253
    • Giovannoni, G.1    Thompson, E.J.2
  • 16
    • 0030859353 scopus 로고    scopus 로고
    • Longitudinal study of soluble adhesion molecules in multiple sclerosis: Correlation with gadolinium enhanced magnetic resonance imaging
    • Giovannoni G, Lai M, Thorpe J, Kidd D, Chamoun V, Thompson AJ, et al. Longitudinal study of soluble adhesion molecules in multiple sclerosis: correlation with gadolinium enhanced magnetic resonance imaging. Neurology 1997; 48: 1557-65.
    • (1997) Neurology , vol.48 , pp. 1557-1565
    • Giovannoni, G.1    Lai, M.2    Thorpe, J.3    Kidd, D.4    Chamoun, V.5    Thompson, A.J.6
  • 17
    • 0031713584 scopus 로고    scopus 로고
    • Are there any body fluid markers of brain atrophy in multiple sclerosis?
    • Giovannoni G, Green AJ, Thompson EJ. Are there any body fluid markers of brain atrophy in multiple sclerosis? Mult Scler 1998a; 4: 138-42.
    • (1998) Mult Scler , vol.4 , pp. 138-142
    • Giovannoni, G.1    Green, A.J.2    Thompson, E.J.3
  • 18
    • 0031778459 scopus 로고    scopus 로고
    • Correlating immunological and magnetic resonance imaging markers of disease activity in multiple sclerosis
    • Giovannoni G, Kieseier B, Hartung HP. Correlating immunological and magnetic resonance imaging markers of disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 1998b; 64 Suppl 1: S31-6.
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , Issue.SUPPL. 1
    • Giovannoni, G.1    Kieseier, B.2    Hartung, H.P.3
  • 19
    • 0029119076 scopus 로고
    • Users' guides to the medical literature. VIII. How to use clinical practice guidelines. A. Are the recommendations valid?
    • The Evidence-Based Medicine Working Group
    • Hayward RS, Wilson MC, Tunis SR, Bass EB, Guyatt G. Users' guides to the medical literature. VIII. How to use clinical practice guidelines. A. Are the recommendations valid? The Evidence-Based Medicine Working Group. JAMA 1995; 274: 570-4.
    • (1995) JAMA , vol.274 , pp. 570-574
    • Hayward, R.S.1    Wilson, M.C.2    Tunis, S.R.3    Bass, E.B.4    Guyatt, G.5
  • 20
    • 0036906691 scopus 로고    scopus 로고
    • Evaluating surrogate endpoints
    • Hughes MD. Evaluating surrogate endpoints. Control Clin Trials 2002; 23: 703-7.
    • (2002) Control Clin Trials , vol.23 , pp. 703-707
    • Hughes, M.D.1
  • 23
    • 0028012745 scopus 로고
    • Users' guides to the medical literature. III. How to use an article about a diagnostic test. A. Are the results of the study valid?
    • Evidence-Based Medicine Working Group
    • Jaeschke R, Guyatt G, Sackett DL. Users' guides to the medical literature. III. How to use an article about a diagnostic test. A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA 1994a; 271: 389-91.
    • (1994) JAMA , vol.271 , pp. 389-391
    • Jaeschke, R.1    Guyatt, G.2    Sackett, D.L.3
  • 24
    • 0028760247 scopus 로고
    • Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients?
    • The Evidence-Based Medicine Working Group
    • Jaeschke R, Guyatt GH, Sackett DL. Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group. JAMA 1994b; 271: 703-7.
    • (1994) JAMA , vol.271 , pp. 703-707
    • Jaeschke, R.1    Guyatt, G.H.2    Sackett, D.L.3
  • 25
    • 0036799650 scopus 로고    scopus 로고
    • Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
    • John GR, Shankar SL, Shafit-Zagardo B, Massimi A, Lee SC, Raine CS, et al. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat Med 2002; 8: 1115-21.
    • (2002) Nat Med , vol.8 , pp. 1115-1121
    • John, G.R.1    Shankar, S.L.2    Shafit-Zagardo, B.3    Massimi, A.4    Lee, S.C.5    Raine, C.S.6
  • 26
    • 0031825481 scopus 로고    scopus 로고
    • Soluble and cell surface ICAM-1 as markers for disease activity in multiple sclerosis
    • Kraus J, Oschmann P, Engelhardt B, Schiel C, Hornig C, Bauer R, et al. Soluble and cell surface ICAM-1 as markers for disease activity in multiple sclerosis. Acta Neurol Scand 1998; 98: 102-9.
    • (1998) Acta Neurol Scand , vol.98 , pp. 102-109
    • Kraus, J.1    Oschmann, P.2    Engelhardt, B.3    Schiel, C.4    Hornig, C.5    Bauer, R.6
  • 27
    • 0036074810 scopus 로고    scopus 로고
    • Mechanisms of demyelination and tissue destruction in multiple sclerosis
    • Lassmann H. Mechanisms of demyelination and tissue destruction in multiple sclerosis. Clin Neurol Neurosurg 2002; 104: 168-71.
    • (2002) Clin Neurol Neurosurg , vol.104 , pp. 168-171
    • Lassmann, H.1
  • 29
    • 0038015505 scopus 로고    scopus 로고
    • A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions
    • Lassmann H, Reindl M, Rauschka H, Berger J, Aboul-Enein F, Berger T, et al. A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions. Brain 2003; 126: 1347-57.
    • (2003) Brain , vol.126 , pp. 1347-1357
    • Lassmann, H.1    Reindl, M.2    Rauschka, H.3    Berger, J.4    Aboul-Enein, F.5    Berger, T.6
  • 30
    • 0035037328 scopus 로고    scopus 로고
    • Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: Criteria, validation, strategies
    • Lesko LJ, Atkinson AJ Jr. Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies. Annu Rev Pharmacol Toxicol 2001; 41: 347-66.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 347-366
    • Lesko, L.J.1    Atkinson Jr., A.J.2
  • 31
    • 0035849494 scopus 로고    scopus 로고
    • Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results
    • Li DK, Zhao GJ, Paty DW. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results. Neurology 2001; 56: 1505-13.
    • (2001) Neurology , vol.56 , pp. 1505-1513
    • Li, D.K.1    Zhao, G.J.2    Paty, D.W.3
  • 32
    • 0026580455 scopus 로고
    • Immunological abnormalities in the tears of multiple sclerosis patients
    • Liedtke W, Weller M, Wietholter H, Dichgans J. Immunological abnormalities in the tears of multiple sclerosis patients. Acta Neurol Scand 1992; 85: 228-30.
    • (1992) Acta Neurol Scand , vol.85 , pp. 228-230
    • Liedtke, W.1    Weller, M.2    Wietholter, H.3    Dichgans, J.4
  • 33
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 2002; 8: 500-8.
    • (2002) Nat Med , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3    Brendolan, A.4    Schadt, E.5    Garren, H.6
  • 34
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707-17.
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 35
    • 0036644048 scopus 로고    scopus 로고
    • Cutting edge: Molecular portrait of human autoimmune disease
    • Maas K, Chan S, Parker J, Slater A, Moore J, Olsen N, et al. Cutting edge: molecular portrait of human autoimmune disease. J Immunol 2002; 169: 5-9.
    • (2002) J Immunol , vol.169 , pp. 5-9
    • Maas, K.1    Chan, S.2    Parker, J.3    Slater, A.4    Moore, J.5    Olsen, N.6
  • 36
    • 0036189054 scopus 로고    scopus 로고
    • The role of MRI as a surrogate outcome measure in multiple sclerosis
    • McFarland HF, Barkhof F, Antel J, Miller DH. The role of MRI as a surrogate outcome measure in multiple sclerosis. Mult Scler 2002; 8: 40-50.
    • (2002) Mult Scler , vol.8 , pp. 40-50
    • McFarland, H.F.1    Barkhof, F.2    Antel, J.3    Miller, D.H.4
  • 38
    • 0242432319 scopus 로고    scopus 로고
    • cDNA microarray analysis in multiple sclerosis lesions: Detection of genes associated with disease activity
    • Mycko MP, Papoian R, Boschert U, Raine CS, Selmaj KW. cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain 2003; 126: 1048-57.
    • (2003) Brain , vol.126 , pp. 1048-1057
    • Mycko, M.P.1    Papoian, R.2    Boschert, U.3    Raine, C.S.4    Selmaj, K.W.5
  • 39
    • 0032234507 scopus 로고    scopus 로고
    • NIH-FDA Conference. Biomarkers and surrogate endpoints: Advancing clinical research and applications
    • Abstracts
    • NIH-FDA Conference. Biomarkers and surrogate endpoints: advancing clinical research and applications. Abstracts. Dis Markers 1998; 14: 187-334.
    • (1998) Dis Markers , vol.14 , pp. 187-334
  • 40
    • 0034624942 scopus 로고    scopus 로고
    • Linomide in relapsing and secondary progressive MS: Part I: Trial design and clinical results
    • North American Linomide Investigators
    • Noseworthy JH, Wolinsky JS, Lublin FD, Whitaker JN, Linde A, Gjorstrup P, et al. Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators. Neurology 2000; 54: 1726-33.
    • (2000) Neurology , vol.54 , pp. 1726-1733
    • Noseworthy, J.H.1    Wolinsky, J.S.2    Lublin, F.D.3    Whitaker, J.N.4    Linde, A.5    Gjorstrup, P.6
  • 41
    • 0033546980 scopus 로고    scopus 로고
    • Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H
    • Paolillo A, Coles AJ, Molyneux PD, Gawne-Cain M, MacManus D, Barker GJ, et al. Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H. Neurology 1999; 53: 751-7.
    • (1999) Neurology , vol.53 , pp. 751-757
    • Paolillo, A.1    Coles, A.J.2    Molyneux, P.D.3    Gawne-Cain, M.4    MacManus, D.5    Barker, G.J.6
  • 42
    • 0033958462 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in a model of multiple sclerosis
    • Pitt D, Werner P, Raine CS. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 2000; 6: 67-70.
    • (2000) Nat Med , vol.6 , pp. 67-70
    • Pitt, D.1    Werner, P.2    Raine, C.S.3
  • 43
    • 0024520844 scopus 로고
    • Surrogate endpoints in clinical trials: Definition and operational criteria
    • Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1989; 8: 431-40.
    • (1989) Stat Med , vol.8 , pp. 431-440
    • Prentice, R.L.1
  • 44
    • 0031056637 scopus 로고    scopus 로고
    • Soluble adhesion molecules (sVCAM-1 and sICAM-1) in cerebrospinal fluid and serum correlate with MRI activity in multiple sclerosis
    • Rieckmann P, Altenhofen B, Riegel A, Baudewig J, Felgenhauer K. Soluble adhesion molecules (sVCAM-1 and sICAM-1) in cerebrospinal fluid and serum correlate with MRI activity in multiple sclerosis. Ann Neurol 1997; 41: 326-33.
    • (1997) Ann Neurol , vol.41 , pp. 326-333
    • Rieckmann, P.1    Altenhofen, B.2    Riegel, A.3    Baudewig, J.4    Felgenhauer, K.5
  • 45
    • 0037384066 scopus 로고    scopus 로고
    • Use of biomarkers from drug discovery through clinical practice: Report of the Ninth European Federation of Pharmaceutical Sciences Conference on Optimizing Drug Development
    • Rolan P, Atkinson AJ Jr, Lesko LJ. Use of biomarkers from drug discovery through clinical practice: report of the Ninth European Federation of Pharmaceutical Sciences Conference on Optimizing Drug Development. Clin Pharmacol Ther 2003; 73: 284-91.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 284-291
    • Rolan, P.1    Atkinson Jr., A.J.2    Lesko, L.J.3
  • 46
    • 0038692013 scopus 로고    scopus 로고
    • Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis
    • Sturzebecher S, Wandinger KP, Rosenwald A, Sathyamoorthy M, Tzou A, Mattar P, et al. Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis. Brain 2003; 126: 1419-29.
    • (2003) Brain , vol.126 , pp. 1419-1429
    • Sturzebecher, S.1    Wandinger, K.P.2    Rosenwald, A.3    Sathyamoorthy, M.4    Tzou, A.5    Mattar, P.6
  • 48
    • 0034855936 scopus 로고    scopus 로고
    • Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes
    • Wandinger KP, Sturzebecher CS, Bielekova B, Detore G, Rosenwald A, Staudt LM, et al. Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes. Ann Neurol 2001; 50: 349-57.
    • (2001) Ann Neurol , vol.50 , pp. 349-357
    • Wandinger, K.P.1    Sturzebecher, C.S.2    Bielekova, B.3    Detore, G.4    Rosenwald, A.5    Staudt, L.M.6
  • 49
    • 12444304354 scopus 로고    scopus 로고
    • TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis
    • Wandinger KP, Lunemann JD, Wengert O, Bellmann-Strobl J, Aktas O, Weber A, et al. TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis. Lancet 2003; 361: 2036-43.
    • (2003) Lancet , vol.361 , pp. 2036-2043
    • Wandinger, K.P.1    Lunemann, J.D.2    Wengert, O.3    Bellmann-Strobl, J.4    Aktas, O.5    Weber, A.6
  • 50
    • 0035803832 scopus 로고    scopus 로고
    • Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions
    • Whitney LW, Ludwin SK, McFarland HF, Biddison WE. Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions. J Neuroimmunol 2001; 121: 40-8.
    • (2001) J Neuroimmunol , vol.121 , pp. 40-48
    • Whitney, L.W.1    Ludwin, S.K.2    McFarland, H.F.3    Biddison, W.E.4
  • 51
    • 0034624943 scopus 로고    scopus 로고
    • Linomide in relapsing and secondary progressive MS: Part II: MRI results
    • MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators
    • Wolinsky JS, Narayana PA, Noseworthy JH, Lublin FD, Whitaker JN, Linde A, et al. Linomide in relapsing and secondary progressive MS: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators. Neurology 2000; 54: 1734-41.
    • (2000) Neurology , vol.54 , pp. 1734-1741
    • Wolinsky, J.S.1    Narayana, P.A.2    Noseworthy, J.H.3    Lublin, F.D.4    Whitaker, J.N.5    Linde, A.6


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