Serum level of interleukin-6 in Chinese patients with multiple sclerosis

Journal of Neuroimmunology

Volumn 249, Issue 1-2, 2012, Pages 109-111

  Chen, Ying Chun ^a,b   Yang, Xin ^a   Miao, Ling ^a   Liu, Zhen Guo ^a   Li, Wei ^a   Zhao, Zhong Xin ^c   Sun, Xiao Jiang ^a   Jiang, Guo Xin ^b,d   Chen, Sheng Di ^a   Cheng, Qi ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

IL 6; Multiple sclerosis; Relapse

Indexed keywords

INTERLEUKIN 6;

ADULT; AGE; AGED; ARTICLE; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DISABILITY; DISEASE ACTIVITY; DISEASE DURATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; INTERLEUKIN 6 BLOOD LEVEL; MALE; MULTIPLE SCLEROSIS; ONSET AGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RELAPSE; SEX DIFFERENCE;

ADULT; AGE OF ONSET; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; RECURRENCE; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 84863460278     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.04.015     Document Type: Article

References (11)

1. Chen Y.C., Chen S.D., Miao L., Liu Z.G., Li W., Zhao Z.X., Sun X.J., Jiang G.X., Cheng Q. Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis. J. Neuroimmunol. 2012, 243:56-60.
2. Malmestrom C., Andersson B.A., Haghighi S., Lycke J. IL-6 and CCL2 levels in CSF are associated with the clinical course of MS: implications for their possible immunopathogenic roles. J. Neuroimmunol. 2006, 175:176-182.
3. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A.J., van den Noort S., Weinshenker B.Y., Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann. Neurol. 2001, 50:121-127.
4. Michalopoulou M., Nikolaou C., Tavernarakis A., Alexandri N.M., Rentzos M., Chatzipanagiotou S., Cambouri C., Vassilopoulos D. Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases. Immunol. Lett. 2004, 94:183-189.
5. Nguyen L.T., Ramanathan M., Weinstock-Guttman B., Baier M., Brownscheidle C., Jacobs L.D. Sex differences in in vitro pro-inflammatory cytokine production from peripheral blood of multiple sclerosis patients. J. Neurol. Sci. 2003, 209:93-99.
6. Pelfrey C.M., Cotleur A.C., Lee J.C., Rudick R.A. Sex differences in cytokine responses to myelin peptides in multiple sclerosis. J. Neuroimmunol. 2002, 130:211-223.
7. Samoilova E.B., Horton J.L., Hilliard B., Liu T.S., Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 1998, 161:6480-6486.
8. Serada S., Fujimoto M., Mihara M., Koike N., Ohsugi Y., Nomura S., Yoshida H., Nishikawa T., Terabe F., Ohkawara T., Takahashi T., Ripley B., Kimura A., Kishimoto T., Naka T. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:9041-9046.
9. Stelmasiak Z., Koziol-Montewka M., Dobosz B., Rejdak K., Bartosik-Psujek H., Mitosek-Szewczyk K., Belniak-Legiec E. Interleukin-6 concentration in serum and cerebrospinal fluid in multiple sclerosis patients. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 2000, 6:1104-1108.
10. Stelmasiak Z., Koziol-Montewka M., Dobosz B., Rejdak K. IL-6 and sIL-6R concentration in the cerebrospinal fluid and serum of MS patients. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 2001, 7:914-918.
11. Vladic A., Horvat G., Vukadin S., Sucic Z., Simaga S. Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients. Cytokine 2002, 20:86-89.