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Volumn 33, Issue 1, 2013, Pages 44-53

The Role of the Renin-Angiotensin-Aldosterone System in Obesity-Related Renal Diseases

Author keywords

Angiotensin II; Glomerulosclerosis; Metabolic syndrome; Obesity

Indexed keywords

ALBUMIN; ALDOSTERONE; ALISKIREN; ANGIOTENSIN; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSIN[1-7]; CANDESARTAN; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; IRBESARTAN; LIPID; LISINOPRIL; LOSARTAN; OLMESARTAN; PLACEBO; RAMIPRIL; RENIN; ROSUVASTATIN; SPIRONOLACTONE; TELMISARTAN; TRANDOLAPRIL; VALSARTAN; VERAPAMIL;

EID: 84873106976     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2012.12.002     Document Type: Article
Times cited : (127)

References (121)
  • 1
    • 79951558318 scopus 로고    scopus 로고
    • Global burden of metabolic risk factors of chronic diseases collaborating group (body mass index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants
    • Finucane M.M., Stevens G.A., Cowan M.J., Danaei G., Lin J.K., Paciorek C.J., et al. Global burden of metabolic risk factors of chronic diseases collaborating group (body mass index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011, 377:557-567.
    • (2011) Lancet , vol.377 , pp. 557-567
    • Finucane, M.M.1    Stevens, G.A.2    Cowan, M.J.3    Danaei, G.4    Lin, J.K.5    Paciorek, C.J.6
  • 5
    • 84861092508 scopus 로고    scopus 로고
    • Epidemiology of obesity, the metabolic syndrome, and chronic kidney disease
    • Tanner R.M., Brown T.M., Muntner P. Epidemiology of obesity, the metabolic syndrome, and chronic kidney disease. Curr Hypertens Rep 2012, 14:152-159.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 152-159
    • Tanner, R.M.1    Brown, T.M.2    Muntner, P.3
  • 8
  • 9
    • 27944451884 scopus 로고    scopus 로고
    • Synergy of low nephron number and obesity: a new focus on hyperfiltration nephropathy
    • Praga M. Synergy of low nephron number and obesity: a new focus on hyperfiltration nephropathy. Nephrol Dial Transplant 2005, 20:2594-2597.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 2594-2597
    • Praga, M.1
  • 10
    • 0038512467 scopus 로고    scopus 로고
    • The effects of weight loss on renal function in patients with severe obesity
    • Chagnac A., Weinstein T., Herman M., Hirsh J., Gafter U., Ori Y. The effects of weight loss on renal function in patients with severe obesity. J Am Soc Nephrol 2003, 14:1480-1486.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1480-1486
    • Chagnac, A.1    Weinstein, T.2    Herman, M.3    Hirsh, J.4    Gafter, U.5    Ori, Y.6
  • 12
    • 84861096431 scopus 로고    scopus 로고
    • The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome
    • Thethi T., Kamiyama M., Kobori H. The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome. Curr Hypertens Rep 2012, 14:160-169.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 160-169
    • Thethi, T.1    Kamiyama, M.2    Kobori, H.3
  • 13
    • 33748047823 scopus 로고    scopus 로고
    • Role of the renin-angiotensin-aldosterone system in the metabolic syndrome
    • Engeli S. Role of the renin-angiotensin-aldosterone system in the metabolic syndrome. Contrib Nephrol 2006, 151:122-134.
    • (2006) Contrib Nephrol , vol.151 , pp. 122-134
    • Engeli, S.1
  • 14
    • 20844460800 scopus 로고    scopus 로고
    • Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    • Wolf G., Ritz E. Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications. Kidney Int 2005, 67:799-812.
    • (2005) Kidney Int , vol.67 , pp. 799-812
    • Wolf, G.1    Ritz, E.2
  • 15
    • 79960112806 scopus 로고    scopus 로고
    • Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis
    • Rüster C., Wolf G. Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis. J Am Soc Nephrol 2011, 22:1189-1199.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1189-1199
    • Rüster, C.1    Wolf, G.2
  • 16
    • 77957374580 scopus 로고    scopus 로고
    • Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7)
    • Ferrario C.M., Ahmad S., Joyner J., Varagic J. Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Adv Pharmacol 2010, 59:197-233.
    • (2010) Adv Pharmacol , vol.59 , pp. 197-233
    • Ferrario, C.M.1    Ahmad, S.2    Joyner, J.3    Varagic, J.4
  • 18
    • 74949092226 scopus 로고    scopus 로고
    • New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism
    • Ferrario C.M. New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension 2010, 55:445-452.
    • (2010) Hypertension , vol.55 , pp. 445-452
    • Ferrario, C.M.1
  • 19
    • 84862225648 scopus 로고    scopus 로고
    • Exploring metabolic dysfunction in chronic kidney disease
    • Slee A.D. Exploring metabolic dysfunction in chronic kidney disease. Nutr Metab (Lond) 2012, 9:36.
    • (2012) Nutr Metab (Lond) , vol.9 , pp. 36
    • Slee, A.D.1
  • 21
    • 17944364171 scopus 로고    scopus 로고
    • Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity
    • Massiera F., Seydoux J., Geloen A., Quignard-Boulange A., Turban S., Saint-Marc P., et al. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology 2001, 142:5220-5225.
    • (2001) Endocrinology , vol.142 , pp. 5220-5225
    • Massiera, F.1    Seydoux, J.2    Geloen, A.3    Quignard-Boulange, A.4    Turban, S.5    Saint-Marc, P.6
  • 22
    • 0035650575 scopus 로고    scopus 로고
    • Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
    • Massiéra F., Bloch-Faure M., Ceiler D., Murakami K., Fukamizu A., Gasc J.M., et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 2001, 15:2727-2729.
    • (2001) FASEB J , vol.15 , pp. 2727-2729
    • Massiéra, F.1    Bloch-Faure, M.2    Ceiler, D.3    Murakami, K.4    Fukamizu, A.5    Gasc, J.M.6
  • 24
    • 77949654518 scopus 로고    scopus 로고
    • Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy
    • Yasue S., Masuzaki H., Okada S., Ishii T., Kozuka C., Tanaka T., et al. Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy. Am J Hypertens 2010, 23:425-431.
    • (2010) Am J Hypertens , vol.23 , pp. 425-431
    • Yasue, S.1    Masuzaki, H.2    Okada, S.3    Ishii, T.4    Kozuka, C.5    Tanaka, T.6
  • 25
    • 15944377334 scopus 로고    scopus 로고
    • Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance
    • Yvan-Charvet L., Even P., Bloch-Faure M., Guerre-Millo M., Moustaid-Moussa N., Ferre P., et al. Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Diabetes 2005, 54:991-999.
    • (2005) Diabetes , vol.54 , pp. 991-999
    • Yvan-Charvet, L.1    Even, P.2    Bloch-Faure, M.3    Guerre-Millo, M.4    Moustaid-Moussa, N.5    Ferre, P.6
  • 26
    • 23044505229 scopus 로고    scopus 로고
    • Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor
    • Kouyama R., Suganami T., Nishida J., Tanaka M., Toyoda T., Kiso M., et al. Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Endocrinology 2005, 146:3481-3489.
    • (2005) Endocrinology , vol.146 , pp. 3481-3489
    • Kouyama, R.1    Suganami, T.2    Nishida, J.3    Tanaka, M.4    Toyoda, T.5    Kiso, M.6
  • 27
    • 33847018997 scopus 로고    scopus 로고
    • Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
    • Sampaio W.O., Santos R.A.S., Faria-Silva R., Mata Machado L.T., Schiffrin E.L., Touyz R.M. Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 2007, 49:185-192.
    • (2007) Hypertension , vol.49 , pp. 185-192
    • Sampaio, W.O.1    Santos, R.A.S.2    Faria-Silva, R.3    Mata Machado, L.T.4    Schiffrin, E.L.5    Touyz, R.M.6
  • 29
    • 84865259212 scopus 로고    scopus 로고
    • Captopril intake decreases body weight gain via angiotensin-(1-7)
    • Oh Y.B., Kim J.H., Park B.M., Park B.H., Kim S.H. Captopril intake decreases body weight gain via angiotensin-(1-7). Peptides 2012, 37:79-85.
    • (2012) Peptides , vol.37 , pp. 79-85
    • Oh, Y.B.1    Kim, J.H.2    Park, B.M.3    Park, B.H.4    Kim, S.H.5
  • 31
    • 64349083373 scopus 로고    scopus 로고
    • Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus
    • Saiki A., Ohira M., Endo K., Koide N., Oyama T., Murano T., et al. Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus. Metabolism 2009, 58:708-713.
    • (2009) Metabolism , vol.58 , pp. 708-713
    • Saiki, A.1    Ohira, M.2    Endo, K.3    Koide, N.4    Oyama, T.5    Murano, T.6
  • 33
    • 84859166172 scopus 로고    scopus 로고
    • Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the Framingham Heart Study
    • 4
    • O'Seaghdha C.M., Hwang S.J., Vasan R.S., Larson M.G., Hoffmann U., Wang T.J., et al. Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the Framingham Heart Study. BMC Endocr Disord 2012, 12:3. 4.
    • (2012) BMC Endocr Disord , vol.12 , pp. 3
    • O'Seaghdha, C.M.1    Hwang, S.J.2    Vasan, R.S.3    Larson, M.G.4    Hoffmann, U.5    Wang, T.J.6
  • 35
    • 47649085301 scopus 로고    scopus 로고
    • Aldosterone and glomerular podocyte injury
    • Nagase M., Fujita T. Aldosterone and glomerular podocyte injury. Clin Exp Nephrol 2008, 12:233-242.
    • (2008) Clin Exp Nephrol , vol.12 , pp. 233-242
    • Nagase, M.1    Fujita, T.2
  • 36
    • 0346157984 scopus 로고    scopus 로고
    • Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration
    • de Paula R.B., da Silva A.A., Hall J.E. Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration. Hypertension 2004, 43:41-47.
    • (2004) Hypertension , vol.43 , pp. 41-47
    • de Paula, R.B.1    da Silva, A.A.2    Hall, J.E.3
  • 37
    • 53949092384 scopus 로고    scopus 로고
    • Renal injury in extreme obesity: the important role of aldosterone
    • author reply, 1216-7
    • Bomback A.S., Klemmer P.J. Renal injury in extreme obesity: the important role of aldosterone. Kidney Int 2008, 74:1216. author reply, 1216-7.
    • (2008) Kidney Int , vol.74 , pp. 1216
    • Bomback, A.S.1    Klemmer, P.J.2
  • 38
    • 84860226019 scopus 로고    scopus 로고
    • Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction
    • Briones A.M., Cat A.N., Callera G.E., Yogi A., Burger D., He Y., et al. Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension 2012, 59:1069-1078.
    • (2012) Hypertension , vol.59 , pp. 1069-1078
    • Briones, A.M.1    Cat, A.N.2    Callera, G.E.3    Yogi, A.4    Burger, D.5    He, Y.6
  • 39
    • 77950510305 scopus 로고    scopus 로고
    • Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome
    • Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension 2010, 55:813-818.
    • (2010) Hypertension , vol.55 , pp. 813-818
    • Fujita, T.1
  • 40
    • 11244311897 scopus 로고    scopus 로고
    • Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells
    • Ehrhart-Bornstein M., Arakelyan K., Krug A.W., Scherbaum W.A., Bornstein S.R. Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res 2004, 30:865-870.
    • (2004) Endocr Res , vol.30 , pp. 865-870
    • Ehrhart-Bornstein, M.1    Arakelyan, K.2    Krug, A.W.3    Scherbaum, W.A.4    Bornstein, S.R.5
  • 41
    • 33845238078 scopus 로고    scopus 로고
    • Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors
    • Nagase M., Yoshida S., Shibata S., Nagase T., Gotoda T., Ando K., et al. Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol 2006, 17:3438-3446.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3438-3446
    • Nagase, M.1    Yoshida, S.2    Shibata, S.3    Nagase, T.4    Gotoda, T.5    Ando, K.6
  • 42
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
    • Leopold J.A., Dam A., Maron B.A., Scribner A.W., Liao R., Handy D.E., et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med 2007, 13:189-197.
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3    Scribner, A.W.4    Liao, R.5    Handy, D.E.6
  • 43
    • 70449718904 scopus 로고    scopus 로고
    • Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice
    • Hirata A., Maeda N., Hiuge A., Hibuse T., Fujita K., Okada T., et al. Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res 2009, 84:164-172.
    • (2009) Cardiovasc Res , vol.84 , pp. 164-172
    • Hirata, A.1    Maeda, N.2    Hiuge, A.3    Hibuse, T.4    Fujita, K.5    Okada, T.6
  • 44
    • 44049097881 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
    • Guo C., Ricchiuti V., Lian B.Q., Yao T.M., Coutinho P., Romero J.R., et al. Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation 2008, 117:2253-2261.
    • (2008) Circulation , vol.117 , pp. 2253-2261
    • Guo, C.1    Ricchiuti, V.2    Lian, B.Q.3    Yao, T.M.4    Coutinho, P.5    Romero, J.R.6
  • 46
    • 0035017738 scopus 로고    scopus 로고
    • Functional and structural changes in the kidney in the early stages of obesity
    • Henegar J.R., Bigler S.A., Henegar L.K., Tyagi S.C., Hall J.E. Functional and structural changes in the kidney in the early stages of obesity. J Am Soc Nephrol 2001, 12:1211-1217.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1211-1217
    • Henegar, J.R.1    Bigler, S.A.2    Henegar, L.K.3    Tyagi, S.C.4    Hall, J.E.5
  • 47
    • 31944437712 scopus 로고    scopus 로고
    • Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    • Ahmed S.B., Fisher N.D., Stevanovic R., Hollenberg N.K. Body mass index and angiotensin-dependent control of the renal circulation in healthy humans. Hypertension 2005, 46:1316-1320.
    • (2005) Hypertension , vol.46 , pp. 1316-1320
    • Ahmed, S.B.1    Fisher, N.D.2    Stevanovic, R.3    Hollenberg, N.K.4
  • 48
    • 79960290029 scopus 로고    scopus 로고
    • New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II
    • Zhuo J.L., Li X.C. New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II. Peptides 2011, 32:1551-1565.
    • (2011) Peptides , vol.32 , pp. 1551-1565
    • Zhuo, J.L.1    Li, X.C.2
  • 49
    • 75649145898 scopus 로고    scopus 로고
    • Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats
    • Chung S., Park C.W., Shin S.J., Lim J.H., Chung H.W., Youn D.Y., et al. Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats. Nephrol Dial Transplant 2010, 25:389-399.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 389-399
    • Chung, S.1    Park, C.W.2    Shin, S.J.3    Lim, J.H.4    Chung, H.W.5    Youn, D.Y.6
  • 50
    • 34547649343 scopus 로고    scopus 로고
    • The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system
    • Kim S., Soltani-Bejnood M., Quignard-Boulange A., Massiera F., Teboul M., Ailhaud G., et al. The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system. J Biomed Biotechnol 2006, 2006:27012.
    • (2006) J Biomed Biotechnol , vol.2006 , pp. 27012
    • Kim, S.1    Soltani-Bejnood, M.2    Quignard-Boulange, A.3    Massiera, F.4    Teboul, M.5    Ailhaud, G.6
  • 51
    • 84861832781 scopus 로고    scopus 로고
    • Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation
    • Kawarazaki W., Nagase M., Yoshida S., Takeuchi M., Ishizawa K., Ayuzawa N., et al. Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation. J Am Soc Nephrol 2012, 23:997-1007.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 997-1007
    • Kawarazaki, W.1    Nagase, M.2    Yoshida, S.3    Takeuchi, M.4    Ishizawa, K.5    Ayuzawa, N.6
  • 52
    • 33947427486 scopus 로고    scopus 로고
    • Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system
    • Hirono Y., Yoshimoto T., Suzuki N., Sugiyama T., Sakurada M., Takai S., et al. Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system. Endocrinology 2007, 148:1688-1696.
    • (2007) Endocrinology , vol.148 , pp. 1688-1696
    • Hirono, Y.1    Yoshimoto, T.2    Suzuki, N.3    Sugiyama, T.4    Sakurada, M.5    Takai, S.6
  • 53
    • 79958167599 scopus 로고    scopus 로고
    • Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats
    • Kawarazaki H., Ando K., Fujita M., Matsui H., Nagae A., Muraoka K., et al. Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats. Am J Physiol Renal Physiol 2011, 300:1402-1409.
    • (2011) Am J Physiol Renal Physiol , vol.300 , pp. 1402-1409
    • Kawarazaki, H.1    Ando, K.2    Fujita, M.3    Matsui, H.4    Nagae, A.5    Muraoka, K.6
  • 54
    • 66049141708 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat
    • Whaley-Connell A., Habibi J., Wei Y., Gutweiler A., Jellison J., Wiedmeyer C.E., et al. Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat. Am J Physiol Renal Physiol 2009, 296:1013-1022.
    • (2009) Am J Physiol Renal Physiol , vol.296 , pp. 1013-1022
    • Whaley-Connell, A.1    Habibi, J.2    Wei, Y.3    Gutweiler, A.4    Jellison, J.5    Wiedmeyer, C.E.6
  • 55
    • 67649641510 scopus 로고    scopus 로고
    • Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats
    • Zhu A., Yoneda T., Demura M., Karashima S., Usukura M., Yamagishi M., et al. Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats. J Hypertens 2009, 27:800-805.
    • (2009) J Hypertens , vol.27 , pp. 800-805
    • Zhu, A.1    Yoneda, T.2    Demura, M.3    Karashima, S.4    Usukura, M.5    Yamagishi, M.6
  • 56
    • 64949189157 scopus 로고    scopus 로고
    • Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
    • Lea W.B., Kwak E.S., Luther J.M., Fowler S.M., Wang Z., Ma J., et al. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int 2009, 75:936-944.
    • (2009) Kidney Int , vol.75 , pp. 936-944
    • Lea, W.B.1    Kwak, E.S.2    Luther, J.M.3    Fowler, S.M.4    Wang, Z.5    Ma, J.6
  • 57
    • 84891729547 scopus 로고    scopus 로고
    • Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury
    • Luther J.M., Luo P., Wang Z., Cohen S.E., Kim H.S., Fogo A.B., et al. Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Kidney Int 2012, 37:79-85.
    • (2012) Kidney Int , vol.37 , pp. 79-85
    • Luther, J.M.1    Luo, P.2    Wang, Z.3    Cohen, S.E.4    Kim, H.S.5    Fogo, A.B.6
  • 58
    • 84863722393 scopus 로고    scopus 로고
    • Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury
    • Kagami S. Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury. Clin Exp Nephrol 2012, 16:214-220.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 214-220
    • Kagami, S.1
  • 59
    • 30944469631 scopus 로고    scopus 로고
    • Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
    • Huang Y., Wongamorntham S., Kasting J., McQuillan D., Owens R.T., Yu L., et al. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 2006, 69:105-113.
    • (2006) Kidney Int , vol.69 , pp. 105-113
    • Huang, Y.1    Wongamorntham, S.2    Kasting, J.3    McQuillan, D.4    Owens, R.T.5    Yu, L.6
  • 60
    • 77951104782 scopus 로고    scopus 로고
    • Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes
    • Sakoda M., Ichihara A., Kurauchi-Mito A., Narita T., Kinouchi K., Murohashi-Bokuda K. Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes. Am J Hypertens 2010, 23:575-580.
    • (2010) Am J Hypertens , vol.23 , pp. 575-580
    • Sakoda, M.1    Ichihara, A.2    Kurauchi-Mito, A.3    Narita, T.4    Kinouchi, K.5    Murohashi-Bokuda, K.6
  • 61
    • 84857060472 scopus 로고    scopus 로고
    • The interaction between prorenin, renin and the (pro)renin receptor: time to rethink the role in hypertension
    • Reudelhuber T.L. The interaction between prorenin, renin and the (pro)renin receptor: time to rethink the role in hypertension. Curr Opin Nephrol Hypertens 2012, 21:137-141.
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 137-141
    • Reudelhuber, T.L.1
  • 62
    • 33750722109 scopus 로고    scopus 로고
    • Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes
    • Ye M., Wysocki J., William J., Soler M.J., Cokic I., Batlle D. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol 2006, 17:3067-3075.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3067-3075
    • Ye, M.1    Wysocki, J.2    William, J.3    Soler, M.J.4    Cokic, I.5    Batlle, D.6
  • 63
    • 34548295365 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury
    • Wong D.W., Oudit G.Y., Reich H., Kassiri Z., Zhou J., Liu Q.C., et al. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol 2007, 171:438-451.
    • (2007) Am J Pathol , vol.171 , pp. 438-451
    • Wong, D.W.1    Oudit, G.Y.2    Reich, H.3    Kassiri, Z.4    Zhou, J.5    Liu, Q.C.6
  • 64
    • 84863722393 scopus 로고    scopus 로고
    • Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury
    • Kagami S. Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury. Clin Exp Nephrol 2012, 16:214-220.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 214-220
    • Kagami, S.1
  • 65
    • 77958486859 scopus 로고    scopus 로고
    • The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus
    • Lardizabal J.A., Deedwania P.C. The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus. Curr Cardiol Rep 2010, 12:464-471.
    • (2010) Curr Cardiol Rep , vol.12 , pp. 464-471
    • Lardizabal, J.A.1    Deedwania, P.C.2
  • 66
    • 81755177460 scopus 로고    scopus 로고
    • The renin-angiotensin-aldosterone system and glucose homeostasis
    • Luther J.M., Brown N.J. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol Sci 2011, 32:734-739.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 734-739
    • Luther, J.M.1    Brown, N.J.2
  • 67
    • 0034725652 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of angiotensin II signalling
    • Griendling K.K., Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signalling. Regul Pept 2000, 91:21-27.
    • (2000) Regul Pept , vol.91 , pp. 21-27
    • Griendling, K.K.1    Ushio-Fukai, M.2
  • 68
    • 77951754521 scopus 로고    scopus 로고
    • Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanism
    • Diamond-Stanic M.K., Henriksen E.J. Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanism. Arch Physiol Biochem 2010, 116:88-95.
    • (2010) Arch Physiol Biochem , vol.116 , pp. 88-95
    • Diamond-Stanic, M.K.1    Henriksen, E.J.2
  • 69
    • 0037410532 scopus 로고    scopus 로고
    • ACE inhibition may decrease diabetes risk by boosting the impact of bradykinin on adipocytes
    • McCarty M.F. ACE inhibition may decrease diabetes risk by boosting the impact of bradykinin on adipocytes. Med Hypotheses 2003, 60:779-783.
    • (2003) Med Hypotheses , vol.60 , pp. 779-783
    • McCarty, M.F.1
  • 70
    • 0242440352 scopus 로고    scopus 로고
    • Effects of ACE inhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients
    • Yavuz D., Koç M., Toprak A., Akpinar I., Velioǧlu A., Deyneli O., et al. Effects of ACE inhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients. J Renin Angiotensin Aldosterone Syst 2003, 4:197-203.
    • (2003) J Renin Angiotensin Aldosterone Syst , vol.4 , pp. 197-203
    • Yavuz, D.1    Koç, M.2    Toprak, A.3    Akpinar, I.4    Velioǧlu, A.5    Deyneli, O.6
  • 71
    • 84886950028 scopus 로고    scopus 로고
    • Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle
    • 10.1007/s11357-012-9428-4. Epub ahead of print
    • Marzetti E., Calvani R., Dupree J., Lees H.A., Giovannini S., Seo D.O., et al. Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age (Dordr) 2012 May 26, 10.1007/s11357-012-9428-4. Epub ahead of print.
    • (2012) Age (Dordr)
    • Marzetti, E.1    Calvani, R.2    Dupree, J.3    Lees, H.A.4    Giovannini, S.5    Seo, D.O.6
  • 72
    • 84857030484 scopus 로고    scopus 로고
    • Effects of losartan on whole body, skeletal muscle and vascular insulin responses in obesity/insulin resistance without hypertension
    • Lteif A.A., Chisholm R.L., Gilbert K., Considine R.V., Mather K.J. Effects of losartan on whole body, skeletal muscle and vascular insulin responses in obesity/insulin resistance without hypertension. Diabetes Obes Metab 2012, 14:254-261.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 254-261
    • Lteif, A.A.1    Chisholm, R.L.2    Gilbert, K.3    Considine, R.V.4    Mather, K.J.5
  • 73
    • 77956308889 scopus 로고    scopus 로고
    • Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms
    • Csibi A., Communi D., Müller N., Bottari S.P. Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms. PLoS One 2010, 5:10070.
    • (2010) PLoS One , vol.5 , pp. 10070
    • Csibi, A.1    Communi, D.2    Müller, N.3    Bottari, S.P.4
  • 74
    • 73649103154 scopus 로고    scopus 로고
    • Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats
    • Muñoz M.C., Giani J.F., Dominici F.P., Turyn D., Toblli J.E. Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats. J Hypertens 2009, 27:2409-2420.
    • (2009) J Hypertens , vol.27 , pp. 2409-2420
    • Muñoz, M.C.1    Giani, J.F.2    Dominici, F.P.3    Turyn, D.4    Toblli, J.E.5
  • 75
    • 84859393335 scopus 로고    scopus 로고
    • Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome
    • Rodriguez R., Viscarra J.A., Minas J.N., Nakano D., Nishiyama A., Ortiz R.M. Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome. Endocrinology 2012, 153:1684-1695.
    • (2012) Endocrinology , vol.153 , pp. 1684-1695
    • Rodriguez, R.1    Viscarra, J.A.2    Minas, J.N.3    Nakano, D.4    Nishiyama, A.5    Ortiz, R.M.6
  • 76
    • 77955512722 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice
    • Rong X., Li Y., Ebihara K., Zhao M., Naowaboot J., Kusakabe T., et al. Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice. Diabetologia 2010, 53:1727-1731.
    • (2010) Diabetologia , vol.53 , pp. 1727-1731
    • Rong, X.1    Li, Y.2    Ebihara, K.3    Zhao, M.4    Naowaboot, J.5    Kusakabe, T.6
  • 77
    • 66549130863 scopus 로고    scopus 로고
    • Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
    • Sowers J.R., Whaley-Connell A., Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med 2009, 150:776-783.
    • (2009) Ann Intern Med , vol.150 , pp. 776-783
    • Sowers, J.R.1    Whaley-Connell, A.2    Epstein, M.3
  • 78
    • 83155180252 scopus 로고    scopus 로고
    • Plasma aldosterone levels and development of insulin resistance: prospective study in a general population
    • Kumagai E., Adachi H., Jacobs D.R., Hirai Y., Enomoto M., Fukami A., et al. Plasma aldosterone levels and development of insulin resistance: prospective study in a general population. Hypertension 2011, 58:1043-1048.
    • (2011) Hypertension , vol.58 , pp. 1043-1048
    • Kumagai, E.1    Adachi, H.2    Jacobs, D.R.3    Hirai, Y.4    Enomoto, M.5    Fukami, A.6
  • 80
    • 33845358123 scopus 로고    scopus 로고
    • Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study
    • Giacchetti G., Ronconi V., Turchi F., Agostinelli L., Mantero F., Rilli S., et al. Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study. J Hypertens 2007, 25:177-186.
    • (2007) J Hypertens , vol.25 , pp. 177-186
    • Giacchetti, G.1    Ronconi, V.2    Turchi, F.3    Agostinelli, L.4    Mantero, F.5    Rilli, S.6
  • 83
    • 50349092814 scopus 로고    scopus 로고
    • Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat
    • Lastra G., Whaley-Connell A., Manrique C., Habibi J., Gutweiler A.A., Appesh L., et al. Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. Am J Physiol Endocrinol Metab 2008, 295:110-116.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. 110-116
    • Lastra, G.1    Whaley-Connell, A.2    Manrique, C.3    Habibi, J.4    Gutweiler, A.A.5    Appesh, L.6
  • 84
    • 84856226885 scopus 로고    scopus 로고
    • Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor
    • Sherajee S.J., Fujita Y., Rafiq K., Nakano D., Mori H., Masaki T., et al. Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. Arterioscler Thromb Vasc Biol 2012, 32:257-263.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 257-263
    • Sherajee, S.J.1    Fujita, Y.2    Rafiq, K.3    Nakano, D.4    Mori, H.5    Masaki, T.6
  • 85
    • 84862757033 scopus 로고    scopus 로고
    • The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7)
    • Muñoz M.C., Giani J.F., Burghi V., Mayer M.A., Carranza A., Taira C.A., et al. The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7). Regul Pept 2012, 177:1-11.
    • (2012) Regul Pept , vol.177 , pp. 1-11
    • Muñoz, M.C.1    Giani, J.F.2    Burghi, V.3    Mayer, M.A.4    Carranza, A.5    Taira, C.A.6
  • 86
    • 2342525336 scopus 로고    scopus 로고
    • Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice
    • Shiuchi T., Iwai M., Li H.S., Wu L., Min L.J., Li J.M., et al. Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension 2004, 43:1003-1010.
    • (2004) Hypertension , vol.43 , pp. 1003-1010
    • Shiuchi, T.1    Iwai, M.2    Li, H.S.3    Wu, L.4    Min, L.J.5    Li, J.M.6
  • 87
    • 2942635317 scopus 로고    scopus 로고
    • Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    • Julius S., Kjeldsen S.E., Weber M., Brunner H.R., Ekman S., Hansson L., et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004, 363:2022-2031.
    • (2004) Lancet , vol.363 , pp. 2022-2031
    • Julius, S.1    Kjeldsen, S.E.2    Weber, M.3    Brunner, H.R.4    Ekman, S.5    Hansson, L.6
  • 88
    • 77951453096 scopus 로고    scopus 로고
    • Effect of valsartan on the incidence of diabetes and cardiovascular events
    • NAVIGATOR Study Group
    • McMurray J.J., Holman R.R., Haffner S.M., Bethel M.A., Holzhauer B., et al. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med 2010, 362:1477-1490. NAVIGATOR Study Group.
    • (2010) N Engl J Med , vol.362 , pp. 1477-1490
    • McMurray, J.J.1    Holman, R.R.2    Haffner, S.M.3    Bethel, M.A.4    Holzhauer, B.5
  • 89
    • 84884901103 scopus 로고    scopus 로고
    • Effects of renin-angiotensin system blockade on the islet morphology and function in rats with long-term high-fat diet
    • 10.1007/s00592-010-0210-8. Epub ahead of print
    • Yuan L., Li X., Li J., Li H.L., Cheng S.S. Effects of renin-angiotensin system blockade on the islet morphology and function in rats with long-term high-fat diet. Acta Diabetol 2010 Jul 14, 10.1007/s00592-010-0210-8. Epub ahead of print.
    • (2010) Acta Diabetol
    • Yuan, L.1    Li, X.2    Li, J.3    Li, H.L.4    Cheng, S.S.5
  • 90
    • 77149139835 scopus 로고    scopus 로고
    • Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice
    • Cole B.K., Keller S.R., Wu R., Carter J.D., Nadler J.L., Nunemaker C.S. Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice. Hypertension 2010, 55:715-721.
    • (2010) Hypertension , vol.55 , pp. 715-721
    • Cole, B.K.1    Keller, S.R.2    Wu, R.3    Carter, J.D.4    Nadler, J.L.5    Nunemaker, C.S.6
  • 91
    • 77954386779 scopus 로고    scopus 로고
    • Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-A(y) mice
    • Iwai M., Kanno H., Tomono Y., Inaba S., Senba I., Furuno M., et al. Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-A(y) mice. J Hypertens 2010, 28:1471-1481.
    • (2010) J Hypertens , vol.28 , pp. 1471-1481
    • Iwai, M.1    Kanno, H.2    Tomono, Y.3    Inaba, S.4    Senba, I.5    Furuno, M.6
  • 92
    • 79956188610 scopus 로고    scopus 로고
    • Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial
    • van der Zijl N.J., Moors C.C., Goossens G.H., Hermans M.M., Blaak E.E., Diamant M. Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial. Diabetes Care 2011, 34:845-851.
    • (2011) Diabetes Care , vol.34 , pp. 845-851
    • van der Zijl, N.J.1    Moors, C.C.2    Goossens, G.H.3    Hermans, M.M.4    Blaak, E.E.5    Diamant, M.6
  • 93
    • 84861096120 scopus 로고    scopus 로고
    • Lipid nephrotoxicity: new concept for an old disease
    • Gyebi L., Soltani Z., Reisin E. Lipid nephrotoxicity: new concept for an old disease. Curr Hypertens Rep 2012, 14:177-181.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 177-181
    • Gyebi, L.1    Soltani, Z.2    Reisin, E.3
  • 94
    • 0035166933 scopus 로고    scopus 로고
    • Effect of lipid reduction on the progression of renal disease: a meta-analysis
    • Fried L.F., Orchard T.J., Kasiske B.L. Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 2001, 59:260-269.
    • (2001) Kidney Int , vol.59 , pp. 260-269
    • Fried, L.F.1    Orchard, T.J.2    Kasiske, B.L.3
  • 95
    • 6044267993 scopus 로고    scopus 로고
    • Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats
    • Ran J., Hirano T., Adachi M. Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats. Am J Physiol Endocrinol Metab 2004, 287:955-961.
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , pp. 955-961
    • Ran, J.1    Hirano, T.2    Adachi, M.3
  • 96
    • 23044505229 scopus 로고    scopus 로고
    • Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor
    • Kouyama R., Suganami T., Nishida J., Tanaka M., Toyoda T., Kiso M., et al. Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Endocrinology 2005, 146:3481-3489.
    • (2005) Endocrinology , vol.146 , pp. 3481-3489
    • Kouyama, R.1    Suganami, T.2    Nishida, J.3    Tanaka, M.4    Toyoda, T.5    Kiso, M.6
  • 97
    • 34247881925 scopus 로고    scopus 로고
    • Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes
    • Mori Y., Itoh Y., Tajima N. Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes. Adv Ther 2007, 24:146-153.
    • (2007) Adv Ther , vol.24 , pp. 146-153
    • Mori, Y.1    Itoh, Y.2    Tajima, N.3
  • 98
    • 40149085377 scopus 로고    scopus 로고
    • Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats
    • Kamari Y., Harari A., Shaish A., Peleg E., Sharabi Y., Harats D., et al. Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats. Hypertens Res 2008, 31:135-140.
    • (2008) Hypertens Res , vol.31 , pp. 135-140
    • Kamari, Y.1    Harari, A.2    Shaish, A.3    Peleg, E.4    Sharabi, Y.5    Harats, D.6
  • 99
    • 77955477023 scopus 로고    scopus 로고
    • Telmisartan ameliorates hyperglycemia and metabolic profile in nonobese Cohen-Rosenthal diabetic hypertensive rats via peroxisome proliferator activator receptor-gamma activation
    • Younis F., Stern N., Limor R., Oron Y., Zangen S., Rosenthal T. Telmisartan ameliorates hyperglycemia and metabolic profile in nonobese Cohen-Rosenthal diabetic hypertensive rats via peroxisome proliferator activator receptor-gamma activation. Metabolism 2010, 59:1200-1209.
    • (2010) Metabolism , vol.59 , pp. 1200-1209
    • Younis, F.1    Stern, N.2    Limor, R.3    Oron, Y.4    Zangen, S.5    Rosenthal, T.6
  • 100
    • 43449087025 scopus 로고    scopus 로고
    • Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway
    • Sugimoto K., Kazdová L., Qi N.R., Hyakukoku M., Kren V., Simáková M., et al. Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway. J Hypertens 2008, 26:1209-1215.
    • (2008) J Hypertens , vol.26 , pp. 1209-1215
    • Sugimoto, K.1    Kazdová, L.2    Qi, N.R.3    Hyakukoku, M.4    Kren, V.5    Simáková, M.6
  • 101
    • 0033997144 scopus 로고    scopus 로고
    • Studies of renal injury III: lipid-induced nephropathy in type II diabetes
    • Dominguez J.H., Tang N., Xu W., Evan A.P., Siakotos A.N., Agarwal R., et al. Studies of renal injury III: lipid-induced nephropathy in type II diabetes. Kidney Int 2000, 57:92-104.
    • (2000) Kidney Int , vol.57 , pp. 92-104
    • Dominguez, J.H.1    Tang, N.2    Xu, W.3    Evan, A.P.4    Siakotos, A.N.5    Agarwal, R.6
  • 103
    • 34548395147 scopus 로고    scopus 로고
    • Microcirculation: nexus of comorbidities in diabetes
    • Temm C., Dominguez J.H. Microcirculation: nexus of comorbidities in diabetes. Am J Physiol Renal Physiol 2007, 293:486-493.
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. 486-493
    • Temm, C.1    Dominguez, J.H.2
  • 104
    • 34548645095 scopus 로고    scopus 로고
    • Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy
    • Dominguez J., Wu P., Packer C.S., Temm C., Kelly K.J. Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy. Am J Physiol Renal Physiol 2007, 293:670-679.
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. 670-679
    • Dominguez, J.1    Wu, P.2    Packer, C.S.3    Temm, C.4    Kelly, K.J.5
  • 106
    • 79960565983 scopus 로고    scopus 로고
    • Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs
    • Liu Y., Wang Z.B., Yin W.D., Li Q.K., Cai M.B., Yu J., et al. Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs. Lipids Health Dis 2011, 10:117.
    • (2011) Lipids Health Dis , vol.10 , pp. 117
    • Liu, Y.1    Wang, Z.B.2    Yin, W.D.3    Li, Q.K.4    Cai, M.B.5    Yu, J.6
  • 107
    • 12144269145 scopus 로고    scopus 로고
    • The statins-therapeutic diversity in renal disease?
    • Mason J.C. The statins-therapeutic diversity in renal disease?. Curr Opin Nephrol Hypertens 2005, 14:17-24.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 17-24
    • Mason, J.C.1
  • 108
    • 78349285889 scopus 로고    scopus 로고
    • Adding a statin to a combination of ACE inhibitor and ARB normalizes proteinuria in experimental diabetes, which translates into full renoprotection
    • Zoja C., Corna D., Gagliardini E., Conti S., Arnaboldi L., Benigni A., et al. Adding a statin to a combination of ACE inhibitor and ARB normalizes proteinuria in experimental diabetes, which translates into full renoprotection. Am J Physiol Renal Physiol 2010, 299:1203-1211.
    • (2010) Am J Physiol Renal Physiol , vol.299 , pp. 1203-1211
    • Zoja, C.1    Corna, D.2    Gagliardini, E.3    Conti, S.4    Arnaboldi, L.5    Benigni, A.6
  • 109
    • 11844258767 scopus 로고    scopus 로고
    • Lipid oxidative stress and the anti-inflammatory properties of statins and ACE inhibitors
    • Cattaneo D., Remuzzi G. Lipid oxidative stress and the anti-inflammatory properties of statins and ACE inhibitors. J Ren Nutr 2005, 15:71-76.
    • (2005) J Ren Nutr , vol.15 , pp. 71-76
    • Cattaneo, D.1    Remuzzi, G.2
  • 110
    • 27444436719 scopus 로고    scopus 로고
    • Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II
    • Saito K., Ishizaka N., Hara M., Matsuzaki G., Sata M., Mori I., et al. Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II. Hypertension 2005, 46:1180-1185.
    • (2005) Hypertension , vol.46 , pp. 1180-1185
    • Saito, K.1    Ishizaka, N.2    Hara, M.3    Matsuzaki, G.4    Sata, M.5    Mori, I.6
  • 111
    • 0023204243 scopus 로고
    • Incidence and precursors of hypertension in young adults: the Framingham Offspring Study
    • Garrison R.J., Kannel W.B., Stokes J., Castelli W.P. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med 1987, 16:235-251.
    • (1987) Prev Med , vol.16 , pp. 235-251
    • Garrison, R.J.1    Kannel, W.B.2    Stokes, J.3    Castelli, W.P.4
  • 113
    • 79952373965 scopus 로고    scopus 로고
    • Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes
    • Haller H., Ito S., Izzo J.L., Januszewicz A., Katayama S., Menne J., et al. Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. N Engl J Med 2011, 364:907-917.
    • (2011) N Engl J Med , vol.364 , pp. 907-917
    • Haller, H.1    Ito, S.2    Izzo, J.L.3    Januszewicz, A.4    Katayama, S.5    Menne, J.6
  • 114
    • 0035922444 scopus 로고    scopus 로고
    • Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Parving H.H., Lehnert H., Bröchner-Mortensen J., Gomis R., Andersen S., Arner P. Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001, 345:870-878.
    • (2001) N Engl J Med , vol.345 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Bröchner-Mortensen, J.3    Gomis, R.4    Andersen, S.5    Arner, P.6
  • 115
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis E.J., Hunsicker L.G., Clarke W.R., Berl T., Pohl M.A., Lewis J.B., et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001, 345:851-860.
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3    Berl, T.4    Pohl, M.A.5    Lewis, J.B.6
  • 116
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner B.M., Cooper M.E., de Zeeuw D., Keane W.F., Mitch W.E., Parving H.H., et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001, 345:861-869.
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3    Keane, W.F.4    Mitch, W.E.5    Parving, H.H.6
  • 117
    • 44849114597 scopus 로고    scopus 로고
    • Aliskiren combined with losartan in type 2 diabetes and nephropathy
    • AVOID Study Investigators
    • Parving H.H., Persson F., Lewis J.B., Lewis E.J., Hollenberg N.K. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med 2008, 358:2433-2446. AVOID Study Investigators.
    • (2008) N Engl J Med , vol.358 , pp. 2433-2446
    • Parving, H.H.1    Persson, F.2    Lewis, J.B.3    Lewis, E.J.4    Hollenberg, N.K.5
  • 118
    • 82455162519 scopus 로고    scopus 로고
    • Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study
    • Imai E., Chan J.C., Ito S., Yamasaki T., Kobayashi F., Haneda M., et al. Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study. Diabetologia 2011, 54:2978-2986.
    • (2011) Diabetologia , vol.54 , pp. 2978-2986
    • Imai, E.1    Chan, J.C.2    Ito, S.3    Yamasaki, T.4    Kobayashi, F.5    Haneda, M.6
  • 119
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
    • Mann J.F., Schmieder R.E., McQueen M., Dyal L., Schumacher H., Pogue J., et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008, 372:547-553.
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1    Schmieder, R.E.2    McQueen, M.3    Dyal, L.4    Schumacher, H.5    Pogue, J.6
  • 121
    • 84867632500 scopus 로고    scopus 로고
    • Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions
    • Angeli F., Reboldi G., Mazzotta G., Poltronieri C., Garofoli M., Ramundo E., et al. Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions. Curr Drug Saf 2012, 7:76-85.
    • (2012) Curr Drug Saf , vol.7 , pp. 76-85
    • Angeli, F.1    Reboldi, G.2    Mazzotta, G.3    Poltronieri, C.4    Garofoli, M.5    Ramundo, E.6


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