Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Liu, Yi ^a,b   Wang, Zong Bao ^a   Yin, Wei Dong ^a   Li, Qin Kai ^a   Cai, Man Bo ^a   Yu, Jian ^a   Li, Hong Guang ^a,b   Zhang, Chi ^a   Zu, Xiu Hong ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b SHAOGUAN UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Lipid accumulation; Lipoprotein lipase; Lipoprotein lipase activator; Swine, Miniature

Indexed keywords

ALBUMIN; CHOLESTEROL; IBROLIPIM; INSULIN; LIPOPROTEIN LIPASE; MESSENGER RNA; TRIACYLGLYCEROL; 4-DIETHOXYPHOSPHORYLMETHYL-N-(4-BROMO-2-CYANOPHENYL)BENZAMIDE; ANTILIPEMIC AGENT; BENZAMIDE DERIVATIVE; CREATININE; LIPID; ORGANOPHOSPHORUS COMPOUND; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; KIDNEY; KIDNEY FUNCTION; KIDNEY PARENCHYMA; LIPID BLOOD LEVEL; LIPID DIET; MALE; MICROALBUMINURIA; MINIPIG; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ALBUMINURIA; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DIABETIC NEPHROPATHY; DRUG SCREENING; ENZYME ASSAY; EXPERIMENTAL DIABETES MELLITUS; FAT INTAKE; GENE EXPRESSION; GENETICS; LIPID METABOLISM; METABOLISM; ORGAN SIZE; PATHOLOGY; SWINE; URINE;

SUIDAE;

ALBUMINURIA; ANIMALS; BENZAMIDES; BLOOD GLUCOSE; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DIETARY FATS; DRUG EVALUATION, PRECLINICAL; ENZYME ASSAYS; GENE EXPRESSION; HYPOLIPIDEMIC AGENTS; INSULIN; KIDNEY; LIPID METABOLISM; LIPIDS; LIPOPROTEIN LIPASE; MALE; ORGAN SIZE; ORGANOPHOSPHORUS COMPOUNDS; SUCROSE; SWINE; SWINE, MINIATURE;

EID: 79960565983     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-117     Document Type: Article

References (45)

1. Lipids in progression of renal disease. Oda H Keane WF, Kidney Int Suppl 1997 62 36 S38 9350676
2. The role of lipids in renal disease: future challenges. Keane WF, Kidney Int Suppl 2000 75 27 S31 10828758
3. db/db mice with type 2 diabetes. Wang Z Jiang T, Li J Proctor G, McManaman JL Lucia S, Chua S Levi M, Diabetes 2005 54 2328 2335 10.2337/diabetes.54.8.2328 16046298 (Pubitemid 41134259)
4. Renal injury of diet-induced hypercholesterolemia in rats. Kasiske BL O'Donnell MP Schmitz PG Kim Y, Keane WF,, Kidney Int 1990 37 880 891 10.1038/ki.1990.62 2313977 (Pubitemid 20089220)
5. Early glomerular changes in rats with dietary-induced hypercholesterolemia. Guijarro C Kasiske BL, Kim Y O'Donnell MP, Lee HS Keane WF, Am J Kidney Dis 1995 26 152 161 10.1016/0272-6386(95)90169-8 7611247
6. Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. Jiang T Wang Z Proctor G Moskowitz S, Liebman SE Rogers T, Lucia MS Li J, Levi M,, J Biol Chem 2005 280 32317 32325 10.1074/jbc.M500801200 16046411 (Pubitemid 41361841)
7. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1. Li Q Yin W, Cai M Liu Y, Hou H Shen Q, Zhang C Xiao J, Hu X Wu Q, Funaki M Nakaya Y, J Endocrinol 2010 204 47 56 10.1677/JOE-09-0278 19815588
8. Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/ high-sucrose/ high-cholesterol diet. Liu Y Wang Z, Yin W Li Q, Cai M Zhang C, Xiao J Hou H, Li H Zu X, Exp Anim 2007 56 11 20 10.1538/expanim.56.11 17283886 (Pubitemid 46358577)
9. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. Goldberg IJ, J Lipid Res 1996 37 693 707 8732771 (Pubitemid 26140808)
10. Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Preiss-Landl K Zimmermann R, Hämmerle G Zechner R, Curr Opin Lipidol 2002 13 471 481 10.1097/00041433-200210000-00002 12352010 (Pubitemid 35231926)
11. Lipoprotein lipase is expressed by glomerular mesangial cells. Irvine SA Martin J, Hughes TR Ramji DP, Int J Biochem Cell Biol 2006 38 12 16 10.1016/j.biocel.2005.07.008 16140560 (Pubitemid 41540712)
12. Lipoprotein lipase in the kidney: activity varies widely among animal species. Ruge T Neuger L Sukonina V Wu G, Barath S Gupta J, Frankel B Christophersen B, Nordstoga K Olivecrona T, Olivecrona G,, Am J Physiol Renal Physiol 2004 287 1131 F1139 10.1152/ajprenal.00089.2004 15292043
13. Lipoprotein-stimulated mesangial cell proliferation and gene expression are regulated by lipoprotein lipase. Stevenson FT Shearer GC Atkinson DN,, Kidney Int 2001 59 2062 2068 11380807 (Pubitemid 32467597)
14. Very-low-density lipoprotein-induced triglyceride accumulation in human mesangial cells is mainly mediated by lipoprotein lipase. Li J Li H, Wen YB Li XW, Nephron Physiol 2008 110 1 p10 10.1159/000151272 18698144
15. Lipoprotein metabolism in the nephrotic syndrome. Marsh JB, Front Biosci 2002 7 326 e338 10.2741/marsh 12133820
16. Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomerulosclerosis. Sato T Liang K Vaziri ND,, Kidney Int 2002 61 157 162 10.1046/j.1523-1755.2002.00104.x 11786096 (Pubitemid 34075142)
17. Gene expression of lipoprotein lipase in experimental nephrosis. Liang K Vaziri ND, J Lab Clin Med 1997 130 387 394 10.1016/S0022-2143(97)90038-X 9358077 (Pubitemid 27498664)
18. Down-regulation of tissue lipoprotein lipase expression in experimental chronic renal failure. Vaziri ND Liang K, Kidney Int 1996 50 1928 1935 10.1038/ki.1996.515 8943476 (Pubitemid 26417536)
19. The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. Tsutsumi K Inoue Y, Shima A Iwasaki K, Kawamura M Murase T, J Clin Invest 1993 92 411 417 10.1172/JCI116582 8326009 (Pubitemid 23209023)
20. Correction of hypertriglyceridemia with low high-density lipoprotein cholesterol by the novel compound NO-1886, a lipoprotein lipase-promoting agent, in STZ-induced diabetic rats. Tsutsumi K Inoue Y, Shima A Murase T, Diabetes 1995 44 414 417 10.2337/diabetes.44.4.414 7698509
21. Lipoprotein lipase activator NO-1886. Yin WD Tsutsumi K, Cardiovasc Drug Rev 2003 21 133 142 12847564 (Pubitemid 36935491)
22. The lipoprotein lipase activator, NO-1886, suppresses fat accumulation and insulin resistance in rats fed a high-fat diet. Kusunoki M Hara T, Tsutsumi K Nakamura T, Miyata T Sakakibara F, Sakamoto S Ogawa H, Nakaya Y Storlien LH, Diabetologia 2000 43 875 880 10.1007/s001250051464 10952460 (Pubitemid 30463167)
23. NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine. Yin W Liao D Kusunoki M Xi S, Tsutsumi K Wang Z, Lian X Koike T, Fan J Yang Y, Tang C,, J Endocrinol 2004 180 399 408 10.1677/joe.0.1800399 15012594 (Pubitemid 38443392)
24. Effect of the lipoprotein lipase activator NO-1886 on adriamycin-induced nephrotic syndrome in rats. Nakayama K Hara T, Kusunoki M Tsutsumi K, Minami A Okada K, Sakamoto S Ohnaka M, Miyata T Nakamura T, Aoki T Fukatsu A, Nakaya Y Kakumu S, Metabolism 2000 49 588 593 10.1016/S0026-0495(00)80032-3 10831167 (Pubitemid 30305255)
25. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Bonora E Targher G, Alberiche M Bonadonna RC, Saggiani F Zenere MB, Monauni T Muggeo M, Diabetes Care 2000 23 57 63 10.2337/diacare.23.1.57 10857969 (Pubitemid 30022895)
26. A selective decline of postheparin plasma hepatic triglyceride lipase in hypothyroid rats. Murase T Uchimura H, Metabolism 1980 29 797 801 10.1016/0026-0495(80)90207-3 7402081 (Pubitemid 10035093)
27. Single-void urine samples can be used to estimate quantitative microalbuminuria. Nathan DM Rosenbaum C Protasowicki VD,, Diabetes Care 1987 10 414 418 10.2337/diacare.10.4.414 3622198 (Pubitemid 17133602)
28. A rapid method of total lipid extraction and purification. Bligh EG Dyer WJ, Can J Biochem Physiol 1959 37 911 917 10.1139/o59-099 13671378
29. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Amin KA Kamel HH Abd Eltawab MA,, Lipids Health Dis 2011 10 6 10.1186/1476-511X-10-6 21235803
30. Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression. Kirchgessner TG LeBoeuf RC Langner CA Zollman S, Chang CH Taylor BA, Schotz MC Gordon JI, Lusis AJ,, J Biol Chem 1989 264 1473 1482 2563260 (Pubitemid 19050983)
31. A mutation in the lipoprotein lipase gene associated with hyperlipoproteinemia type I in mink: studies on lipid and lipase levels in heterozygotes. Lindberg A Nordstoga K, Christophersen B Savonen R, van Tol A Olivecrona G, Int J Mol Med 1998 1 529 538 9852258
32. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats. Lim WY Chia YY, Liong SY Ton SH, Kadir KA Husain SN, Lipids Health Dis 2009 8 31 10.1186/1476-511X-8-31 19638239
33. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Eu CH Lim WY, Ton SH bin Abdul Kadir K, Lipids Health Dis 2010 9 81 10.1186/1476-511X-9-81 20670429
34. Lipoprotein lipase: cellular origin and functional distribution. Camps L Reina M Llobera M Vilará S, Olivecrona T,, Am J Physiol 1990 258 673 C681 2185641
35. Lipoprotein lipase in plasma after an oral fat load: relation to free fatty acids. Karpe F Olivecrona T, Walldius G Hamsten A, J Lipid Res 1992 33 975 984 1431589
36. Nutritional regulation of lipoprotein lipase in guinea pig tissues. Semb H Olivecrona T, Biochim Biophys Acta 1986 876 249 255 3955064 (Pubitemid 16014858)
37. Nutritional regulation of lipoprotein lipase in mice. Ruge T Wu G, Olivecrona T Olivecrona G, Int J Biochem Cell Biol 2004 36 320 329 10.1016/S1357-2725(03)00256-5 14643896 (Pubitemid 37487766)
38. Apolipoprotein CII and lipoprotein lipase in human nephrotic syndrome. Kashyap ML Srivastava LS Hynd BA Brady D, Perisutti G Glueck CJ, Gartside PS,, Atherosclerosis 1980 35 29 40 10.1016/0021-9150(80)90025-8 7370086 (Pubitemid 10201900)
39. Changes in biological activity and immunoreactive mass of lipoprotein lipase in congenital nephrosis: relationship to hypertriglyceridaemia. Antikainen M Holmberg C Olivecrona T Bengtsson-Olivecrona G, Labeur C Rosseneu M, Taskinen MR,, Eur J Clin Invest 1993 23 368 374 10.1111/j.1365-2362.1993. tb02038.x 8344337 (Pubitemid 23168560)
40. Experimental nephrotic syndrome: removal and tissue distribution of chylomicrons and very-low-density lipoproteins of normal and nephrotic origin. Levy E Ziv E, Bar-On H Shafrir E, Biochim Biophys Acta 1990 1043 259 266 2322571 (Pubitemid 20103660)
41. Secondary hyperparathyroidism downregulates lipoprotein lipase expression in chronic renal failure. Vaziri ND Wang XQ Liang K,, Am J Physiol 1997 273 925 F930 9435681
42. Lipoprotein lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent of scavenger receptor BI. Rinninger F Brundert M, Brosch I Donarski N, Budzinski RM Greten H, J Lipid Res 2001 42 1740 1751 11714843 (Pubitemid 33116705)
43. Effect of losartan on insulin plasma concentrations and LPL activity in adipose tissue of hypertensive rats. Saranteas T Lolis E, Mourouzis C Potamianou A, Tesseromatis C Varonos D, Horm Metab Res 2003 35 164 168 12734777 (Pubitemid 36577858)
44. NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. Zhang C Yin W, Liao D Huang L, Tang C Tsutsumi K, Wang Z Liu Y, Li Q Hou H, Cai M Xiao J, J Lipid Res 2006 47 2055 2063 10.1194/jlr.M600226-JLR200 16807312 (Pubitemid 44401994)
45. Discovery of novel mesangial cell proliferation inhibitors using a three-dimensional database searching method. Kurogi Y Miyata K, Okamura T Hashimoto K, Tsutsumi K Nasu M, Moriyasu M, J Med Chem 2001 44 2304 2307 10.1021/jm010060v 11428924 (Pubitemid 32867399)