메뉴 건너뛰기




Volumn 21, Issue 2, 2012, Pages 137-141

The interaction between prorenin, renin and the (pro)renin receptor: Time to rethink the role in hypertension

Author keywords

prorenin; prorenin receptor; renin; transgenic

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANGIOTENSIN II; PRORENIN; PRORENIN RECEPTOR; RENIN;

EID: 84857060472     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3283500927     Document Type: Review
Times cited : (10)

References (22)
  • 1
  • 2
    • 0021889169 scopus 로고
    • Increased plasma inactive renin in diabetes mellitus. A marker of macrovascular complications
    • Luetscher JA, Kraemer FB, Wilson DM, et al. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N Engl J Med 1985; 312:1412-1417. (Pubitemid 15083658)
    • (1985) New England Journal of Medicine , vol.312 , Issue.22 , pp. 1412-1417
    • Luetscher, J.A.1    Kraemer, F.B.2    Wilson, D.M.3
  • 7
    • 73349141162 scopus 로고    scopus 로고
    • Does prorenin exert angiotensin-independent effects in vivo?
    • Danser AH. Does prorenin exert angiotensin-independent effects in vivo? Hypertension 2009; 54:1218-1220.
    • (2009) Hypertension , vol.54 , pp. 1218-1220
    • Danser, A.H.1
  • 8
    • 80053129927 scopus 로고    scopus 로고
    • HRP and prorenin: Focus on the prorenin and renin receptor and vacuolar H+-ATPase
    • Lu X, Danser AH, Meima ME. HRP and prorenin: Focus on the prorenin and renin receptor and vacuolar H+-ATPase. Front Biosci (Schol.Ed) 2011; 3:1205-1215.
    • (2011) Front Biosci (Schol.Ed) , vol.3 , pp. 1205-1215
    • Lu, X.1    Danser, A.H.2    Meima, M.E.3
  • 9
    • 77954756914 scopus 로고    scopus 로고
    • Physiology of the prorenin and renin receptor: Wnt of change?
    • Sihn G, Rousselle A, Vilianovitch L, et al. Physiology of the prorenin and renin receptor: Wnt of change? Kidney Int 2010; 78:246-256.
    • (2010) Kidney Int , vol.78 , pp. 246-256
    • Sihn, G.1    Rousselle, A.2    Vilianovitch, L.3
  • 10
    • 77951499583 scopus 로고    scopus 로고
    • Prorenin, renin, and their receptor: Moving targets
    • Reudelhuber TL. Prorenin, renin, and their receptor: Moving targets. Hypertension 2010; 55:1071-1074.
    • (2010) Hypertension , vol.55 , pp. 1071-1074
    • Reudelhuber, T.L.1
  • 11
    • 68549111147 scopus 로고    scopus 로고
    • The prorenin and renin receptor: Site-specific and functional linkage to the vacuolar H+-ATPase in the kidney
    • Advani A, Kelly DJ, Cox AJ, et al. The prorenin and renin receptor: Site-specific and functional linkage to the vacuolar H+-ATPase in the kidney. Hypertension 2009; 54:261-269.
    • (2009) Hypertension , vol.54 , pp. 261-269
    • Advani, A.1    Kelly, D.J.2    Cox, A.J.3
  • 12
    • 79955604483 scopus 로고    scopus 로고
    • The cardiac prorenin and renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy
    • This study showed that (P)RR colocalized in the normal and failing heart with components of the vacuolar ATPase. An earlier study by the same group came to similar conclusions for the kidney
    • Connelly KA, Advani A, Kim S, et al. The cardiac prorenin and renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy. J Hypertens 2011; 29:1175-1184. This study showed that (P)RR colocalized in the normal and failing heart with components of the vacuolar ATPase. An earlier study by the same group came to similar conclusions for the kidney.
    • (2011) J Hypertens , vol.29 , pp. 1175-1184
    • Connelly, K.A.1    Advani, A.2    Kim, S.3
  • 13
    • 75649120756 scopus 로고    scopus 로고
    • Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
    • This was a truly landmark finding that explained why it was impossible to engineer a whole-body 'knock out' of (P)RR in mice. It also was the first study to clearly demonstrate a role for (P)RR that was independent of its ability to bind prorenin or renin
    • Cruciat CM, Ohkawara B, Acebron SP, et al. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 2010; 327:459-463. This was a truly landmark finding that explained why it was impossible to engineer a whole-body 'knock out' of (P)RR in mice. It also was the first study to clearly demonstrate a role for (P)RR that was independent of its ability to bind prorenin or renin.
    • (2010) Science , vol.327 , pp. 459-463
    • Cruciat, C.M.1    Ohkawara, B.2    Acebron, S.P.3
  • 14
    • 77954762963 scopus 로고    scopus 로고
    • The prorenin and renin receptor/ ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    • These authors used a targeted 'knock out' of (P)RR in the heart which resulted in wholesale cardiomyocyte death and heart failure. This was the first study to show that even terminally differentiated cells require (P)RR for health and survival
    • Kinouchi K, Ichihara A, Sano M, et al. The prorenin and renin receptor/ ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res 2010; 107:30-34. These authors used a targeted 'knock out' of (P)RR in the heart which resulted in wholesale cardiomyocyte death and heart failure. This was the first study to show that even terminally differentiated cells require (P)RR for health and survival.
    • (2010) Circ Res , vol.107 , pp. 30-34
    • Kinouchi, K.1    Ichihara, A.2    Sano, M.3
  • 15
    • 82655181486 scopus 로고    scopus 로고
    • Prorenin receptor is essential for normal podocyte structure and function
    • This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, renal failure and premature death due to deacidification of intracellular vesicles
    • Oshima Y, Kinouchi K, Ichihara A, et al. Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol 2011; 22:2203-2212. This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, renal failure and premature death due to deacidification of intracellular vesicles.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 2203-2212
    • Oshima, Y.1    Kinouchi, K.2    Ichihara, A.3
  • 16
    • 82655181484 scopus 로고    scopus 로고
    • Prorenin receptor is essential for podocyte autophagy and survival
    • This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, nephrotic syndrome and premature death due to deacidification of intracellular vesicles
    • Riediger F, Quack I, Qadri F, et al. Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 2011; 22:2193-2202. This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, nephrotic syndrome and premature death due to deacidification of intracellular vesicles.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 2193-2202
    • Riediger, F.1    Quack, I.2    Qadri, F.3
  • 18
    • 67049100691 scopus 로고    scopus 로고
    • Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies
    • Mercure C, Prescott G, Lacombe MJ, et al. Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies. Hypertension 2009; 53:1062-1069.
    • (2009) Hypertension , vol.53 , pp. 1062-1069
    • Mercure, C.1    Prescott, G.2    Lacombe, M.J.3
  • 19
    • 73349109829 scopus 로고    scopus 로고
    • Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver
    • Campbell DJ, Karam H, Menard J, et al. Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver. Hypertension 2009; 54:1248-1253.
    • (2009) Hypertension , vol.54 , pp. 1248-1253
    • Campbell, D.J.1    Karam, H.2    Menard, J.3
  • 21
    • 15144347939 scopus 로고    scopus 로고
    • Determinants of interindividual variation of renin and prorenin concentrations: Evidence for a sexual dimorphism of (pro)renin levels in humans
    • DOI 10.1097/00004872-199816060-00017
    • Danser AH, Derkx FH, Schalekamp MA, et al. Determinants of interindividual variation of renin and prorenin concentrations: Evidence for a sexual dimorphism of prorenin and renin levels in humans. J Hypertens 1998; 16:853-862. (Pubitemid 28247969)
    • (1998) Journal of Hypertension , vol.16 , Issue.6 , pp. 853-862
    • Jan Danser, A.H.1    Derkx, F.H.M.2    Schalekamp, M.A.D.H.3    Hense, H.-W.4    Riegger, G.A.J.5    Schunkert, H.6
  • 22
    • 83155180323 scopus 로고    scopus 로고
    • Renin-And prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human prorenin and renin receptor: Does prorenin and renin-prorenin and renin receptor interaction actually occur?
    • This study carefully analyzes the concentrations of prorenin and renin required for various types of signaling through (P)RR. These observations have important implications for the sites wherein these interactions might be physiologically important
    • Batenburg WW, Lu X, Leijten F, et al. Renin-And prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human prorenin and renin receptor: Does prorenin and renin-prorenin and renin receptor interaction actually occur? Hypertension 2011; 58:1111-1119. This study carefully analyzes the concentrations of prorenin and renin required for various types of signaling through (P)RR. These observations have important implications for the sites wherein these interactions might be physiologically important.
    • (2011) Hypertension , vol.58 , pp. 1111-1119
    • Batenburg, W.W.1    Lu, X.2    Leijten, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.