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1
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0036266596
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Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
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DOI 10.1172/JCI200214276
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Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109:1417-1427. (Pubitemid 34596167)
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(2002)
Journal of Clinical Investigation
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Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.-D.6
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2
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0021889169
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Increased plasma inactive renin in diabetes mellitus. A marker of macrovascular complications
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Luetscher JA, Kraemer FB, Wilson DM, et al. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N Engl J Med 1985; 312:1412-1417. (Pubitemid 15083658)
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(1985)
New England Journal of Medicine
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Luetscher, J.A.1
Kraemer, F.B.2
Wilson, D.M.3
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3
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9644283069
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Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
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DOI 10.1172/JCI200421398
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Ichihara A, Hayashi M, Kaneshiro Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin. J Clin Invest 2004; 114:1128-1135. (Pubitemid 39578702)
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(2004)
Journal of Clinical Investigation
, vol.114
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Ichihara, A.1
Hayashi, M.2
Kaneshiro, Y.3
Suzuki, F.4
Nakagawa, T.5
Tada, Y.6
Koura, Y.7
Nishiyama, A.8
Okada, H.9
Uddin, M.N.10
Nabi, A.H.M.N.11
Ishida, Y.12
Inagami, T.13
Saruta, T.14
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4
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33646160993
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Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
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DOI 10.1161/01.HYP.0000215838.48170.0b, PII 0000426820060500000019
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Ichihara A, Kaneshiro Y, Takemitsu T, et al. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 2006; 47:894-900. (Pubitemid 44297561)
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(2006)
Hypertension
, vol.47
, Issue.5
, pp. 894-900
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Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Suzuki, F.5
Nakagawa, T.6
Nishiyama, A.7
Inagami, T.8
Hayashi, M.9
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5
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33748044643
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Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage
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DOI 10.1681/ASN.2005121278
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Ichihara A, Kaneshiro Y, Takemitsu T, et al. Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 2006; 17:2495-2503. (Pubitemid 44300965)
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(2006)
Journal of the American Society of Nephrology
, vol.17
, Issue.9
, pp. 2495-2503
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Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Nakagawa, T.5
Nishiyama, A.6
Kawachi, H.7
Shimizu, F.8
Inagami, T.9
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6
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33846902147
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Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
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DOI 10.1167/iovs.06-0534
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Satofuka S, Ichihara A, Nagai N, et al. Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization. Invest Ophthalmol Vis Sci 2007; 48:422-429. (Pubitemid 47251433)
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(2007)
Investigative Ophthalmology and Visual Science
, vol.48
, Issue.1
, pp. 422-429
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Satofuka, S.1
Ichihara, A.2
Nagai, N.3
Koto, T.4
Shinoda, H.5
Noda, K.6
Ozawa, Y.7
Inoue, M.8
Tsubota, K.9
Itoh, H.10
Oike, Y.11
Ishida, S.12
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7
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73349141162
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Does prorenin exert angiotensin-independent effects in vivo?
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Danser AH. Does prorenin exert angiotensin-independent effects in vivo? Hypertension 2009; 54:1218-1220.
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(2009)
Hypertension
, vol.54
, pp. 1218-1220
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Danser, A.H.1
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8
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80053129927
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HRP and prorenin: Focus on the prorenin and renin receptor and vacuolar H+-ATPase
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Lu X, Danser AH, Meima ME. HRP and prorenin: Focus on the prorenin and renin receptor and vacuolar H+-ATPase. Front Biosci (Schol.Ed) 2011; 3:1205-1215.
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(2011)
Front Biosci (Schol.Ed)
, vol.3
, pp. 1205-1215
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Lu, X.1
Danser, A.H.2
Meima, M.E.3
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9
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77954756914
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Physiology of the prorenin and renin receptor: Wnt of change?
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Sihn G, Rousselle A, Vilianovitch L, et al. Physiology of the prorenin and renin receptor: Wnt of change? Kidney Int 2010; 78:246-256.
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(2010)
Kidney Int
, vol.78
, pp. 246-256
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Sihn, G.1
Rousselle, A.2
Vilianovitch, L.3
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10
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77951499583
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Prorenin, renin, and their receptor: Moving targets
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Reudelhuber TL. Prorenin, renin, and their receptor: Moving targets. Hypertension 2010; 55:1071-1074.
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(2010)
Hypertension
, vol.55
, pp. 1071-1074
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Reudelhuber, T.L.1
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11
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68549111147
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The prorenin and renin receptor: Site-specific and functional linkage to the vacuolar H+-ATPase in the kidney
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Advani A, Kelly DJ, Cox AJ, et al. The prorenin and renin receptor: Site-specific and functional linkage to the vacuolar H+-ATPase in the kidney. Hypertension 2009; 54:261-269.
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(2009)
Hypertension
, vol.54
, pp. 261-269
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Advani, A.1
Kelly, D.J.2
Cox, A.J.3
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12
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79955604483
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The cardiac prorenin and renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy
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This study showed that (P)RR colocalized in the normal and failing heart with components of the vacuolar ATPase. An earlier study by the same group came to similar conclusions for the kidney
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Connelly KA, Advani A, Kim S, et al. The cardiac prorenin and renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy. J Hypertens 2011; 29:1175-1184. This study showed that (P)RR colocalized in the normal and failing heart with components of the vacuolar ATPase. An earlier study by the same group came to similar conclusions for the kidney.
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(2011)
J Hypertens
, vol.29
, pp. 1175-1184
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Connelly, K.A.1
Advani, A.2
Kim, S.3
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13
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75649120756
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Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
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This was a truly landmark finding that explained why it was impossible to engineer a whole-body 'knock out' of (P)RR in mice. It also was the first study to clearly demonstrate a role for (P)RR that was independent of its ability to bind prorenin or renin
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Cruciat CM, Ohkawara B, Acebron SP, et al. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 2010; 327:459-463. This was a truly landmark finding that explained why it was impossible to engineer a whole-body 'knock out' of (P)RR in mice. It also was the first study to clearly demonstrate a role for (P)RR that was independent of its ability to bind prorenin or renin.
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(2010)
Science
, vol.327
, pp. 459-463
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Cruciat, C.M.1
Ohkawara, B.2
Acebron, S.P.3
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14
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77954762963
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The prorenin and renin receptor/ ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
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These authors used a targeted 'knock out' of (P)RR in the heart which resulted in wholesale cardiomyocyte death and heart failure. This was the first study to show that even terminally differentiated cells require (P)RR for health and survival
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Kinouchi K, Ichihara A, Sano M, et al. The prorenin and renin receptor/ ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res 2010; 107:30-34. These authors used a targeted 'knock out' of (P)RR in the heart which resulted in wholesale cardiomyocyte death and heart failure. This was the first study to show that even terminally differentiated cells require (P)RR for health and survival.
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(2010)
Circ Res
, vol.107
, pp. 30-34
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Kinouchi, K.1
Ichihara, A.2
Sano, M.3
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15
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82655181486
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Prorenin receptor is essential for normal podocyte structure and function
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This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, renal failure and premature death due to deacidification of intracellular vesicles
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Oshima Y, Kinouchi K, Ichihara A, et al. Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol 2011; 22:2203-2212. This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, renal failure and premature death due to deacidification of intracellular vesicles.
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(2011)
J Am Soc Nephrol
, vol.22
, pp. 2203-2212
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Oshima, Y.1
Kinouchi, K.2
Ichihara, A.3
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16
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82655181484
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Prorenin receptor is essential for podocyte autophagy and survival
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This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, nephrotic syndrome and premature death due to deacidification of intracellular vesicles
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Riediger F, Quack I, Qadri F, et al. Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 2011; 22:2193-2202. This study targeted (P)RR 'knock out' to podocytes, resulting in proteinuria, nephrotic syndrome and premature death due to deacidification of intracellular vesicles.
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(2011)
J Am Soc Nephrol
, vol.22
, pp. 2193-2202
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Riediger, F.1
Quack, I.2
Qadri, F.3
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17
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0029858320
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Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver
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Veniant M, Menard J, Bruneval P, et al. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 1996; 98:1966-1970. (Pubitemid 26376283)
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(1996)
Journal of Clinical Investigation
, vol.98
, Issue.9
, pp. 1966-1970
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Veniant, M.1
Menard, J.2
Bruneval, P.3
Morley, S.4
Gonzales, M.F.5
Mullins, J.6
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18
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67049100691
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Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies
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Mercure C, Prescott G, Lacombe MJ, et al. Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies. Hypertension 2009; 53:1062-1069.
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(2009)
Hypertension
, vol.53
, pp. 1062-1069
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Mercure, C.1
Prescott, G.2
Lacombe, M.J.3
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19
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73349109829
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Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver
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Campbell DJ, Karam H, Menard J, et al. Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver. Hypertension 2009; 54:1248-1253.
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(2009)
Hypertension
, vol.54
, pp. 1248-1253
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Campbell, D.J.1
Karam, H.2
Menard, J.3
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20
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37349054998
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Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: Absence of prorenin-induced glomerulosclerosis
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DOI 10.1097/HJH.0b013e3282f0ab66, PII 0000487220080100000017
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Peters B, Grisk O, Becher B, et al. Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: Absence of prorenin-induced glomerulosclerosis. J Hypertens 2008; 26:102-109. (Pubitemid 350301935)
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(2008)
Journal of Hypertension
, vol.26
, Issue.1
, pp. 102-109
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Peters, B.1
Grisk, O.2
Becher, B.3
Wanka, H.4
Kuttler, B.5
Ludemann, J.6
Lorenz, G.7
Rettig, R.8
Mullins, J.J.9
Peters, J.10
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21
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15144347939
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Determinants of interindividual variation of renin and prorenin concentrations: Evidence for a sexual dimorphism of (pro)renin levels in humans
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DOI 10.1097/00004872-199816060-00017
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Danser AH, Derkx FH, Schalekamp MA, et al. Determinants of interindividual variation of renin and prorenin concentrations: Evidence for a sexual dimorphism of prorenin and renin levels in humans. J Hypertens 1998; 16:853-862. (Pubitemid 28247969)
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(1998)
Journal of Hypertension
, vol.16
, Issue.6
, pp. 853-862
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Jan Danser, A.H.1
Derkx, F.H.M.2
Schalekamp, M.A.D.H.3
Hense, H.-W.4
Riegger, G.A.J.5
Schunkert, H.6
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22
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83155180323
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Renin-And prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human prorenin and renin receptor: Does prorenin and renin-prorenin and renin receptor interaction actually occur?
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This study carefully analyzes the concentrations of prorenin and renin required for various types of signaling through (P)RR. These observations have important implications for the sites wherein these interactions might be physiologically important
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Batenburg WW, Lu X, Leijten F, et al. Renin-And prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human prorenin and renin receptor: Does prorenin and renin-prorenin and renin receptor interaction actually occur? Hypertension 2011; 58:1111-1119. This study carefully analyzes the concentrations of prorenin and renin required for various types of signaling through (P)RR. These observations have important implications for the sites wherein these interactions might be physiologically important.
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(2011)
Hypertension
, vol.58
, pp. 1111-1119
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Batenburg, W.W.1
Lu, X.2
Leijten, F.3
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