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Volumn 7, Issue 1, 2012, Pages 76-85

Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions

Author keywords

Aliskiren; Blood pressure reduction; Combination therapy; Prognosis; Renin angiotensin system; Treatment

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ATENOLOL; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CELECOXIB; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROCHLOROTHIAZIDE; IRBESARTAN; LISINOPRIL; LOSARTAN; METFORMIN; PLACEBO; RAMIPRIL; TELMISARTAN; VALSARTAN; WARFARIN; AMIDE; ANTIHYPERTENSIVE AGENT; FUMARIC ACID DERIVATIVE; RENIN;

EID: 84867632500     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488612800492771     Document Type: Review
Times cited : (20)

References (83)
  • 1
    • 23944473130 scopus 로고    scopus 로고
    • Combined effects of HMGCoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis
    • Grothusen C, Bley S, Selle T, et al. Combined effects of HMGCoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis. Atherosclerosis 2005; 182: 57-69.
    • (2005) Atherosclerosis , vol.182 , pp. 57-69
    • Grothusen, C.1    Bley, S.2    Selle, T.3
  • 3
    • 20044392897 scopus 로고    scopus 로고
    • Rethinking the renin-angiotensin system and its role in cardiovascular regulation
    • Pagliaro P, Penna C. Rethinking the renin-angiotensin system and its role in cardiovascular regulation. Cardiovasc Drugs Ther 2005; 19: 77-87.
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 77-87
    • Pagliaro, P.1    Penna, C.2
  • 4
    • 18544369738 scopus 로고    scopus 로고
    • The cardiovascular continuum and renin-angiotensinaldosterone system blockade
    • Dzau V. The cardiovascular continuum and renin-angiotensinaldosterone system blockade. J Hypertens Suppl 2005; 23: S9-17.
    • (2005) J Hypertens Suppl , vol.23
    • Dzau, V.1
  • 5
    • 0038243727 scopus 로고    scopus 로고
    • Renin-angiotensin system and atherothrombotic disease: From genes to treatment
    • Jacoby DS, Rader DJ. Renin-angiotensin system and atherothrombotic disease: from genes to treatment. Arch Intern Med 2003; 163: 1155-64.
    • (2003) Arch Intern Med , vol.163 , pp. 1155-1164
    • Jacoby, D.S.1    Rader, D.J.2
  • 6
    • 0034714978 scopus 로고    scopus 로고
    • The multiple actions of angiotensin II in atherosclerosis
    • Schmidt-Ott KM, Kagiyama S, Phillips MI. The multiple actions of angiotensin II in atherosclerosis. Regul Pept 2000; 93: 65-77.
    • (2000) Regul Pept , vol.93 , pp. 65-77
    • Schmidt-Ott, K.M.1    Kagiyama, S.2    Phillips, M.I.3
  • 7
    • 56849092058 scopus 로고    scopus 로고
    • The renin angiotensin system in the development of cardiovascular disease: Role of aliskiren in risk reduction
    • Verdecchia P, Angeli F, Mazzotta G, Gentile G, Reboldi G. The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction. Vasc Health Risk Manag 2008; 4: 971-81.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 971-981
    • Verdecchia, P.1    Angeli, F.2    Mazzotta, G.3    Gentile, G.4    Reboldi, G.5
  • 8
    • 14044271546 scopus 로고    scopus 로고
    • Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
    • Wood JM, Schnell CR, Cumin F, Menard J, Webb RL. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens 2005; 23: 417-26.
    • (2005) J Hypertens , vol.23 , pp. 417-426
    • Wood, J.M.1    Schnell, C.R.2    Cumin, F.3    Menard, J.4    Webb, R.L.5
  • 9
    • 79955925140 scopus 로고    scopus 로고
    • Advantages and limitations of renin inhibition with aliskiren
    • Azizi M, Frank M, Steichen O, Blanchard A. [Advantages and limitations of renin inhibition with aliskiren]. Ann Pharm Fr 2011; 69: 142-50.
    • (2011) Ann Pharm Fr , vol.69 , pp. 142-150
    • Azizi, M.1    Frank, M.2    Steichen, O.3    Blanchard, A.4
  • 10
    • 50349094508 scopus 로고    scopus 로고
    • Aliskiren
    • Brown MJ. Aliskiren. Circulation 2008; 118: 773-84.
    • (2008) Circulation , vol.118 , pp. 773-784
    • Brown, M.J.1
  • 11
    • 0042661157 scopus 로고    scopus 로고
    • Structure-based design of aliskiren, a novel orally effective renin inhibitor
    • Wood JM, Maibaum J, Rahuel J, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003; 308: 698-705.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 698-705
    • Wood, J.M.1    Maibaum, J.2    Rahuel, J.3
  • 14
    • 84855433634 scopus 로고    scopus 로고
    • Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension
    • Zhu JR, Sun NL, Yang K, et al. Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension. Hypertens Res 2012; 35: 28-33.
    • (2012) Hypertens Res , vol.35 , pp. 28-33
    • Zhu, J.R.1    Sun, N.L.2    Yang, K.3
  • 15
    • 65249182083 scopus 로고    scopus 로고
    • Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): Rationale and study design
    • Parving HH, Brenner BM, McMurray JJ, et al. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant 2009; 24: 1663-71.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1663-1671
    • Parving, H.H.1    Brenner, B.M.2    McMurray, J.J.3
  • 16
    • 85039688537 scopus 로고    scopus 로고
    • ALTITUDE halted: Adverse events when aliskiren added to ACE, ARB therapy. [Updated 2011 December 20]. Available from
    • ALTITUDE halted: Adverse events when aliskiren added to ACE, ARB therapy. [Updated 2011 December 20]. Available from: http://www.theheart.org/article/1331173.do.
  • 17
    • 0023609891 scopus 로고
    • Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets
    • Wood JM, Baum HP, Jobber RA, Neisius D. Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets. J Cardiovasc Pharmacol 1987; 10 (Suppl 7): S96-8.
    • (1987) J Cardiovasc Pharmacol , vol.10 , Issue.SUPPL. 7
    • Wood, J.M.1    Baum, H.P.2    Jobber, R.A.3    Neisius, D.4
  • 18
    • 0021855138 scopus 로고
    • Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin
    • James MN, Sielecki AR. Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin. Biochemistry 1985; 24: 3701-13.
    • (1985) Biochemistry , vol.24 , pp. 3701-3713
    • James, M.N.1    Sielecki, A.R.2
  • 19
    • 33644789557 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren: Where are we now, and where are we going?
    • Azizi M, Webb R, Nussberger J, Hollenberg NK. Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens 2006; 24: 243-56.
    • (2006) J Hypertens , vol.24 , pp. 243-256
    • Azizi, M.1    Webb, R.2    Nussberger, J.3    Hollenberg, N.K.4
  • 20
    • 34547221695 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers
    • Waldmeier F, Glaenzel U, Wirz B, et al. Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos 2007; 35: 1418-28.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1418-1428
    • Waldmeier, F.1    Glaenzel, U.2    Wirz, B.3
  • 22
    • 4744348177 scopus 로고    scopus 로고
    • Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects
    • Dieterle W, Corynen S, Mann J. Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects. Br J Clin Pharmacol 2004; 58: 433-6.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 433-436
    • Dieterle, W.1    Corynen, S.2    Mann, J.3
  • 23
    • 28044453329 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine
    • Dieterle W, Corynen S, Vaidyanathan S, Mann J. Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. Int J Clin Pharmacol Ther 2005; 43: 527-35.
    • (2005) Int J Clin Pharmacol Ther , vol.43 , pp. 527-535
    • Dieterle, W.1    Corynen, S.2    Vaidyanathan, S.3    Mann, J.4
  • 24
    • 39849089447 scopus 로고    scopus 로고
    • Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
    • Andersen K, Weinberger MH, Egan B, et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens 2008; 26: 589-99.
    • (2008) J Hypertens , vol.26 , pp. 589-599
    • Andersen, K.1    Weinberger, M.H.2    Egan, B.3
  • 25
    • 39649106599 scopus 로고    scopus 로고
    • Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension
    • Berman N, Hostetter T. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension. Am J Kidney Dis 2008; 51: 370-2.
    • (2008) Am J Kidney Dis , vol.51 , pp. 370-372
    • Berman, N.1    Hostetter, T.2
  • 26
    • 79958740128 scopus 로고    scopus 로고
    • Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension
    • Black HR, Weinberger MH, Purkayastha D, et al. Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension. J Clin Hypertens (Greenwich) 2011; 13: 571-81.
    • (2011) J Clin Hypertens (Greenwich) , vol.13 , pp. 571-581
    • Black, H.R.1    Weinberger, M.H.2    Purkayastha, D.3
  • 27
    • 77954108460 scopus 로고    scopus 로고
    • The antihypertensive effectiveness and safety of dual RAAS blockade with aliskiren and valsartan
    • Chrysant SG. The antihypertensive effectiveness and safety of dual RAAS blockade with aliskiren and valsartan. Drugs Today (Barc) 2010; 46: 151-62.
    • (2010) Drugs Today (Barc) , vol.46 , pp. 151-162
    • Chrysant, S.G.1
  • 28
    • 42549113198 scopus 로고    scopus 로고
    • Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: A 6-month interim analysis
    • Chrysant SG, Murray AV, Hoppe UC, et al. Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis. Curr Med Res Opin 2008; 24: 1039-47.
    • (2008) Curr Med Res Opin , vol.24 , pp. 1039-1047
    • Chrysant, S.G.1    Murray, A.V.2    Hoppe, U.C.3
  • 29
    • 78349260796 scopus 로고    scopus 로고
    • Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension
    • Chrysant SG, Murray AV, Hoppe UC, et al. Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension. Curr Med Res Opin 2010; 26: 2841-9.
    • (2010) Curr Med Res Opin , vol.26 , pp. 2841-2849
    • Chrysant, S.G.1    Murray, A.V.2    Hoppe, U.C.3
  • 30
    • 79952733572 scopus 로고    scopus 로고
    • Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension
    • Ferdinand KC, Weitzman R, Israel M, Lee J, Purkayastha D, Jaimes EA. Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension. J Am Soc Hypertens 2011; 5: 102-13.
    • (2011) J Am Soc Hypertens , vol.5 , pp. 102-113
    • Ferdinand, K.C.1    Weitzman, R.2    Israel, M.3    Lee, J.4    Purkayastha, D.5    Jaimes, E.A.6
  • 31
    • 77958030338 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of aliskiren, a direct renin inhibitor, in women with hypertension: A pooled analysis of eight studies
    • Gradman AH, Weir MR, Wright M, Bush CA, Keefe DL. Efficacy, safety and tolerability of aliskiren, a direct renin inhibitor, in women with hypertension: a pooled analysis of eight studies. J Hum Hypertens 2010; 24: 721-9.
    • (2010) J Hum Hypertens , vol.24 , pp. 721-729
    • Gradman, A.H.1    Weir, M.R.2    Wright, M.3    Bush, C.A.4    Keefe, D.L.5
  • 32
    • 77949549775 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: A randomized, single-blind, parallel-group, placebo-controlled study
    • Hu P, Bartlett M, Karan RS, et al. Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: a randomized, single-blind, parallel-group, placebo-controlled study. Clin Drug Investig 2010; 30: 221-8.
    • (2010) Clin Drug Investig , vol.30 , pp. 221-228
    • Hu, P.1    Bartlett, M.2    Karan, R.S.3
  • 33
    • 74349119971 scopus 로고    scopus 로고
    • Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction
    • Ito S, Nakura N, Le Breton S, Keefe D. Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction. Hypertens Res 2010; 33: 62-6.
    • (2010) Hypertens Res , vol.33 , pp. 62-66
    • Ito, S.1    Nakura, N.2    Le Breton, S.3    Keefe, D.4
  • 34
    • 79951682271 scopus 로고    scopus 로고
    • Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome
    • Krone W, Hanefeld M, Meyer HF, et al. Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome. J Hum Hypertens 2011; 25: 186-95.
    • (2011) J Hum Hypertens , vol.25 , pp. 186-195
    • Krone, W.1    Hanefeld, M.2    Meyer, H.F.3
  • 35
    • 68249144573 scopus 로고    scopus 로고
    • Longterm safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension
    • Kushiro T, Itakura H, Abo Y, Gotou H, Terao S, Keefe DL. Longterm safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension. Hypertens Res 2009; 32: 169-75.
    • (2009) Hypertens Res , vol.32 , pp. 169-175
    • Kushiro, T.1    Itakura, H.2    Abo, Y.3    Gotou, H.4    Terao, S.5    Keefe, D.L.6
  • 36
    • 67649306830 scopus 로고    scopus 로고
    • Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension
    • Littlejohn TW, 3rd, Trenkwalder P, Hollanders G, Zhao Y, Liao W. Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension. Curr Med Res Opin 2009; 25: 951-9.
    • (2009) Curr Med Res Opin , vol.25 , pp. 951-959
    • Littlejohn III, T.W.1    Trenkwalder, P.2    Hollanders, G.3    Zhao, Y.4    Liao, W.5
  • 37
    • 34447521458 scopus 로고    scopus 로고
    • Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised, double-blind trial
    • Oparil S, Yarows SA, Patel S, Fang H, Zhang J, Satlin A. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet 2007; 370: 221-9.
    • (2007) Lancet , vol.370 , pp. 221-229
    • Oparil, S.1    Yarows, S.A.2    Patel, S.3    Fang, H.4    Zhang, J.5    Satlin, A.6
  • 38
    • 78649929199 scopus 로고    scopus 로고
    • Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy
    • Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Parving HH. Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy. Diabetes Care 2010; 33: 2304-9.
    • (2010) Diabetes Care , vol.33 , pp. 2304-2309
    • Persson, F.1    Lewis, J.B.2    Lewis, E.J.3    Rossing, P.4    Hollenberg, N.K.5    Parving, H.H.6
  • 39
    • 53349092083 scopus 로고    scopus 로고
    • Direct renin inhibition: An evaluation of the safety and tolerability of aliskiren
    • Rashid H. Direct renin inhibition: an evaluation of the safety and tolerability of aliskiren. Curr Med Res Opin 2008; 24: 2627-37.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2627-2637
    • Rashid, H.1
  • 40
    • 60549087324 scopus 로고    scopus 로고
    • Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
    • Schmieder RE, Philipp T, Guerediaga J, et al. Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation 2009; 119: 417-25.
    • (2009) Circulation , vol.119 , pp. 417-425
    • Schmieder, R.E.1    Philipp, T.2    Guerediaga, J.3
  • 41
    • 80155126054 scopus 로고    scopus 로고
    • Long-term safety and tolerability of the oral direct renin inhibitor aliskiren with optional add-on hydrochlorothiazide in patients with hypertension: A randomized, open-label, parallelgroup, multicentre, dose-escalation study with an extension phase
    • Sica D, Gradman AH, Lederballe O, Kolloch RE, Zhang J, Keefe DL. Long-term safety and tolerability of the oral direct renin inhibitor aliskiren with optional add-on hydrochlorothiazide in patients with hypertension: a randomized, open-label, parallelgroup, multicentre, dose-escalation study with an extension phase. Clin Drug Investig 2011; 31: 825-37.
    • (2011) Clin Drug Investig , vol.31 , pp. 825-837
    • Sica, D.1    Gradman, A.H.2    Lederballe, O.3    Kolloch, R.E.4    Zhang, J.5    Keefe, D.L.6
  • 42
    • 38649102508 scopus 로고    scopus 로고
    • Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
    • Uresin Y, Taylor AA, Kilo C, et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst 2007; 8: 190-8.
    • (2007) J Renin Angiotensin Aldosterone Syst , vol.8 , pp. 190-198
    • Uresin, Y.1    Taylor, A.A.2    Kilo, C.3
  • 43
    • 33947543780 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects
    • Vaidyanathan S, Reynolds C, Yeh CM, et al. Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects. J Clin Pharmacol 2007; 47: 453-60.
    • (2007) J Clin Pharmacol , vol.47 , pp. 453-460
    • Vaidyanathan, S.1    Reynolds, C.2    Yeh, C.M.3
  • 44
    • 33846456943 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairment
    • Vaidyanathan S, Warren V, Yeh C, Bizot MN, Dieterich HA, Dole WP. Pharmacokinetics, safety, and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairment. J Clin Pharmacol 2007; 47: 192-200.
    • (2007) J Clin Pharmacol , vol.47 , pp. 192-200
    • Vaidyanathan, S.1    Warren, V.2    Yeh, C.3    Bizot, M.N.4    Dieterich, H.A.5    Dole, W.P.6
  • 45
    • 84862884800 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of aliskiren monotherapy administered with a light meal in elderly hypertensive patients: A randomized, double-blind, placebo-controlled, dose-response evaluation study
    • [Epub ahead of print]
    • Villa G, Le Breton S, Ibram G, Keefe DL. Efficacy, safety, and tolerability of aliskiren monotherapy administered with a light meal in elderly hypertensive patients: A randomized, double-blind, placebo-controlled, dose-response evaluation study. J Clin Pharmacol 2011 [Epub ahead of print].
    • (2011) J Clin Pharmacol
    • Villa, G.1    Le Breton, S.2    Ibram, G.3    Keefe, D.L.4
  • 46
    • 81255188035 scopus 로고    scopus 로고
    • Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension and obesity or metabolic syndrome
    • Weinberger MH, Izzo JL, Jr., Purkayastha D, Weitzman R, Black HR. Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension and obesity or metabolic syndrome. J Am Soc Hypertens 2011; 5: 489-97.
    • (2011) J Am Soc Hypertens , vol.5 , pp. 489-497
    • Weinberger, M.H.1    Izzo Jr., J.L.2    Purkayastha, D.3    Weitzman, R.4    Black, H.R.5
  • 47
    • 34447621764 scopus 로고    scopus 로고
    • Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: A pooled analysis
    • Weir MR, Bush C, Anderson DR, Zhang J, Keefe D, Satlin A. Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: a pooled analysis. J Am Soc Hypertens 2007; 1: 264-77.
    • (2007) J Am Soc Hypertens , vol.1 , pp. 264-277
    • Weir, M.R.1    Bush, C.2    Anderson, D.R.3    Zhang, J.4    Keefe, D.5    Satlin, A.6
  • 48
    • 34548855067 scopus 로고    scopus 로고
    • A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension
    • Strasser RH, Puig JG, Farsang C, Croket M, Li J, van Ingen H. A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension. J Hum Hypertens 2007; 21: 780-7.
    • (2007) J Hum Hypertens , vol.21 , pp. 780-787
    • Strasser, R.H.1    Puig, J.G.2    Farsang, C.3    Croket, M.4    Li, J.5    van Ingen, H.6
  • 49
    • 67849128863 scopus 로고    scopus 로고
    • Blood pressure lowering efficacy of renin inhibitors for primary hypertension: A Cochrane systematic review
    • Musini VM, Fortin PM, Bassett K, Wright JM. Blood pressure lowering efficacy of renin inhibitors for primary hypertension: a Cochrane systematic review. J Hum Hypertens 2009; 23: 495-502.
    • (2009) J Hum Hypertens , vol.23 , pp. 495-502
    • Musini, V.M.1    Fortin, P.M.2    Bassett, K.3    Wright, J.M.4
  • 50
    • 33846781398 scopus 로고    scopus 로고
    • Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
    • Kushiro T, Itakura H, Abo Y, Gotou H, Terao S, Keefe DL. Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertens Res 2006; 29: 997-1005.
    • (2006) Hypertens Res , vol.29 , pp. 997-1005
    • Kushiro, T.1    Itakura, H.2    Abo, Y.3    Gotou, H.4    Terao, S.5    Keefe, D.L.6
  • 51
    • 34247867955 scopus 로고    scopus 로고
    • Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
    • Jordan J, Engeli S, Boye SW, Le Breton S, Keefe DL. Direct Renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension 2007; 49: 1047-55.
    • (2007) Hypertension , vol.49 , pp. 1047-1055
    • Jordan, J.1    Engeli, S.2    Boye, S.W.3    Le Breton, S.4    Keefe, D.L.5
  • 52
    • 33947182655 scopus 로고    scopus 로고
    • Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
    • Oh BH, Mitchell J, Herron JR, Chung J, Khan M, Keefe DL. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol 2007; 49: 1157-63.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1157-1163
    • Oh, B.H.1    Mitchell, J.2    Herron, J.R.3    Chung, J.4    Khan, M.5    Keefe, D.L.6
  • 53
    • 33845785350 scopus 로고    scopus 로고
    • Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
    • Pool JL, Schmieder RE, Azizi M, et al. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens 2007; 20: 11-20.
    • (2007) Am J Hypertens , vol.20 , pp. 11-20
    • Pool, J.L.1    Schmieder, R.E.2    Azizi, M.3
  • 54
    • 33845366982 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
    • Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007; 25: 217-26.
    • (2007) J Hypertens , vol.25 , pp. 217-226
    • Villamil, A.1    Chrysant, S.G.2    Calhoun, D.3
  • 55
    • 36348998335 scopus 로고    scopus 로고
    • Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension
    • Dahlof B, Anderson D, Arora V. Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension. J Clin Hypertens 2007; 9(Suppl A): A157.
    • (2007) J Clin Hypertens , vol.9 , Issue.SUPPL. A
    • Dahlof, B.1    Anderson, D.2    Arora, V.3
  • 56
    • 56749085787 scopus 로고    scopus 로고
    • Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
    • Dietz R, Dechend R, Yu CM, et al. Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension. J Renin Angiotensin Aldosterone Syst 2008; 9: 163-75.
    • (2008) J Renin Angiotensin Aldosterone Syst , vol.9 , pp. 163-175
    • Dietz, R.1    Dechend, R.2    Yu, C.M.3
  • 57
    • 84871357668 scopus 로고    scopus 로고
    • FDA. Food and Drug Administration. Drug product label. Tekturna, NDA no. 021985. Available from
    • FDA. Food and Drug Administration. Drug product label. Tekturna, NDA no. 021985. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021985s019lbl.pdf. 2010.
    • (2010)
  • 58
    • 36248931230 scopus 로고    scopus 로고
    • Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy
    • Drummond W, Munger MA, Rafique Essop M, Maboudian M, Khan M, Keefe DL. Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy. J Clin Hypertens (Greenwich) 2007; 9: 742-50.
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , pp. 742-750
    • Drummond, W.1    Munger, M.A.2    Rafique, E.M.3    Maboudian, M.4    Khan, M.5    Keefe, D.L.6
  • 59
    • 79960471052 scopus 로고    scopus 로고
    • Safety and tolerability of the direct renin inhibitor aliskiren in combination with angiotensin receptor blockers and thiazide diuretics: A pooled analysis of clinical experience of 12,942 patients
    • White WB, Bresalier R, Kaplan AP, et al. Safety and tolerability of the direct renin inhibitor aliskiren in combination with angiotensin receptor blockers and thiazide diuretics: a pooled analysis of clinical experience of 12,942 patients. J Clin Hypertens (Greenwich) 2011; 13: 506-16.
    • (2011) J Clin Hypertens (Greenwich) , vol.13 , pp. 506-516
    • White, W.B.1    Bresalier, R.2    Kaplan, A.P.3
  • 60
    • 83055186450 scopus 로고    scopus 로고
    • Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus
    • Townsend RR, Forker AD, Bhosekar V, Yadao A, Keefe DL. Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus. J Clin Hypertens (Greenwich) 2011; 13: 889-97.
    • (2011) J Clin Hypertens (Greenwich) , vol.13 , pp. 889-897
    • Townsend, R.R.1    Forker, A.D.2    Bhosekar, V.3    Yadao, A.4    Keefe, D.L.5
  • 61
    • 2642575030 scopus 로고    scopus 로고
    • Combined blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists
    • Azizi M, Menard J. Combined blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Circulation 2004; 109: 2492-9.
    • (2004) Circulation , vol.109 , pp. 2492-2499
    • Azizi, M.1    Menard, J.2
  • 62
    • 0025073099 scopus 로고
    • Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition
    • Mooser V, Nussberger J, Juillerat L, et al. Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition. J Cardiovasc Pharmacol 1990; 15: 276-82.
    • (1990) J Cardiovasc Pharmacol , vol.15 , pp. 276-282
    • Mooser, V.1    Nussberger, J.2    Juillerat, L.3
  • 63
    • 0031688757 scopus 로고    scopus 로고
    • Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
    • Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension 1998; 32: 387-92.
    • (1998) Hypertension , vol.32 , pp. 387-392
    • Hollenberg, N.K.1    Fisher, N.D.2    Price, D.A.3
  • 64
    • 0031017144 scopus 로고    scopus 로고
    • Functional and biochemical analysis of angiotensin II-forming pathways in the human heart
    • Wolny A, Clozel JP, Rein J, et al. Functional and biochemical analysis of angiotensin II-forming pathways in the human heart. Circ Res 1997; 80: 219-27.
    • (1997) Circ Res , vol.80 , pp. 219-227
    • Wolny, A.1    Clozel, J.P.2    Rein, J.3
  • 65
    • 59049107132 scopus 로고    scopus 로고
    • Renal aspirin: Will all patients with chronic kidney disease one day take spironolactone?
    • Bomback AS, Kshirsagar AV, Klemmer PJ. Renal aspirin: will all patients with chronic kidney disease one day take spironolactone? Nat Clin Pract Nephrol 2009; 5: 74-5.
    • (2009) Nat Clin Pract Nephrol , vol.5 , pp. 74-75
    • Bomback, A.S.1    Kshirsagar, A.V.2    Klemmer, P.J.3
  • 66
    • 0343484977 scopus 로고    scopus 로고
    • Blood pressureindependent effects in rats with human renin and angiotensinogen genes
    • Mervaala E, Muller DN, Schmidt F, et al. Blood pressureindependent effects in rats with human renin and angiotensinogen genes. Hypertension 2000; 35: 587-94.
    • (2000) Hypertension , vol.35 , pp. 587-594
    • Mervaala, E.1    Muller, D.N.2    Schmidt, F.3
  • 67
    • 42349086752 scopus 로고    scopus 로고
    • Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine
    • Nussberger J, Aubert JF, Bouzourene K, Pellegrin M, Hayoz D, Mazzolai L. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine. Hypertension 2008; 51: 1306-11.
    • (2008) Hypertension , vol.51 , pp. 1306-1311
    • Nussberger, J.1    Aubert, J.F.2    Bouzourene, K.3    Pellegrin, M.4    Hayoz, D.5    Mazzolai, L.6
  • 68
    • 34848907212 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats
    • Kelly DJ, Zhang Y, Moe G, Naik G, Gilbert RE. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia 2007; 50: 2398-404.
    • (2007) Diabetologia , vol.50 , pp. 2398-2404
    • Kelly, D.J.1    Zhang, Y.2    Moe, G.3    Naik, G.4    Gilbert, R.E.5
  • 69
    • 14844363404 scopus 로고    scopus 로고
    • Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebolike tolerability in hypertensive patients
    • Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebolike tolerability in hypertensive patients. Circulation 2005; 111: 1012-8.
    • (2005) Circulation , vol.111 , pp. 1012-1018
    • Gradman, A.H.1    Schmieder, R.E.2    Lins, R.L.3    Nussberger, J.4    Chiang, Y.5    Bedigian, M.P.6
  • 71
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Yusuf S, Teo KK, Pogue J et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547-59.
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3
  • 72
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
    • McMurray JJ, Pitt B, Latini R, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008; 1: 17-24.
    • (2008) Circ Heart Fail , vol.1 , pp. 17-24
    • McMurray, J.J.1    Pitt, B.2    Latini, R.3
  • 73
    • 77955921291 scopus 로고    scopus 로고
    • Aliskiren for geriatric lowering of systolic hypertension: A randomized controlled trial
    • Duprez DA, Munger MA, Botha J, Keefe DL, Charney AN. Aliskiren for geriatric lowering of systolic hypertension: a randomized controlled trial. J Hum Hypertens 2010; 24: 600-8.
    • (2010) J Hum Hypertens , vol.24 , pp. 600-608
    • Duprez, D.A.1    Munger, M.A.2    Botha, J.3    Keefe, D.L.4    Charney, A.N.5
  • 74
    • 79952186619 scopus 로고    scopus 로고
    • Comparison of aliskiren/hydrochlorothiazide combination therapy with hydrochlorothiazide monotherapy in older patients with stage 2 systolic hypertension: Results of the ACTION study
    • Basile J, Babazadeh S, Lillestol M, Botha J, Yurkovic C, Weitzman R. Comparison of aliskiren/hydrochlorothiazide combination therapy with hydrochlorothiazide monotherapy in older patients with stage 2 systolic hypertension: results of the ACTION study. J Clin Hypertens (Greenwich) 2011; 13: 162-9.
    • (2011) J Clin Hypertens (Greenwich) , vol.13 , pp. 162-169
    • Basile, J.1    Babazadeh, S.2    Lillestol, M.3    Botha, J.4    Yurkovic, C.5    Weitzman, R.6
  • 75
    • 33847633400 scopus 로고    scopus 로고
    • Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004
    • Ong KL, Cheung BM, Man YB, Lau CP, Lam KS. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007; 49: 69-75.
    • (2007) Hypertension , vol.49 , pp. 69-75
    • Ong, K.L.1    Cheung, B.M.2    Man, Y.B.3    Lau, C.P.4    Lam, K.S.5
  • 76
    • 79955671214 scopus 로고    scopus 로고
    • Medical treatment of hypertension in Switzerland. The 2009 Swiss Hypertension Survey (SWISSHYPE)
    • Brenner R, Waeber B, Allemann Y. Medical treatment of hypertension in Switzerland. The 2009 Swiss Hypertension Survey (SWISSHYPE). Swiss Med Wkly 2011; 141: w13169.
    • (2011) Swiss Med Wkly , vol.141
    • Brenner, R.1    Waeber, B.2    Allemann, Y.3
  • 77
    • 25444454353 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in doubletransgenic rats
    • Pilz B, Shagdarsuren E, Wellner M, et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in doubletransgenic rats. Hypertension. 2005; 46: 569-76.
    • (2005) Hypertension , vol.46 , pp. 569-576
    • Pilz, B.1    Shagdarsuren, E.2    Wellner, M.3
  • 78
    • 61349170589 scopus 로고    scopus 로고
    • Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    • Solomon SD, Appelbaum E, Manning WJ, et al. Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009; 119: 530-7.
    • (2009) Circulation , vol.119 , pp. 530-537
    • Solomon, S.D.1    Appelbaum, E.2    Manning, W.J.3
  • 79
    • 77952977869 scopus 로고    scopus 로고
    • Clinical trials update from the American College of Cardiology meeting 2010: Dose, aspire, connect, stich, stop-af, cabana, race ii, everest ii, accord, and navigator
    • Cleland JG, Coletta AP, Buga L, Ahmed D, Clark AL. Clinical trials update from the American College of Cardiology meeting 2010: dose, aspire, connect, stich, stop-af, cabana, race ii, everest ii, accord, and navigator. Eur J Heart Fail 2010; 12: 623-9.
    • (2010) Eur J Heart Fail , vol.12 , pp. 623-629
    • Cleland, J.G.1    Coletta, A.P.2    Buga, L.3    Ahmed, D.4    Clark, A.L.5
  • 80
    • 78751646571 scopus 로고    scopus 로고
    • Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): A randomised, parallel-group trial
    • Brown MJ, McInnes GT, Papst CC, Zhang J, MacDonald TM. Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial. Lancet 2011; 377: 312-20.
    • (2011) Lancet , vol.377 , pp. 312-320
    • Brown, M.J.1    McInnes, G.T.2    Papst, C.C.3    Zhang, J.4    Macdonald, T.M.5
  • 81
    • 85039674947 scopus 로고    scopus 로고
    • Aliskiren Pregnancy and Breastfeeding Warnings. [Updated 2012 January 20]. Available from
    • Aliskiren Pregnancy and Breastfeeding Warnings. [Updated 2012 January 20]. Available from: http://www.drugs.com/pregnancy/aliskiren.html.
  • 82
    • 78650344825 scopus 로고    scopus 로고
    • Rationale and design of the multicentre, randomized, double-blind, placebocontrolled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT)
    • Gheorghiade M, Albaghdadi M, Zannad F, et al. Rationale and design of the multicentre, randomized, double-blind, placebocontrolled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT). Eur J Heart Fail 2011; 13: 100-6.
    • (2011) Eur J Heart Fail , vol.13 , pp. 100-106
    • Gheorghiade, M.1    Albaghdadi, M.2    Zannad, F.3
  • 83
    • 78650380191 scopus 로고    scopus 로고
    • Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: Rationale and design of the aliskiren trial to minimize outcomes in patients with heart failure (ATMOSPHERE) study
    • Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the aliskiren trial to minimize outcomes in patients with heart failure (ATMOSPHERE) study. Eur J Heart Fail 2011; 13: 107-14.
    • (2011) Eur J Heart Fail , vol.13 , pp. 107-114
    • Krum, H.1    Massie, B.2    Abraham, W.T.3


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