Integrin-linked kinase (ILK) expression correlates with tumor severity in clear cell renal carcinoma

Pathology and Oncology Research

Volumn 19, Issue 1, 2013, Pages 27-33

  Engelman, Míriam De Fátima Brasil ^a   Grande, Rogério Mendes ^a   Naves, Marcelo Andery ^b   De Franco, Marcello Fabiano ^b   De Paulo Castro Teixeira, Vicente ^b  

^a UNIVERSIDADE DO VALE DO SAPUCAÍ   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Carcinoma; Human; Immunohistochemistry; Integrin linked kinase; Renal cell; Tissue array analysis

Indexed keywords

BETA CATENIN; INTEGRIN LINKED KINASE; UVOMORULIN;

APOPTOSIS; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER PROGNOSIS; CANCER STAGING; CELL PROLIFERATION; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; PROTEIN EXPRESSION; TISSUE MICROARRAY; TUMOR VOLUME; UPREGULATION;

APOPTOSIS; BETA CATENIN; CADHERINS; CARCINOMA, RENAL CELL; CELL GROWTH PROCESSES; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; NEOPLASM GRADING; PROTEIN-SERINE-THREONINE KINASES; STATISTICS, NONPARAMETRIC; TISSUE ARRAY ANALYSIS;

EID: 84873099977     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-012-9554-4     Document Type: Article

References (45)

1. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L et al (1996) Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379:91-96
2. Dedhar S, Williams B, Hannigan G (1999) Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling. Trends Cell Biol 9:319-323
3. Wu C, Keightley SY, Leung-Hagesteijn C et al (1998) Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 273:528-536
4. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S (1998) Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A 95:11211-11216
5. Hannigan G, Troussard AA, Dedhar S (2005) Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5:51-63
6. Wu C, Dedhar S (2001) Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol 155:505-510
7. Persad S, Attwell S, Gray V et al (2000) Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci U S A 97:3207-3212
8. Novak A, Hsu S-C, Leung-Hagesteijn C et al (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways. Proc Natl Acad Sci U S A 95:4374-4379
9. D'Amico M, Hulit J, Atullah DF et al (2000) The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3B and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem 75:32649-32657
10. Oloumi A, McPhee T, Dedhar S (2004) Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta 169:1-15
11. Graff JR, Deddens JA, Konicek BW et al (2001) Integrin-linked kinase expression increases with prostate tumor grade. Clin Cancer Res 7:1987-1991
12. Marotta A, Tan C, Gray V et al (2001) Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene 20:6250-6267
13. Marotta A, Parhar K, Owen D, Dedhar S, Salh B (2003) Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer 88:1755-1762
14. Bravou V, Klironomos G, Papadaki E, Taraviras S, Varakis J (2006) ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. J Pathol 208:91-99
15. Ito R, Oue N, Zhu X et al (2003) Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch 442:118-123
16. Ahmed N, Riley C, Oliva K, Stutt E, Rice GE, Quinn MA (2003) Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. J Pathol 201:229-237
17. Dai DL, Makretsov N, Campos EI et al (2003) Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res 9:4409-4414
18. Chung DH, Lee JI, Kook MC et al (1998) ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour. Virchows Arch 433:113-117
19. Takanami I (2005) Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer. BMC Cancer 5:1
20. Okamura M, Yamaji S, Nagashima Y et al (2007) Prognostic value of integrin beta1-ILK-pAkt signaling pathway in non-small cell lung cancer. Hum Pathol 38:1081-1091
21. Watzka SB, Rauscher-Pötsch I, Stubenberger E et al (2010) Immunoreactivity of integrin-linked kinase in primary non-small-cell lung cancer and survival after curative resection. Eur J Cardiothorac Surg 38:254-259
22. Papanikolaou S, Bravou V, Gyftopoulos K, Nakas D, Repanti M, Papadaki H (2010) ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion. Histopathology 56:799-809
23. Schaeffer DF, Assi K, Chan K et al (2010) Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma. Virchows Arch 456:261-268
24. Peroukides S, Bravou V, Varakis J, Alexopoulos A, Kalofonos H, Papadaki H (2008) ILK overexpression in human hepatocellular carcinoma and liver cirrhosis correlates with activation of Akt. Oncol Rep 20:1337-1344
25. Goulioumis AK, Bravou V, Varakis J, Goumas P, Papadaki H (2008) Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas. Virchows Arch 453:511-519
26. Matsui Y, Assi K, Ogawa O et al (2012) The importance of integrin-linked kinase in the regulation of bladder cancer invasion. Int J Cancer 130:521-531
27. Yoshino S, Kato M, Okada K (2000) Clinical significance of angiogenesis, proliferation and apoptosis in renal cell carcinoma. Anticancer Res 20:591-594
28. Kirkali Z, Yorukoglu K, Ozkara E, Kazimoglu H, Mungan U (2001) Proliferative activity, angiogenesis and nuclear morphometry in renal cell carcinoma. Int J Urol 8:697-703
29. Kononen J, Bubendorf L, Kallioniemi A et al (1998) Tissue microarrays for high-through put molecular profiling of tumor specimens. Nat Med 4:844-847
30. Kallakuri BVS, Sheehan CE, Winn-Deen E et al (2001) Decreased expression of catenins (α and β), p120, CTNM and E-cadherin gene promoter methylation in prostatic adenocarcinomas. Cancer 92:2786-2795
31. Rao JY, Seligson D, Visapaa H et al (2002) Tissue microarray analysis for cytoskeletal actin-associated biomarkes gelsolin and cadherin in urothelial carcinoma. Cancer 95:1247-1257
32. Skacel M, Skilton B, Pettay JD, Tubbs RR (2002) Tissue microarrays: a powerful tool for high-throughput an analisis of clinical specimens - a review of the method whit validation data. Appl Immunohistochem Mol Morphol 10:1-6
33. Haase M, Gmach CC, Eke I, Hehlgans S, Baretton GB, Cordes N (2008) Expression of integrin-linked kinase is increased in differentiated cells. J Histochem Cytochem 56:819-829
34. Thiery JP (2004) Epithelial-mesenchymal transition: twist in development and metastasis. Cell 1014:1125-1136
35. Katagiri A, Watanabe R, Tomita Y (2000) E-cadherin expression in renal cell cancer and its significance in metastasis and survival. Br J Cancer 85:801-804
36. Pecina-Slaus N, Gall-TroSelj K, Slaus M et al (2004) Genetic changes of the E-cadherin and APC tumour suppressor genes in clear renal cell carcinoma. Pathology 36:145-151
37. Slaton JW, Inoue K, Perrotte P et al (2001) Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol 158:735-743
38. Younes MN, Kim S, Yigitbasi OG et al (2005) Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Mol Cancer Ther 4:1146-1156
39. Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE (2005) RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res 11:3433-3438
40. Edwards LA, Thiessen B, Dragowska WH et al (2005) Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene 24:3596-3605
41. Han L, Pamukcu R, Thompson J (2002) β-catenin signaling: therapeutic strategies in oncology. Cancer Biol Ther 1:621-625
42. Guo L, Kuroda N, Miyazaki E et al (2001) The complementary role of beta-catenin in diagnosing various subtypes of renal cell carcinomas and its up-regulation in conventional renal cell carcinomas with high nuclear grades. Oncol Rep 8:521-526
43. Kim YS, Kang YK, Kim JB, Han SA, Kim KI, Paik SR (2000) β-catenin expression and mutational analysis in renal cell carcinomas. Pathol Int 50:725-730
44. Shiina H, Igawa M, Breault J et al (2003) The human T-cell factor-4 gene splicing isoforms, WNT pathway and apoptosis in renal cell carcinoma. Clin Cancer Res 9:2121-2132
45. Hindermann W, Berndt A, Wunderlich H, Katenkamp D, Kosmehl H (1997) Quantitative evaluation of apoptosis and proliferation in renal cell carcinoma. Correlation to tumor subtype, cytological grade according to thoenes-classification and the occurrence of metastasis. Pathol Res Pract 193:1-7