The importance of integrin-linked kinase in the regulation of bladder cancer invasion

International Journal of Cancer

Volumn 130, Issue 3, 2012, Pages 521-531

  Matsui, Yoshiyuki ^a   Assi, Kiran ^a   Ogawa, Osamu ^b   Raven, Peter A ^a   Dedhar, Shoukat ^a,c   Gleave, Martin E ^a   Salh, Baljinder ^a   So, Alan I ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b KYOTO UNIVERSITY   (Japan)

^c BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

bladder cancer; E cadherin; integrin linked kinase; invasion; MMP 9

Indexed keywords

GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; INTEGRIN LINKED KINASE; REGULATOR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN; ZEB1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER CANCER; CANCER GROWTH; CANCER INVASION; CELL INVASION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY;

ANIMALS; CADHERINS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; PROTEIN-SERINE-THREONINE KINASES; URINARY BLADDER NEOPLASMS;

EID: 82255175153     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26008     Document Type: Article

References (44)

1. Clark PE,. Bladder cancer. Curr Opin Oncol 2007; 19: 241-7. (Pubitemid 46597484)
2. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, et al,. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-15. (Pubitemid 351636299)
3. Pettitt J,. The cadherin superfamily. WormBook 2005: 1-9.
4. Hannigan G, Troussard AA, Dedhar S,. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005; 5: 51-63. (Pubitemid 40052325)
5. Esfandiarei M, Suarez A, Amaral A, Si X, Rahmani M, Dedhar S, McManus BM,. Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury. Circ Res 2006; 99: 354-61. (Pubitemid 44253691)
6. Wang B, Yurecko RS, Dedhar S, Cleary PP,. Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells. Cell Microbiol 2006; 8: 257-66. (Pubitemid 43356048)
7. Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S,. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 2001; 153: 1161-74.
8. D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K, Moon RT, Davis R, et al,. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem 2000; 275: 32649-57.
9. Troussard AA, Tan C, Yoganathan TN, Dedhar S,. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. Mol Cell Biol 1999; 19: 7420-7. (Pubitemid 29493405)
10. McPhee TR, McDonald PC, Oloumi A, Dedhar S,. Integrin-linked kinase regulates E-cadherin expression through PARP-1. Dev Dyn 2008; 237: 2737-47.
11. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC,. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004; 6: 931-40. (Pubitemid 39359846)
12. Marotta A, Parhar K, Owen D, Dedhar S, Salh B,. Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer 2003; 88: 1755-62. (Pubitemid 36760421)
13. Schaeffer DF, Assi K, Chan K, Buczkowski AK, Chung SW, Scudamore CH, Weiss A, Salh B, Owen DA,. Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma. Virchows Arch 2010; 456: 261-8.
14. Graff JR, Deddens JA, Konicek BW, Colligan BM, Hurst BM, Carter HW, Carter JH,. Integrin-linked kinase expression increases with prostate tumor grade. Clin Cancer Res 2001; 7: 1987-91. (Pubitemid 32994836)
15. Ito R, Oue N, Zhu X, Yoshida K, Nakayama H, Yokozaki H, Yasui W,. Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch 2003; 442: 118-23. (Pubitemid 36337658)
16. Dai DL, Makretsov N, Campos EI, Huang C, Zhou Y, Huntsman D, Martinka M, Li G,. Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res 2003; 9: 4409-14. (Pubitemid 37248398)
17. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S,. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 2001; 276: 27462-9.
18. Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S,. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 2004; 5: 79-90. (Pubitemid 38121598)
19. Sobin LH, Fleming ID,. TNM Classification of Malignant Tumors, 5th edn. Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 1997; 80: 1803-4.
20. Elliott AY, Cleveland P, Cervenka J, Castro AE, Stein N, Hakala TR, Fraley EE,. Characterization of a cell line from human transitional cell cancer of the urinary tract. J Natl Cancer Inst 1974; 53: 1341-49.
21. Elliott AY, Bronson DL, Cervenka J, Stein N, Fraley EE,. Properties of cell lines established from transitional cell cancers of the human urinary tract. Cancer Res 1977; 37: 1279-89. (Pubitemid 8104860)
22. Baumgart E, Cohen MS, Silva Neto B, Jacobs MA, Wotkowicz C, Rieger-Christ KM, Biolo A, Zeheb R, Loda M, Libertino JA, Summerhayes IC,. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Clin Cancer Res 2007; 13: 1685-94. (Pubitemid 46952933)
23. Kim JH, Tuziak T, Hu L, Wang Z, Bondaruk J, Kim M, Fuller G, Dinney C, Grossman HB, Baggerly K, Zhang W, Czerniak B,. Alterations in transcription clusters underlie development of bladder cancer along papillary and nonpapillary pathways. Lab Invest 2005; 85: 532-49. (Pubitemid 40523945)
24. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S,. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 1996; 379: 91-6. (Pubitemid 26008142)
25. Nikolopoulos SN, Turner CE,. Molecular dissection of actopaxin-integrin- linked kinase-paxillin interactions and their role in subcellular localization. J Biol Chem 2002; 277: 1568-75. (Pubitemid 34968915)
26. Yamaji S, Suzuki A, Sugiyama Y, Koide Y, Yoshida M, Kanamori H, Mohri H, Ohno S, Ishigatsubo Y,. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. J Cell Biol 2001; 153: 1251-64. (Pubitemid 34289263)
27. Tu Y, Huang Y, Zhang Y, Hua Y, Wu C,. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. J Cell Biol 2001; 153: 585-98. (Pubitemid 34280144)
28. Nikolopoulos SN, Turner CE,. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J Biol Chem 2001; 276: 23499-505.
29. Persad S, Dedhar S,. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metast Rev 2003; 22: 375-84. (Pubitemid 36791893)
30. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S,. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 1998; 95: 11211-6. (Pubitemid 28450107)
31. Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, et al,. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol 2004; 24: 8134-44. (Pubitemid 39167462)
32. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S,. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 2000; 97: 3207-12. (Pubitemid 30183280)
33. Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S,. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 2003; 278: 22374-8. (Pubitemid 36830287)
34. Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG, Dedhar S,. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene 2001; 20: 133-40. (Pubitemid 32142346)
35. Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J,. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 2002; 277: 39209-16. (Pubitemid 35190890)
36. Adam L, Zhong M, Choi W, Qi W, Nicoloso M, Arora A, Calin G, Wang H, Siefker-Radtke A, McConkey D, Bar-Eli M, Dinney C,. miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Clin Cancer Res 2009; 15: 5060-72.
37. Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD, Dedhar S,. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene 2000; 19: 5444-52. (Pubitemid 32000911)
38. Younes MN, Kim S, Yigitbasi OG, Mandal M, Jasser SA, Dakak YY, Schiff BA, El-Naggar A, Bekele BN, Mills GB, Myers JN,. Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Mol Cancer Ther 2005; 4: 1146-56. (Pubitemid 41149562)
39. Edwards LA, Woo J, Huxham LA, Verreault M, Dragowska WH, Chiu G, Rajput A, Kyle AH, Kalra J, Yapp D, Yan H, Minchinton AI, et al,. Suppression of VEGF secretion and changes in glioblastoma multiform microenvironment by inhibition of integrin-linked kinase (ILK). Mol Cancer Ther 2008; 7: 59-70.
40. Deryugina EI, Quigley JP,. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 2006; 25: 9-34. (Pubitemid 43723979)
41. Davies B, Waxman J, Wasan H, Abel P, Williams G, Krausz T, Neal D, Thomas D, Hanby A, Balkwill F,. Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res 1993; 53: 5365-9. (Pubitemid 23342150)
42. Kawamura K, Kamiya N, Suyama T, Shimbo M, Oosumi N, Suzuki H, Ueda T, Tobe T, Igarashi T, Ito H, Ishikura H,. In situ gelatinolytic activity correlates with tumor progression and prognosis in patients with bladder cancer. J Urol 2004; 172: 1480-4. (Pubitemid 39249753)
43. Sayan AE, Griffiths TR, Pal R, Browne GJ, Ruddick A, Yagci T, Edwards R, Mayer NJ, Qazi H, Goyal S, Fernandez S, Straatman K, et al,. SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer. Proc Natl Acad Sci USA 2009; 106: 14884-9.
44. Slaton JW, Millikan R, Inoue K, Karashima T, Czerniak B, Shen Y, Yang Y, Benedict WF, Dinney CP,. Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy. J Urol 2004; 171: 570-4. (Pubitemid 38090431)