Prognostic value of integrin β1-ILK-pAkt signaling pathway in non-small cell lung cancer

Human Pathology

Volumn 38, Issue 7, 2007, Pages 1081-1091

  Okamura, Mayumi ^a   Yamaji, Satoshi ^a   Nagashima, Yoji ^a   Nishikawa, Masanori ^b   Yoshimoto, Noboru ^b   Kido, Yasuhiro ^b   Iemoto, Yoichi ^b   Aoki, Ichiro ^a   Ishigatsubo, Yoshiaki ^a  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Fujisawa City Hospital   (Japan)

Author keywords

ILK; Integrin 1; Lung cancer; Phospho Akt

Indexed keywords

BETA1 INTEGRIN; INTEGRIN LINKED KINASE; PROTEIN KINASE B;

ADULT; AGED; ARTICLE; CANCER TISSUE; CONTROLLED STUDY; FEMALE; HAZARD RATIO; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MALE; MULTIVARIATE ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADULT; AGED; ANTIGENS, CD29; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

EID: 34250192581     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.01.003     Document Type: Article

References (30)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2006. CA Cancer J Clin 56 (2006) 106-130
2. Zhu C.Q., Shih W., Ling C.H., et al. Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation. J Clin Pathol 59 (2006) 790-800
3. Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032
4. Oshita F., Kameda Y., Ikehara M., et al. Increased expression of integrin β1 is a poor prognostic factor in small-cell lung cancer. Anticancer Res 22 (2002) 1065-1070
5. Oshita F., Ito H., Ikehara M., et al. Prognostic impact of survivin, cyclin D1, integrin β1, and VEGF in patients with small adenocarcinoma of stage I lung cancer. Am J Clin Oncol 27 (2004) 425-428
6. Hannigan G., Troussard A.A., and Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5 (2005) 51-63
7. Boudeau J., Miranda-Saavedra D., Barton G.J., and Alessi D.R. Emerging roles of pseudokinases. Trends Cell Biol 16 (2006) 443-452
8. Tan C., Costello P., Sanghera J., et al. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene 20 (2001) 133-140
9. Yau C.Y., Wheeler J.J., Sutton K.L., and Hedley D.W. Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res 65 (2005) 1497-1504
10. Schmitz K.J., Otterbach F., Callies R., et al. Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases. Mod Pathol 17 (2004) 15-21
11. David O., Jett J., LeBeau H., et al. Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 10 (2004) 6865-68671
12. Han J.Y., Kim H.S., Lee S.H., et al. Immunohistochemical expression of integrins and extracellular matrix proteins in non-small cell lung cancer: correlation with lymph node metastasis. Lung Cancer 41 (2003) 65-70
13. Bravou V., Klironomos G., Papadaki E., et al. Integrin-linked kinase (ILK) expression in human colon cancer. Br J Cancer 89 (2003) 2340-2341
14. Bravou V., Klironomos G., Papadaki E., et al. ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. J Pathol 208 (2006) 91-99
15. Chung D.H., Lee J.I., Kook M.C., et al. ILK(β1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour. Virchows Arch 433 (1998) 113-117
16. Ito R., Oue N., Zhu X., et al. Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch 442 (2003) 118-123
17. Ahmed N., Riley C., Oliva K., et al. Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. J Pathol 201 (2003) 229-237
18. Marotta A., Parhar K., Owen D., et al. Characterisation of integrin-linked kinase signaling in sporadic human colon cancer. Br J Cancer 88 (2003) 1755-1762
19. Sawai H., Okada Y., Funahashi H., et al. Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival. Oncogene 25 (2006) 3237-3246
20. Younes M.N., Kim S., Yigitbasi O.G., et al. Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Mol Cancer Ther 4 (2005) 1146-1156
21. Graff J.R., Deddens J.A., Konicek B.W., et al. Integrin-linked kinase expression increases with prostate tumor grade. Clin Cancer Res 7 (2001) 1987-1991
22. Dai D.L., Makretsov N., Campos E.I., et al. Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res 9 (2003) 4409-4414
23. Takanami I. Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer. BMC Cancer 5 (2005) 1
24. Hirami Y., Aoe M., Tsukuda K., et al. Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers. Cancer Lett 214 (2004) 157-164
25. Balsara B.R., Pei J., Mitsuuchi Y., et al. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis 25 (2004) 2053-2059
26. Legate K.R., Montanez E., Kudlacek O., and Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 7 (2006) 20-31
27. Sakai T., Li S., Docheva D., et al. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev 17 (2003) 926-940
28. Levinson H., Turner C.E., and Ehrlich H.P. Integrin-linked kinase: a possible role in scar contracture. Ann Plast Surg 52 (2004) 204-211
29. Hannigan G.E., Bayani J., Weksberg R., et al. Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4. Genomics 42 (1997) 177-179
30. Bepler G., Gautam A., McIntyre L.M., et al. Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer. J Clin Oncol 20 (2002) 1353-1360