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Volumn 1, Issue 6, 2002, Pages 621-625

β-catenin signaling: Therapeutic strategies in oncology

Author keywords

Apoptosis; cGMP; Colon cancer; Cyclin D1; Exisulind; GSk3 ; PDE; Protein kinase G; SAANDs; catenin

Indexed keywords

ANTINEOPLASTIC AGENT; APC PROTEIN; AXIN PROTEIN; BETA CATENIN; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DRUG DERIVATIVE; PROTEIN; REPRESSOR PROTEIN; SULINDAC; SULINDAC SULFONE; TRANSACTIVATOR PROTEIN;

EID: 0038243190     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.309     Document Type: Review
Times cited : (71)

References (60)
  • 1
    • 0033913603 scopus 로고    scopus 로고
    • Control of beta-catenin signaling in tumor development
    • Behrens J. Control of beta-catenin signaling in tumor development. Ann NY Acad Sci 2000; 910:21-33.
    • (2000) Ann NY Acad Sci , vol.910 , pp. 21-33
    • Behrens, J.1
  • 2
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
    • DOI 10.1126/science.287.5458.1606
    • Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 2000; 287:1606-9. (Pubitemid 30127755)
    • (2000) Science , vol.287 , Issue.5458 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 3
    • 0030779038 scopus 로고    scopus 로고
    • Serine phosphorylation-regulated ubiquitination and degradation of beta- catenin
    • DOI 10.1074/jbc.272.40.24735
    • Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW. Serine phosphorylation-regulated ubiquitination and degradation of beta- catenin. J Biol Chem 1997; 272:24735-8. (Pubitemid 27415637)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.40 , pp. 24735-24738
    • Orford, K.1    Crockett, C.2    Jensen, J.P.3    Weissman, A.M.4    Byers, S.W.5
  • 4
    • 0033553532 scopus 로고    scopus 로고
    • Substrate targeting in the ubiquitin system
    • DOI 10.1016/S0092-8674(00)80752-7
    • Laney JD, Hochstrasser M. Substrate targeting in the ubiquitin system. Cell 1999; 97:427-30. (Pubitemid 29231165)
    • (1999) Cell , vol.97 , Issue.4 , pp. 427-430
    • Laney, J.D.1    Hochstrasser, M.2
  • 6
    • 0036295950 scopus 로고    scopus 로고
    • Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45
    • DOI 10.1016/S0006-291X(02)00485-0, PII S0006291X02004850
    • Hagen T, Vidal-Puig A. Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45. Biochem Biophys Res Commun 2002; 294:324-8. (Pubitemid 34694097)
    • (2002) Biochemical and Biophysical Research Communications , vol.294 , Issue.2 , pp. 324-328
    • Hagen, T.1    Vidal-Puig, A.2
  • 7
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • DOI 10.1016/S0092-8674(02)00685-2
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002; 108:837-47. (Pubitemid 34327534)
    • (2002) Cell , vol.108 , Issue.6 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.-H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 8
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996; 272:1023-6. (Pubitemid 26259322)
    • (1996) Science , vol.272 , Issue.5264 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 9
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • DOI 10.1016/S0092-8674(00)81333-1
    • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87:159-70. (Pubitemid 26358996)
    • (1996) Cell , vol.87 , Issue.2 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 10
    • 0029047954 scopus 로고
    • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
    • Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C, Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci USA 1995; 92:4482-86.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4482-4486
    • Oshima, M.1    Oshima, H.2    Kitagawa, K.3    Kobayashi, M.4    Itakura, C.5    Taketo, M.6
  • 11
    • 0035972159 scopus 로고    scopus 로고
    • DeltaN89beta-catenin induces precocious development, differentiation, neoplasia in mammary gland
    • Imbert A, Eelkema R, Jordan S, Feiner H, Cowin P. Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol 2001; 153:555-68. (Pubitemid 34280142)
    • (2001) Journal of Cell Biology , vol.152 , Issue.3 , pp. 555-568
    • Imbert, A.1    Eelkema, R.2    Jordan, S.3    Feiner, H.4    Cowin, P.5
  • 14
    • 0037129305 scopus 로고    scopus 로고
    • In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis
    • Chesire DR, Ewing CM, Gage WR, Isaacs WB. In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis. Oncogene 2002; 21:2679-94.
    • (2002) Oncogene , vol.21 , pp. 2679-2694
    • Chesire, D.R.1    Ewing, C.M.2    Gage, W.R.3    Isaacs, W.B.4
  • 16
    • 0032813907 scopus 로고    scopus 로고
    • beta-Catenin expression pattern in stage I and II ovarian carcinomas: Relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome
    • Gamallo C, Palacios J, Moreno G, Calvo dM, Suarez A, Armas A. beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome. Am J Pathol 1999; 155:527-36. (Pubitemid 29370402)
    • (1999) American Journal of Pathology , vol.155 , Issue.2 , pp. 527-536
    • Gamallo, C.1    Palacios, J.2    Moreno, G.3    De Mora, J.C.4    Suarez, A.5    Armas, A.6
  • 19
    • 0035877115 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma
    • DOI 10.1002/ijc.1270
    • Omholt K, Platz A, Ringborg U, Hansson J. Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer 2001; 92:839-42. (Pubitemid 32467373)
    • (2001) International Journal of Cancer , vol.92 , Issue.6 , pp. 839-842
    • Omholt, K.1    Platz, A.2    Ringborg, U.3    Hansson, J.4
  • 20
    • 0032937232 scopus 로고    scopus 로고
    • Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
    • Rimm DL, Caca K, Hu G, Harrison FB, Fearon ER. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 1999; 154:325-9. (Pubitemid 29094082)
    • (1999) American Journal of Pathology , vol.154 , Issue.2 , pp. 325-329
    • Rimm, D.L.1    Caca, K.2    Hu, G.3    Harrison, F.B.4    Fearon, E.R.5
  • 21
    • 0030900696 scopus 로고    scopus 로고
    • Stabilization of beta-catenin by genetic defects in melanoma cell lines
    • DOI 10.1126/science.275.5307.1790
    • Rubinfeld B, Robbins P, El Gamil M, Albert I, Porfiri E, Polakis P. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997; 275:1790-2. (Pubitemid 27136716)
    • (1997) Science , vol.275 , Issue.5307 , pp. 1790-1792
    • Rubinfeld, B.1    Robbins, P.2    El-Gamil, M.3    Albert, I.4    Porfiri, E.5    Polakis, P.6
  • 22
    • 0035028066 scopus 로고    scopus 로고
    • Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation
    • Saegusa M, Okayasu I. Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation. J Pathol 2001; 194:59-67.
    • (2001) J Pathol , vol.194 , pp. 59-67
    • Saegusa, M.1    Okayasu, I.2
  • 23
    • 0028176375 scopus 로고
    • Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells
    • Sommers CL, Gelmann EP, Kemler R, Cowin P, Byers SW. Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells. Cancer Res 1994; 54:3544-52.
    • (1994) Cancer Res , vol.54 , pp. 3544-3552
    • Sommers, C.L.1    Gelmann, E.P.2    Kemler, R.3    Cowin, P.4    Byers, S.W.5
  • 24
    • 0035146996 scopus 로고    scopus 로고
    • Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma
    • Sunaga N, Kohno T, Kolligs FT, Fearon ER, Saito R, Yokota J. Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. Genes Chromosomes Cancer 2001; 30:316-21.
    • (2001) Genes Chromosomes Cancer , vol.30 , pp. 316-321
    • Sunaga, N.1    Kohno, T.2    Kolligs, F.T.3    Fearon, E.R.4    Saito, R.5    Yokota, J.6
  • 25
    • 0034283030 scopus 로고    scopus 로고
    • Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    • Truica CI, Byers S, Gelmann EP. Beta-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Res 2000; 60:4709-13.
    • (2000) Cancer Res , vol.60 , pp. 4709-4713
    • Truica, C.I.1    Byers, S.2    Gelmann, E.P.3
  • 26
    • 2642673582 scopus 로고    scopus 로고
    • beta-Catenin mutations in human prostate cancer
    • Voeller HJ, Truica CI, Gelmann EP. Beta-catenin mutations in human prostate cancer. Cancer Res 1998; 58:2520-3. (Pubitemid 28275418)
    • (1998) Cancer Research , vol.58 , Issue.12 , pp. 2520-2523
    • James, V.H.1    Truica, C.I.2    Gelmann, E.P.3
  • 27
    • 0033948526 scopus 로고    scopus 로고
    • Sequence variants of the Axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding
    • DOI 10.1002/1098-2264(200008)28:4<443::AID-GCC10>3.0.CO;2-D
    • Webster MT, Rozycka M, Sara E, Davis E, Smalley M, Young N et al. Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes Cancer 2000; 28:443-53. (Pubitemid 30451797)
    • (2000) Genes Chromosomes and Cancer , vol.28 , Issue.4 , pp. 443-453
    • Webster, M.-T.1    Rozycka, M.2    Sara, E.3    Davis, E.4    Smalley, M.5    Young, N.6    Dale, T.C.7    Wooster, R.8
  • 29
    • 0034840950 scopus 로고    scopus 로고
    • Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
    • DOI 10.1038/ncb0901-793
    • Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 2001; 3:793-801. (Pubitemid 32842684)
    • (2001) Nature Cell Biology , vol.3 , Issue.9 , pp. 793-801
    • Ryo, A.1    Nakamura, M.2    Wulf, G.3    Liou, Y.-C.4    Lu, K.P.5
  • 30
    • 0032830931 scopus 로고    scopus 로고
    • TCF transcription factors: Molecular switches in carcinogenesis
    • Roose J, Clevers H. TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1999; 1424:M23-37.
    • (1999) Biochim Biophys Acta , vol.1424
    • Roose, J.1    Clevers, H.2
  • 31
    • 0037124062 scopus 로고    scopus 로고
    • The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli
    • DOI 10.1074/jbc.M200135200
    • Mulholland DJ, Cheng H, Reid K, Rennie PS, Nelson CC. The androgen receptor can promote Beta -catenin nuclear translocation independently of adenomatous polyposis coli. J Biol Chem 2002; 277:17933-43. (Pubitemid 34967604)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.20 , pp. 17933-17943
    • Mulholland, D.J.1    Cheng, H.2    Reid, K.3    Rennie, P.S.4    Nelson, C.C.5
  • 32
    • 0037036393 scopus 로고    scopus 로고
    • Liganded androgen receptor interaction with beta-catenin: Nuclear co-localization and modulation of transcriptional activity in neuronal cells
    • DOI 10.1074/jbc.M200545200
    • Pawlowski JE, Ertel JR, Allen MP, Xu M, Butler C, Wilson EM, et al. Liganded Androgen Receptor Interaction with beta -Catenin. Nuclear co-localization and modulation of transcriptional activity in neuroal cells. J Biol Chem 2002; 277:20702-10. (Pubitemid 34967374)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.23 , pp. 20702-20710
    • Pawlowski, J.E.1    Ertel, J.R.2    Allen, M.P.3    Xu, M.4    Butler, C.5    Wilson, E.M.6    Wierman, M.E.7
  • 33
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • DOI 10.1126/science.275.5307.1787
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275:1787-90. (Pubitemid 27136715)
    • (1997) Science , vol.275 , Issue.5307 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 34
    • 0034653689 scopus 로고    scopus 로고
    • The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
    • Shih IM, Yu J, He TC, Vogelstein B, Kinzler KW. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res 2000; 60:1671-6. (Pubitemid 30183440)
    • (2000) Cancer Research , vol.60 , Issue.6 , pp. 1671-1676
    • Shih, I.-M.1    Yu, J.2    He, T.-C.3    Vogelstein, B.4    Kinzler, K.W.5
  • 35
    • 0033568521 scopus 로고    scopus 로고
    • Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
    • Carlson B, Lahusen T, Singh S, Loaiza-Perez A, Worland PJ, Pestell R et al. Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res 1999; 59:4634-41.
    • (1999) Cancer Res , vol.59 , pp. 4634-4641
    • Carlson, B.1    Lahusen, T.2    Singh, S.3    Loaiza-Perez, A.4    Worland, P.J.5    Pestell, R.6
  • 36
    • 0033615352 scopus 로고    scopus 로고
    • PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • DOI 10.1016/S0092-8674(00)81664-5
    • He TC, Chan TA, Vogelstein B, Kinzler KW. PPARdelta is an APC-regulated target of non-steroidal anti-inflammatory drugs. Cell 1999; 99:335-45. (Pubitemid 29519912)
    • (1999) Cell , vol.99 , Issue.3 , pp. 335-345
    • He, T.-C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 37
    • 0036830654 scopus 로고    scopus 로고
    • Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation
    • DOI 10.1016/S0006-2952(02)01345-X, PII S000629520201345X
    • Li H, Liu L, David M, Whitehead CM, Chen M, Fetter J, et al. Pro-apoptotic Actions of Exisulind and CP461 in SW480 Colon Tumor Cells Involve b-Catenin and Cyclin D1 Down Regulation . Biochem Pharmacol 2002; 64:1325-36. (Pubitemid 35248250)
    • (2002) Biochemical Pharmacology , vol.64 , Issue.9 , pp. 1325-1336
    • Li, H.1    Liu, L.2    David, M.L.3    Whitehead, C.M.4    Chen, M.5    Fetter, J.R.6    Sperl, G.J.7    Pamukcu, R.8    Thompson, W.J.9
  • 38
    • 0034234978 scopus 로고    scopus 로고
    • Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin
    • Thompson WJ, Piazza GA, Li H, Liu L, Fetter J, Zhu B, et al. Exisulind induction of apoptosis involves guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res 2000; 60:3338-42. (Pubitemid 30482142)
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3338-3342
    • Thompson, W.J.1    Piazza, G.A.2    Li, H.3    Liu, L.4    Fetter, J.5    Zhu, B.6    Sperl, G.7    Ahnen, D.8    Pamukcu, R.9
  • 39
    • 4243615014 scopus 로고    scopus 로고
    • Exisulind Induces apoptosis in colonic tumor cells lacking APC mutations by cyclic GMP mediated beta-catenin reduction
    • Thompson WJ, Liu L, Li H, Fetter J, Sperl G, Piazza G, et al. Exisulind Induces apoptosis in colonic tumor cells lacking APC mutations by cyclic GMP mediated beta-catenin reduction. Gastroenterology 2000; 118:A670.
    • (2000) Gastroenterology , vol.118
    • Thompson, W.J.1    Liu, L.2    Li, H.3    Fetter, J.4    Sperl, G.5    Piazza, G.6
  • 41
    • 0034469062 scopus 로고    scopus 로고
    • Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis
    • Stoner GD, Budd GT, Ganapathi R, DeYoung B, Kresty LA, Nitert M, et al. Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis. Adv Exp Med Biol 1999; 470:45-53.
    • (1999) Adv Exp Med Biol , vol.470 , pp. 45-53
    • Stoner, G.D.1    Budd, G.T.2    Ganapathi, R.3    DeYoung, B.4    Kresty, L.A.5    Nitert, M.6
  • 42
    • 0032216792 scopus 로고    scopus 로고
    • Colon cancer prevention by NSAIDs: What is the mechanism of action?
    • Ahnen DJ. Colon cancer prevention by NSAIDs: what is the mechanism of action? Eur J Surg Suppl 1998;:111-4.
    • (1998) Eur J Surg Suppl , pp. 111-114
    • Ahnen, D.J.1
  • 43
    • 0029451275 scopus 로고
    • Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
    • Alberts DS, Hixson L, Ahnen D, Bogert C, Einspahr J, Paranka N, et al. Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase? J Cell Biochem Suppl 1995; 22:18-23.
    • (1995) J Cell Biochem Suppl , vol.22 , pp. 18-23
    • Alberts, D.S.1    Hixson, L.2    Ahnen, D.3    Bogert, C.4    Einspahr, J.5    Paranka, N.6
  • 46
    • 0030968757 scopus 로고    scopus 로고
    • Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction
    • Piazza GA, Rahm AK, Finn TS, Fryer BH, Li H, Stoumen AL, et al. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. Cancer Res 1997; 57:2452-9. (Pubitemid 27255906)
    • (1997) Cancer Research , vol.57 , Issue.12 , pp. 2452-2459
    • Piazza, G.A.1    Rahm, A.K.2    Finn, T.S.3    Fryer, B.H.4    Li, H.5    Stoumen, A.L.6    Pamukcu, R.7    Ahnen, D.J.8
  • 50
    • 0031661654 scopus 로고    scopus 로고
    • Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone)
    • Malkinson AM, Koski KM, Dwyer-Nield LD, Rice PL, Rioux N, Castonguay A et al. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone). Carcinogenesis 1998; 19(8):1353-1356.
    • (1998) Carcinogenesis , vol.19 , Issue.8 , pp. 1353-1356
    • Malkinson, A.M.1    Koski, K.M.2    Dwyer-Nield, L.D.3    Rice, P.L.4    Rioux, N.5    Castonguay, A.6
  • 52
    • 0035844219 scopus 로고    scopus 로고
    • Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1
    • Soh JW, Mao Y, Liu L, Thompson WJ, Pamukcu R, Weinstein IB. Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. J Biol Chem 2001; 276(19):16406-16410.
    • (2001) J Biol Chem , vol.276 , Issue.19 , pp. 16406-16410
    • Soh, J.W.1    Mao, Y.2    Liu, L.3    Thompson, W.J.4    Pamukcu, R.5    Weinstein, I.B.6
  • 55
    • 79960824515 scopus 로고    scopus 로고
    • Exisulind Induced Regression of Sporadic Adenomatous Polyps in a Randomized, Double-Blind, Placebo Controlled Trial
    • #104807
    • Arber D, Rex D, Sjodahl R, Hultcrantz R, Kuwada S. Exisulind Induced Regression of Sporadic Adenomatous Polyps in a Randomized, Double-Blind, Placebo Controlled Trial . DDW Abstract 2002 2002; 11(#104807).
    • (2002) DDW Abstract , vol.2002 , pp. 611
    • Arber, D.1    Rex, D.2    Sjodahl, R.3    Hultcrantz, R.4    Kuwada, S.5
  • 56
    • 0001619114 scopus 로고    scopus 로고
    • Exisulind Prevents Adenoma Formation in Familial Adenomatous Polyposis (FAP)
    • Burke C, Stolk R, Arber N, Hultcrantz R, Bjork J, Syngal S, et al. Exisulind Prevents Adenoma Formation in Familial Adenomatous Polyposis (FAP). Gastroenterology 2000; 118(4):3604.
    • (2000) Gastroenterology , vol.118 , Issue.4 , pp. 3604
    • Burke, C.1    Stolk, R.2    Arber, N.3    Hultcrantz, R.4    Bjork, J.5    Syngal, S.6
  • 57
    • 0001416531 scopus 로고    scopus 로고
    • Exisulind,a Pro-apoptotic Drug, Prevents New Polyp Formation in Patients with Familial Adenomatous Polyposis
    • Phillips RK, Hultcrantz R, Bjork J, Beveridge I, Arber N, Syngal S, et al. Exisulind,a Pro-apoptotic Drug, Prevents New Polyp Formation in Patients with Familial Adenomatous Polyposis. Gut 2000; 47(3):A2-3.
    • (2000) Gut , vol.47 , Issue.3
    • Phillips, R.K.1    Hultcrantz, R.2    Bjork, J.3    Beveridge, I.4    Arber, N.5    Syngal, S.6
  • 60
    • 79960808239 scopus 로고    scopus 로고
    • Exisulind and CP461 Down-regulate Activated Wnt signaling in Colon Cancer Cells by Direct PKG, but not GSK3b, Phosphorylation of b-Catenin
    • #2993
    • Li H, David M, Chen M, Liu L, Underwood T, Alila L, et al. Exisulind and CP461 Down-regulate Activated Wnt signaling in Colon Cancer Cells by Direct PKG, But not GSK3b, Phosphorylation of b-Catenin. Proc AACR 2002; 43(#2993).
    • (2002) Proc AACR , vol.43
    • Li, H.1    David, M.2    Chen, M.3    Liu, L.4    Underwood, T.5    Alila, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.