Attenuated desensitization of β-adrenergic receptor by water-soluble N-nitrosamines that induce S-nitrosylation without NO release

Circulation Research

Volumn 112, Issue 2, 2013, Pages 327-334

  Makita, Noriko ^a   Kabasawa, Yoji ^b   Otani, Yuko ^b   Firman, ^b   Sato, Junichiro ^a   Hashimoto, Makiko ^a   Nakaya, Michio ^b,c   Nishihara, Hiroaki ^b,c   Nangaku, Masaomi ^a   Kurose, Hitoshi ^b,c   Ohwada, Tomohiko ^b   Iiri, Taroh ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

adrenergic receptor; desensitization; G protein coupled receptor kinases; nitrosamines; S nitrosylation

Indexed keywords

BETA ADRENERGIC RECEPTOR; CARBOXYLIC ACID; ETHYLENE GLYCOL; G PROTEIN COUPLED RECEPTOR KINASE 2; ISOPRENALINE; NITRIC OXIDE; NITROSAMINE; TRIETHYLENE GLYCOL;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG SYNTHESIS; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; HEK293 CELLS; HUMANS; MYOCYTES, CARDIAC; NITRIC OXIDE; NITROSAMINES; RATS; RECEPTORS, ADRENERGIC, BETA-2; SOLUBILITY; WATER;

EID: 84872876881     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.277665     Document Type: Article

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