7-Azabicyclo[2.2.1]heptane as a structural motif to block mutagenicity of nitrosamines

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2726-2741

  Ohwada, Tomohiko ^a   Ishikawa, Satoko ^b   Mine, Yusuke ^c   Inami, Keiko ^c   Yanagimoto, Takahiro ^a   Karaki, Fumika ^a   Kabasawa, Yoji ^a   Otani, Yuko ^a   Mochizuki, Masataka ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Ames test; Bond dissociation energy; Mutagenicity; Nitrosamines

Indexed keywords

7 AZABICYCLO[2.2.1]HEPTANE; DIMETHYLNITROSAMINE; NITROSAMINE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DISSOCIATION; HYDROXYLATION; MUTAGENICITY; NONHUMAN; RAT; SALMONELLA TYPHIMURIUM;

ANIMALS; BICYCLO COMPOUNDS; HEPTANES; HUMANS; HYDROXYLATION; MUTAGENICITY TESTS; MUTAGENS; NITROSAMINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 79954425141     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.049     Document Type: Article

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