Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation

Circulation Research

Volumn 112, Issue 2, 2013, Pages 246-256

  Johnson, Daniel M ^a   Heijman, Jordi ^a,b,f   Bode, Elizabeth F ^c   Greensmith, David J ^c   Van Der Linde, Henk ^d   Abi Gerges, Najah ^e   Eisner, David A ^c   Trafford, Andrew W ^c   Volders, Paul G A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^e ASTRAZENECA   (United Kingdom)

^f UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

Author keywords

adrenergic receptors; action potentials; arrhythmia; calcium; sarcoplasmic reticulum

Indexed keywords

CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; DELAYED RECTIFIER POTASSIUM CHANNEL; FLECAINIDE; I KAPPA B; ISOPRENALINE; MAGNESIUM; RYANODINE RECEPTOR;

ACTION POTENTIAL; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEAT TO BEAT VARIABILITY; CALCIUM TRANSPORT; CARDIOVASCULAR PARAMETERS; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART REPOLARIZATION; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; QT PROLONGATION; SARCOPLASMIC RETICULUM; TORSADE DES POINTES;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; DOGS; FEMALE; HEART RATE; HEART VENTRICLES; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM;

EID: 84872862581     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.275735     Document Type: Article

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