Cellular mechanism of calcium-mediated triggered activity in the heart

Circulation Research

Volumn 96, Issue 5, 2005, Pages 535-542

  Katra, Rodolphe P ^a   Laurita, Kenneth R ^a,b  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Arrhythmias; Delayed after depolarization; Intracellular calcium; Optical mapping; Triggered activity

Indexed keywords

CALCIUM;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DOG; ENDOCARDIUM; EPICARDIUM; HEART ARRHYTHMIA; HEART CONTRACTION; HEART DEPOLARIZATION; HEART PACING; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CARDIAC PACING, ARTIFICIAL; DOGS; ENDOCARDIUM; HEART CONDUCTION SYSTEM; ION TRANSPORT; ISOPROTERENOL; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN CULTURE TECHNIQUES; RECEPTORS, ADRENERGIC, BETA; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR; VENTRICULAR PREMATURE COMPLEXES;

EID: 16244421990     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000159387.00749.3c     Document Type: Article

References (43)

1. Priori SG, Mantica M, Schwartz PJ. Delayed after depolarizations elicited in vivo by left stellate ganglion stimulation. Circulation. 1988;78: 178-185.
2. Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of β-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation. 1998;98:2314-2322.
3. Pogwizd SM, McKenzie JP, Cain ME. Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation. 1998;98:2404-2414.
4. Janse MJ, Vermeulen JT, Opthof T, Coronel R, Wilms-Schopman FJG, Rademaker HME, Baartscheer A, Dekker LRC. Arrhythmogenesis in heart failure. J Cardiovasc Electrophysiol. 2001;12:496-499.
5. Verkerk AO, Veldkamp MW, Baartscheer A, Schumacher CA, Klöpping C, Van Ginneken ACG, Ravesloot JH. Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts. Circulation. 2001;104:2728-2733.
6. Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, Sorrentino V, Danieli GA. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation. 2001;103:196-200.
7. Marks AR. Clinical implications of cardiac ryanodine receptor/calcium release channel mutations linked to sudden cardiac death. Circulation. 2002;106:8-10.
8. George CH, Higgs GV, Lai FA. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ Res. 2003;93:531-540.
9. Marban E, Robinson SW, Wier WG. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J Clin Invest. 1986;78:1185-1192.
10. 2+ waves in Purkinje cells - Role in action potential initiation. Circ Res. 2000;86:448-455.
11. Priori SG, Corr PB. Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. Am J Physiol. 1990;258: H1796-H1805.
12. Johnson N, Danilo PJr, Wit AL, Rosen MR. Characteristics of initiation and termination of catecholamine-induced triggered activity in atrial fibers of the coronary sinus. Circulation. 1986;74:1168-1179.
13. Patterson E, Scherlag BJ. Szabo B, Lazzara R. Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs. J Electrocardiol. 1997;30:217-224.
14. 2+ waves during triggered propagated contractions in intact trabeculae. Am J Physiol. 1998;274: H266-H276.
15. Kimura S, Camera J, Kozlovskis P, Bassett A, Myerburg R. Delayed afterdepolarizations and triggered activity induced in feline Purkinje fibers by adrenergic stimulation in the presence of elevated calcium levels. Circulation. 1984;70:1074-1082.
16. 2+ overload. Exp Physiol. 1993;78:79-93.
17. Laurita KR, Katra RP, Wible B, Wan XP, Koo MH. Transmural heterogeneity of calcium handling in canine. Circ Res. 2003;92:668-675.
18. Katra RP, Laurita KR. Transmural optical mapping of calcium and voltage reveals delayed afterdepolarization and aftercontractions in LQT1. Circulation. 2003;108:IV-54. Abstract.
19. Ks does not induce early afterdepolarization activity but promotes β-adrenergic agonist-induced delayed afterdepolarization activity. J Cardiovasc Electrophysiol. 2000; 11:458-465.
20. Yan GX, Antzelevitch C. Cellular basis for the electrocardiographic J wave. Circulation. 1996;93:372-379.
21. 2+] in whole perfused rat hearts using Indo-1 fluorometry. Biophys J. 1993;65:1973-1982.
22. Katra RP, Pruvot E, Laurita KR. Intracellular calcium handling heterogeneities in intact guinea pig hearts. Am J Physiol. 2004;286: H648-H656.
23. Laurita KR, Singal A. Mapping action potentials and calcium transients simultaneously from the intact heart. Am J Physiol. 2001;280: H2053-H2060.
24. Thomas GP, Gerlach U, Antzelevitch C. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003;41:140-147.
25. Shimizu W, Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol. 2000;35:778-786.
26. Schreieck J, Wang YG, Gjini V, Korth M, Zrenner B, Schömig A, Schmitt C. Differential effect of β-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new Class III anti-arrhythmics dofetilide, ambasilide, and chromanol 293B. J Cardiovasc Electrophysiol 1997;8:1420-1430.
27. 2+ current and arrhythmogenic triggered activity in guinea pig ventricular myocytes. J Cardiovasc Electrophysiol. 1998;9:718-726.
28. Na activation in β-stimulated cardiac myocytes. J Physiol. 2000;527:455-466.
29. Whalley DW, Wendt DJ, Grant AO. Basic concepts in cellular cardiac electrophysiology: Part 1: Ion channels, membrane currents, and the action potential. Pacing Clin Electrophysiol. 1995;18:1556-1574.
30. 2+ release causes myocyte depolarization: underlying mechanism and threshold for triggered action potentials. Circ Res. 2000;87:774-780.
31. 2+ release cause a triggered arrhythmia? Cellular versus tissue requirements. Circ Res. 2000;87:725-727.
32. Asano Y, Davidenko JM, Baxter WT, Gray RA, Jalife J. Optical mapping of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart. J Am Coll Cardiol. 1997;29:831-842.
33. El-Sherif N, Caref EB, Yin H, Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: tridimensional mapping of activation and recovery patterns. Circ Res. 1996; 79:474-492.
34. Pogwizd SM. Focal mechanisms underlying ventricular tachycardia during prolonged ischemic cardiomyopathy. Circulation. 1994;90:1441-1458.
35. Qian YW, Clusin WT, Lin SF, Han J, Sung RJ. Spatial heterogeneity of calcium transient alternans during the early phase of myocardial ischemia in the blood-perfused rabbit heart. Circulation. 2001;104:2082-2087.
36. Egdell RM, De Souza AI, Macleod KT. Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytes. Cardiovasc Res. 2000;47:769-777.
37. Baartscheer A, Schumacher CA, Belterman CNW, Coronel R, Fiolet JWT. SR calcium handling and calcium after-transients in a rabbit model of heart failure. Cardiovasc Res. 2003;58:99-108.
38. Berridge MJ, Galione A. Cytosolic calcium oscillators. FASEB J. 1988; 2:3074-3082.
39. Tweedie D, Harding SE, MacLeod KT. Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytes. J Mol Cell Cardiol. 2000;32:261-272.
40. 2+ waves in rat ventricular myocytes. J Physiol. 1999;518:173-186.
41. 2+ sensing sites. Biophys J. 1998; 75:2801-2810.
42. ter Keurs HE, Zhang YM, Davidoff AW, Boyden PA, Wakayama Y, Miura M. Damage induced arrhythmias: mechanisms and implications. Can J Physiol Pharmacol. 2001;79:73-81.
43. Sheehan KA, Blatter LA. Regulation of junctional and non-junctional sarcoplasmic reticulum calcium release in excitation-contraction coupling in cat atrial myocytes. J Physiol. 2003;546:119-135.