Inhibitory effects and molecular mechanisms of selenium-containing tea polysaccharides on human breast cancer MCF-7 cells

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 3, 2013, Pages 579-588

  He, Nianwu ^a,b   Shi, Xiaolong ^a   Zhao, Yan ^c   Tian, Lingmin ^a   Wang, Dongying ^a   Yang, Xingbin ^a  

^a SHAANXI NORMAL UNIVERSITY   (China)

^b SHANGLUO UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; breast cancer; MCF 7 cells; selenium; tea polysaccharide

Indexed keywords

APOPTOTIC PATHWAYS; BREAST CANCER; CANCER CELLS; CASPASE-3; CELL CYCLE; DIETARY SUPPLEMENTATION; GREEN TEA; GROWTH INHIBITION; HEALTH BENEFITS; HUMAN BREAST CANCER; INHIBITORY EFFECT; MCF-7 BREAST CANCER CELLS; MCF-7 CELLS; MOLECULAR MECHANISM; PHASE ARREST; UP-REGULATION;

CELL DEATH; CELL GROWTH; DISEASES; GROWTH KINETICS; POLYSACCHARIDES;

SELENIUM;

ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE 3; CASPASE 9; CDK2 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 2; POLYSACCHARIDE; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SELENIUM;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMISTRY; DRUG EFFECT; FEMALE; HUMAN; IC 50; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION; TEA; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL CYCLE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; MITOCHONDRIA; POLYSACCHARIDES; REACTIVE OXYGEN SPECIES; SELENIUM; SIGNAL TRANSDUCTION; TEA; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84872854275     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3036929     Document Type: Article

References (45)

1. Sanmartín, C.; Plano, D.; Sharma, A. K.; Palop, J. A. Selenium compounds, apoptosis and other types of cell death: an overview for cancer therapy Int. J. Mol. Sci. 2012, 13, 9649-9672
2. Fang, W. X.; Wu, P. W.; Hu, R. Z. Geochemical research of the impact of Se-Cu-Mo-V-bearing coal layers on the environment in Pingli County, Shaanxi Province, China J. Geochem. Explor. 2003, 80, 105-115
3. Schrauzer, G. N. Nutritional selenium supplements: product types, quality, and safety J. Am. Coll. Nutr. 2001, 20, 1-4
4. Margaret, P. R. The importance of selenium to human health Lancet 2000, 356, 233-241
5. Diaz-Alarcón, J. P.; Navarro-Alarcón, M.; López-García de la Serrana, H.; Asensio-Drima, C.; López-Martínez, M. C. Determination and chemical speciation of selenium in farmlands from southeastern Spain: relation to levels found in sugar cane J. Agric. Food Chem. 1996, 44, 2423-2427
6. Xu, J.; Zhu, S. G.; Yang, F. M.; Cheng, L. C.; Hu, Y.; Pan, G. X.; Hu, Q. H. The influence of selenium on the antioxidant activity of green tea J. Sci. Food Agric. 2003, 83, 451-455
7. Xu, J.; Yang, F. M.; Chen, L. C.; Hu, Q. H. Effect of selenium on increasing the antioxidant activity of tea leaves harvested during the early spring tea producing season J. Agric. Food Chem. 2003, 51, 1081-1084
8. Molan, A. L.; Flanagan, J.; Wei, W.; Moughan, P. J. Selenium-containing green tea has higher antioxidant and prebiotic activities than regular green tea Food Chem. 2009, 114, 829-835
9. Yu, F.; Sheng, J. C.; Xu, J.; An, X. X.; Hu, Q. H. Antioxidant activities of crude tea polyphenols, polysaccharides and proteins of selenium-enriched tea and regular green tea Eur. Food Res. Technol. 2007, 225, 843-848
10. Li, H. J.; Li, F.; Yang, F. M.; Fang, Y.; Xin, Z. H.; Zhao, L. Y.; Hu, Q. H. Size effect of se-enriched green tea particles on in vitro antioxidant and antitumor activities J. Agric. Food Chem. 2008, 56, 4529-4533
11. Cabrera, C.; Artacho, R.; Giménez, R. Beneficial effects of green tea-a review J. Am. Coll. Nutr. 2006, 25, 79-99
12. Chen, H. X.; Zhang, M.; Qu, Z. S.; Xie, B. J. Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia sinensis) Food Chem. 2008, 106, 559-563
13. Zhou, X. L.; Wang, D. F.; Sun, P. N.; Bucheli, P.; Li, L.; Hou, Y. F.; Wang, J. F. Effects of soluble tea polysaccharides on hyperglycemia in alloxan-diabetic mice J. Agric. Food Chem. 2007, 55, 5523-5528
14. Monobe, M.; Ema, K.; Kato, F.; Maeda-Yamamoto, M. Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract J. Agric. Food Chem. 2008, 56, 1423-1427
15. Dubois, M.; Gilles, K. A.; Hamilton, J. K.; Rebers, P. A.; Smith, F. Colorimetric method for determination of sugars and related substances Anal. Chem. 1956, 28, 350-356
16. Bitter, T.; Muir, H. M. A modified uronic acid carbazole reaction Anal. Biochem. 1962, 4, 330-334
17. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 1976, 72, 248-254
18. Lv, Y.; Yang, X.; Ruan, Y.; Yang, Y.; Wang, Z. Separation and quantification of component monosaccharides of the tea polysaccharides from Gynostemma pentaphyllum by HPLC with indirect UV detection Food Chem. 2009, 112, 742-746
19. Shang, D. J.; Zhang, J. N.; Wen, L.; Li, Y.; Cui, Q. Preparation, characterization, and antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from Se-enriched Ganoderma lucidum J. Agric. Food Chem. 2009, 57, 7737-7742
20. Li, W. J.; Nie, S. P.; Chen, Y.; Wang, Y. X.; Li, C.; Xie, M. Y. Enhancement of cyclophosphamide-induced antitumor effect by a novel polysaccharide from Ganoderma atrum in sarcoma 180-bearing mice J. Agric. Food Chem. 2011, 59, 3707-3716
21. He, N.; Yang, X.; Jiao, Y.; Tian, L.; Zhao, Y. Characterisation of antioxidant and antiproliferative acidic polysaccharides from Chinese wolfberry fruits Food Chem. 2012, 133, 978-989
22. Hsu, Y. L.; Chen, C. Y.; Hou, M. F.; Tsai, E. M.; Jong, Y. J.; Hung, C. H.; Kuo, P. L. 6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells Mol. Nutr. Food Res. 2010, 54, 1307-1317
23. kip1/skp2 complex J. Agric. Food Chem. 2011, 59, 1996-2003
24. Huang, W. W.; Chiu, Y. J.; Fan, M. J.; Lu, H. F.; Yeh, H. F.; Li, K. H.; Chen, P. Y.; Chung, J. G.; Yang, J. S. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells Mol. Nutr. Food Res. 2010, 54, 1585-1595
25. Chou, C. C.; Yang, J. S.; Lu, H. F.; Ip, S. W.; Lo, C.; Wu, C. C.; Lin, J. P.; Tang, N. Y.; Chung, J. G.; Chou, M. J.; Teng, Y. H.; Chen, D. R. Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells Arch. Pharm. Res. 2010, 33, 1181-1191
26. Son, Y. O.; Hitron, J. A.; Wang, X.; Chang, Q. S.; Pan, J. J.; Zhang, Z.; Liu, J. K.; Wang, S. X.; Lee, J. C.; Shi, X. L. Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells Toxicol. Appl. Pharmacol. 2010, 245, 226-235
27. Juan, M. E.; Wenzel, U.; Daniel, H.; Planas, J. M. Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells J. Agric. Food Chem. 2008, 56, 4813-4818
28. Li, L.; Lu, N.; Dai, Q.; Wei, L.; Zhao, Q.; Li, Z.; He, Q.; Dai, Y.; Guo, Q. GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial- mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells Eur. J. Pharmacol. 2011, 670, 13-21
29. Zhang, H.; Zhang, M.; Yu, L.; Zhao, Y.; He, N.; Yang, X. B. Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines Food Chem. Toxicol. 2012, 50, 1589-1599
30. Van-Delft, M. F.; Huang, D. C. How the Bcl-2 family of proteins interact to regulate apoptosis Cell Res. 2006, 16, 203-213
31. Giono, L. E.; Manfredi, J. J. Mdm2 is required for inhibition of CDK2 activity by p21, thereby contributing to p53-dependent cell cycle arrest Mol. Cell. Biol. 2007, 27, 4166-4178
32. Satyanarayana, A.; Kaldis, P. A dual role of Cdk2 in DNA damage response Cell Div. 2009, 4, 9-12
33. Zhang, Y.; Luo, M.; Zu, Y.; Fu, Y.; Gu, C.; Wang, W.; Yao, L.; Efferth, T. Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway Chem.-Biol. Interact. 2012, 199, 129-136
34. Nangia-Makker, P.; Conklin, J.; Hogan, V.; Raz, A. Carbohydrate-binding proteins in cancer, and their ligands as therapeutic agents Trends Mol. Med. 2002, 8, 187-192
35. Siegel, R.; Naishadham, D.; Jemal, A. Cancer statistics, 2012 CA: Cancer J. Clin. 2012, 62, 10-29
36. Phil-Evans, W. Breast cancer screening: successes and challenges CA: Cancer J. Clin. 2012, 62, 5-9
37. Mitchell, D. B.; Santone, K. S.; Acosta, D. Evaluation of cytotoxicity in cultured cells by enzyme leakage Methods Cell Sci. 1980, 6, 113-116
38. Hafeez, B. B.; Siddiqui, I. A.; Asim, M.; Malik, A.; Afaq, F.; Adhami, V. M.; Saleem, M.; Din, M.; Mukhtar, H. A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-κB signaling Cancer Res. 2008, 68, 8564-8572
39. Chipuk, J. E.; Kuwana, T.; Bouchier-Hayes, L.; Droin, N. M.; Newmeyer, D. D.; Schuler, M.; Green, D. R. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Science 2004, 303, 1010-1014
40. EI-Deiry, W. S.; Harper, J. W.; O'Connor, P. M.; Velculescu, V. E.; Canman, C. E.; Jackman, J.; Pietenpol, J. A.; Burrell, M.; Hill, D. E.; Wang, Y.; Wiman, K. G.; Mercer, W. E.; Kastan, M. B.; Kohn, K. W.; Elledge, S. J.; Kinzler, K. W.; Vogelstein, B. WAF1 / CIP1 is induced in p53-mediated G1 arrest and apoptosis Cancer Res. 1994, 54, 1169-1174
41. Thornberry, N. A.; Lazebnik, Y. Caspases: enemies within Science 1998, 281, 1312-1316
42. Vaculova, A.; Zhivotovsky, B. Caspases: determination of their activities in apoptotic cells Methods Enzymol. 2008, 442, 157-181
43. Sreelatha, S.; Jeyachitra, A.; Padma, P. R. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells Food Chem. Toxicol. 2011, 49, 1270-1275
44. Gackowski, D.; Banaszkiewicz, Z.; Rozalski, R.; Jawien, A.; Olinski, R. Persistent oxidative stress in colorectal carcinoma patients Int. J. Cancer 2002, 101, 395-397
45. Lu, H. F.; Chen, Y. L.; Yang, J. S.; Yang, Y. Y.; Liu, J. Y.; Hsu, S. C.; Lai, K. C.; Chung, J. G. Antitumor activity of capsaicin on human colon cancer cells in vitro and Colo 205 tumor xenografts in vivo J. Agric. Food Chem. 2010, 58, 12999-13005