Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

Journal of Bone and Mineral Research

Volumn 28, Issue 1, 2013, Pages 81-91

  Kiffer Moreira, Tina ^a   Yadav, Manisha C ^a   Zhu, Dongxing ^b   Narisawa, Sonoko ^a   Sheen, Campbell ^a   Stec, Boguslaw ^a   Cosford, Nicholas D ^a   Dahl, Russell ^a   Farquharson, Colin ^b   Hoylaerts, Marc F ^c   MacRae, Vicky E ^b   Millán, José Luis ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

ALKALINE PHOSPHATASE; HIGH THROUGHPUT SCREENING; KINETIC STUDIES; PHARMACOLOGICAL INHIBITORS; SMALL MOLECULES

Indexed keywords

ALKALINE PHOSPHATASE; LANSOPRAZOLE; MLS 0038949; MLS 0315922; MLS 0390837; MLS 0390838; MLS 0390839; MLS 0437435001; MLS 0437436001; MLS 0437437001; MLS 0437438001; MLS 0437439001; PHOSPHATASE; PHOSPHO1 ENZYME; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; TISSUE NONSPECIFIC ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD VESSEL CALCIFICATION; BONE MINERALIZATION; CALCIFICATION; CELL CULTURE; CELL VIABILITY; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; GENE EXPRESSION; GENETIC ANALYSIS; HIGH THROUGHPUT SCREENING; IC 50; MEDIAL VASCULAR CALCIFICATION; MOLECULAR DOCKING; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE CELL; WILD TYPE;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ALKALINE PHOSPHATASE; ANIMALS; CALCIFICATION, PHYSIOLOGIC; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORIC MONOESTER HYDROLASES; RNA, MESSENGER; SUBSTRATE SPECIFICITY; VASCULAR CALCIFICATION;

EID: 84872842592     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1733     Document Type: Article

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