Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)

Journal of Medicinal Chemistry

Volumn 52, Issue 21, 2009, Pages 6919-6925

  Dahl, Russell ^a   Sergienko, Eduard A ^a   Su, Ying ^a   Mostofi, Yalda S ^a   Yang, Li ^a   Simao, Ana Maria ^a   Narisawa, Sonoko ^a   Brown, Brock ^a   Mangravita Novo, Arianna ^a   Vicchiarelli, Michael ^a   Smith, Layton H ^a   O'Neill, W Charles ^b   Millán, José Luis ^a   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXY 4 NITRO N (QUINOLIN 3 YL)BENZENESULFONAMIDE; 2 METHOXY 5 METHYL N (QUINOLIN 3 YL)BENZENESULDONAMIDE; 2,5 DIMETHOXY N (NAPHTHALEN 2 YL)BENZENESULFONAMIDE; 2,5 DIMETHOXY N (PYRIDIN 3 YL)BENZENESULFONAMIDE; 2,5 DIMETHOXY N (QUINOLIN 3 YL)BENZENESULFONAMIDE; 2,5 DIMETHOXY N (QUINOLIN 6 YL)BENZENESULFONAMIDE; 3 METHOXY N (QUINOLIN 3 YL)BENZENESULFONAMIDE; 5 BROMO 2 METHOXY N (QUINOLIN 3 YL)BENZENESULFONAMIDE; ALKALINE PHOSPHATASE; ENZYME INHIBITOR; N (2,5 DIMETHOXYPHENYL)QUINOLINE 3 SULFONAMIDE; SULFONAMIDE; TNAP ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIFICATION; CATALYSIS; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN;

ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL AVAILABILITY; CALCINOSIS; CATALYSIS; CERCOPITHECUS AETHIOPS; COS CELLS; MICROSOMES, LIVER; PERMEABILITY; QUINOLINES; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 71049131273     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900383s     Document Type: Article

References (15)

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