Plasma pyrophosphate and vascular calcification in chronic kidney disease

Nephrology Dialysis Transplantation

Volumn 25, Issue 1, 2010, Pages 187-191

  O'Neill, W Charles ^a   Sigrist, Mhairi K ^b   McIntyre, Christopher W ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Chronic kidney disease; End stage renal disease; Haemodialysis

Indexed keywords

PHOSPHATE; PYROPHOSPHATE;

ADULT; ARTICLE; BLOOD VESSEL CALCIFICATION; CHRONIC KIDNEY DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIALYSIS; ENZYME ASSAY; FEMALE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PERITONEAL DIALYSIS; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; SUPERFICIAL FEMORAL ARTERY;

AGED; CALCINOSIS; CHRONIC DISEASE; DIPHOSPHATES; FEMALE; FEMORAL ARTERY; HUMANS; KIDNEY DISEASES; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PERITONEAL DIALYSIS; RENAL DIALYSIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 72949101197     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp362     Document Type: Article

References (20)

1. Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 2001; 38: 938-942
2. Sigrist MK, Taal MW, Bungay P, McIntyre CW. Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in CKD 4 and 5 patients. Clin J Am.Soc.Nephrol 2007; 2: 1241-1248
3. Chertow GM, Burke SK, Raggi P. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 2002; 62: 245-252
4. Block GA, Spiegel DM, Ehrlich J et al. Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int 2005; 68: 1815-1824
5. Chertow GM, Raggi P, Chasan-Taber S et al. Determinants of progressive vascular calcification in haemodialysis patients. Nephrol Dial Transplant 2004; 19: 1489-1496
6. Stompor T, Pasowicz M, Sulowicz W et al. Trends and dynamics of changes in calcification score over the 1-year observation period in patients on peritoneal dialysis. Am J Kidney Dis 2004; 44: 517-528 (Pubitemid 39164628)
7. O'Neill WC. The fallacy of the calcium phosphorus product. Kidney Int 2007; 72: 792-796
8. Luo G, Ducy P, McKee MD et al. Spontaneous calcificationof arteries and cartilage in mice lacking matrix Gla protein. Nature 1997; 386: 78-81
9. Bucay N, Sarosi I, Dunstan C et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998; 12: 1260-1268
10. Rutsch F, Vaingankar S, Johnson K et al. PC-1 Nucleotide triphos-phate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol 2001; 158: 543-554
11. Meyer JL. Can biological calcification occur in the presence of py-rophosphate? Arch Biochem Biophys 1984; 231: 1-8
12. Lomashvili KA, Cobbs S, Hennigar RA, Hardcastle KI, O'Neill WC. Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin. J Am Soc Nephrol 2004; 15: 1392-1401
13. Lomashvili KA, Garg P, Narisawa S, Millan JL, O'Neill WC. Renal failure upregulates smooth muscle alkaline phosphatase and increases pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification. Kidney Int 2008; 73:1024-1030
14. Lomashvili KA, Khawandi W, O'Neill WC. Reduced plasma py-rophosphate levels in hemodialysis patients. J Am Soc Nephrol 2005; 16: 2495-2500
15. Sigrist MK, Bungay P, Taal MW, McIntyre CW. Vascular calcification and cardiovascular function in chronic kidney disease. Nephrol Dial Transplant 2006; 21: 707-714
16. Agatston AS, Janowitz WR, Hildner FJ et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Amer College Cardiol 1990; 15: 827-832
17. Silcox DC, McCarty DJ. Measurement of inorganic pyrophosphate in biologic fluids. Elevated levels in some patients with osteoarthritis, pseudogout, acromegaly, and uremia. J Clin Invest 1973; 52: 1863-1870
18. Coburn SP, Mahuren JD, Jain M, Zubovic Y, Wortsman J. Alkaline phosphatase (EC 3.1.3.1) in serum is inhibited by physiological concentrations of inorganic phosphate. J Clin Endocrinol Metab 1998; 83: 3951-3957
19. Rachow JW, Ryan LM. Inorganic pyrophosphate metabolism in arthritis. Rheumatic Disease Clinics of North America 1988; 14: 289-302
20. Farley RJ, Stilt-Coffing B. Apoptosis may determine the release of skeletal alkaline phosphatase activity from human osteoblast-line cells. Calcif Tissue Int 2001; 68: 43-52