Promoter scanning of the human COX-2 gene with 8-ring polyamides: Unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine

Biochimie

Volumn 95, Issue 2, 2013, Pages 271-279

  Bashkin, James K ^a   Aston, Karl ^a   Ramos, Joseph P ^b   Koeller, Kevin J ^a   Nanjunda, Rupesh ^b   He, Gaofei ^a   Dupureur, Cynthia M ^a   David Wilson, W ^b  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Capillary electrophoresis; DNA; Fluorescence spectroscopy; Footprinting; Polyamide; Surface plasmon resonance

Indexed keywords

BETA ALANINE; CYCLOOXYGENASE 2; POLYAMIDE; PYRROLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DNA CONFORMATION; DNA FOOTPRINTING; DNA HAIRPIN; DNA SEQUENCE; HUMAN; HYDROGEN BOND; ISOTHERM; MOLECULAR DOCKING; MOLECULAR RECOGNITION; PROMOTER REGION; PROTEIN DNA BINDING; SURFACE PLASMON RESONANCE;

BASE SEQUENCE; BETA-ALANINE; CYCLOOXYGENASE 2; DNA; DNA FOOTPRINTING; HUMAN PAPILLOMAVIRUS 16; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INVERTED REPEAT SEQUENCES; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; NYLONS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEIN C-ETS-1; PYRROLES; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

ANIMALIA;

EID: 84872816487     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.09.023     Document Type: Article

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