Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides

EMBO Journal

Volumn 20, Issue 12, 2001, Pages 3218-3228

  Maeshima, K ^a   Janssen, S ^a   Laemmli, U K ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

DNA minor groove; DNA sequence specific polyamides; Telomeres; TRF1

Indexed keywords

IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE; TH 52B; TH 59; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; INSECT; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TANDEM REPEAT; TELOMERE; VERTEBRATE;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; FLUORESCENCE; HELA CELLS; HUMANS; IMIDAZOLES; NYLONS; PYRROLES; REPETITIVE SEQUENCES, NUCLEIC ACID; SPODOPTERA; STAINING AND LABELING; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1;

INSECTA; VERTEBRATA;

EID: 0035875667     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.12.3218     Document Type: Article

References (32)

1. Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids
2. Telomere states and cell fates
3. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
4. Design of a G·C-specific DNA minor groove-binding peptide
5. In vivo analysis of scaffold-associated regions in Drosophila: A synthetic high-affinity SAR binding protein suppresses position effect variegation
6. Mammalian telomeres end in a large duplex loop
7. Facilitation of chromatin dynamics by SARs
8. The DNA sequence of human chromosome 21. The chromosome 21 mapping and sequencing consortium
9. Tandem hairpin motif for recognition in the minor groove of DNA by pyrrole-imidazole polyamides
10. Telomere analysis by fluorescence in situ hybridization and flow cytometry
11. Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster
12. Chromatin opening of DNA satellites by targeted sequence-specific drugs
13. Structural effects of DNA sequence on T·A recognition by hydroxypyrrole/pyrrole pairs in the minor groove
14. Cytogenetic methods for the mouse: Preparation of chromosomes, karyotyping and in situ hybridization
15. Telomeres and their control
16. n among vertebrates
17. n, in the silkworm Bombyx mori and in other insects
18. Telomerases
19. Telomeres, telomerase and cancer: Life on the edge of genomic stability
20. Telomerase: Dr Jekyll or Mr Hyde?
21. TTAGG telomeric repeats in chromosomes of some insects and other arthropods
22. Metaphase chromosome structure: Bands arise from a differential folding path of the highly AT-rich scaffold
23. Control of human telomere length by TRF1 and TRF2
24. SARs are cis DNA elements of chromosome dynamics: Synthesis of a SAR repressor protein
25. Recognition of a 5′-(A, T)GGG(A, T)2-3′ sequence in the minor groove of DNA by an eight-ring hairpin polyamide
26. Effects of γ-turn and β-tail amino acids on sequence specific recognition of DNA by hairpin polyamides
27. Control of telomere length by the human telomeric protein TRF1
28. The establishment of two cell lines from the insect Spodoptera frugiperda (Lepidoptera; Noctuidae)
29. Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methyl-imidazole -2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA
30. Designed sequence-specific minor groove ligands
31. On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides
32. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats