2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6- dihydrothieno[2,3-h] quinoline derivatives for topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Bioorganic Chemistry

Volumn 40, Issue 1, 2012, Pages 67-78

  Thapa, Pritam ^a   Karki, Radha ^a   Yoo, Han Young ^a   Park, Pil Hoon ^a   Lee, Eunyoung ^b   Jeon, Kyung Hwa ^b   Na, Younghwa ^c   Cho, Won Jea ^d   Kwon, Youngjoo ^b   Lee, Eung Seok ^a  

^a Yeungnam University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Cha University   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

2,4 Diaryl 5,6 dihydrothieno 2,3 h quinoline; 2,4 Diaryl 5,6 dihydro 1,10 phenanthroline; Cytotoxicity; Terpyridine; Topoisomerase I and II

Indexed keywords

2 (PYRIDIN 2 YL) 4 (PYRIDIN 3 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2 (PYRIDIN 2 YL) 4 (PYRIDIN 4 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2 (PYRIDIN 3 YL) 4 (PYRIDIN 4 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2 PHENYL 4 (PYRIDIN 2 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2 PHENYL 4 (PYRIDIN 3 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2 PHENYL 4 (PYRIDIN 4 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2,4 DI(PYRIDIN 2 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2,4 DI(PYRIDIN 2 YL) 5,6 DIHYDROTHIENO[2,3 H]QUINOLINE; 2,4 DI(PYRIDIN 3 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 2,4 DI(PYRIDIN 4 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 4 (PYRIDIN 2 YL) 2 (PYRIDIN 3 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 4 (PYRIDIN 2 YL) 2 (PYRIDIN 3 YL) 5,6 DIHYDROTHIENO[2,3 H]QUINOLINE; 4 (PYRIDIN 2 YL) 2 (PYRIDIN 4 YL) 5,6 DIHYDRO 1,10; 4 (PYRIDIN 3 YL) 2 (PYRIDIN 4 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 4 PHENYL 2 (PYRIDIN 2 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 4 PHENYL 2 (PYRIDIN 3 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 4 PHENYL 2 (PYRIDIN 4 YL) 5,6 DIHYDRO 1,10 PHENANTHROLINE; 5 (PYRIDIN 2 YLMETHYLENE) 6,7 DIHYDROBENZO[B]THIOPHEN 4 (5H )ONE; 5 (PYRIDIN 3 YLMETHYLENE) 6,7 DIHYDROBENZO[B]THIOPHEN 4 (5H)ONE; 5 (PYRIDIN 4 YLMETHYLENE) 6,7 DIHYDROBENZO[B]THIOPHEN 4 (5H)ONE; 5 BENZYLIDENE 6,7 DIHYDROBENZO[B]THIOPHEN 4 (5H)ONE; 7 (PYRIDIN 2 YLMETHYLENE) 6,7 DIHYDROQUINOLIN 8 (5H)ONE; 7 (PYRIDIN 3 YLMETHYLENE) 6,7 DIHYDROQUINOLIN 8 (5H)ONE; 7 (PYRIDIN 4 YLMETHYLENE) 6,7 DIHYDROQUINOLIN 8 (5H)ONE; 7 BENZYLIDENE 6,7 DIHYDROQUINOLIN 8 (5H)ONE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); PHENANTHROLINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; PHENANTHROLINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84855895038     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2011.09.001     Document Type: Article

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