Cytotoxic effects of new trans-2,4-diaryl-r-3-methyl-1,2,3,4- tetrahydroquinolines and their interaction with antitumoral drugs gemcitabine and paclitaxel on cellular lines of human breast cancer

Chemico-Biological Interactions

Volumn 189, Issue 3, 2011, Pages 215-221

  Muñoz, Arturo ^a   Sojo, Felipe ^b   Arenas, Diego R Merchan ^c   Kouznetsov, Vladimir V ^c   Arvelo, Francisco ^a,b  

^a FACULTAD DE CIENCIAS   (Venezuela)

^b Fundacion Instituto de Estudios Avanzados IDEA   (Venezuela)

^c UNIVERSIDAD INDUSTRIAL DE SANTANDER   (Colombia)

Author keywords

Adjuvant therapy; Breast cancer; Synergism; Tetrahydroquinolines

Indexed keywords

2,4 DIARYL 3 METHYL 1,2,3,4 TETRAHYDROQUINOLINE DERIVATIVE; 8 NITRO 4 (4 HYDROXY 3 METHOXYPHENYL) 3 METHYL 2 (2 NITROPHENYL) 1,2,3,4 TETRAHYDROQUINOLINE; 8 NITRO 4 (4 HYDROXY 3 METHOXYPHENYL) 3 METHYL 2 PHENYL 1,2,3,4 TETRAHYDROQUINOLINE; ANTINEOPLASTIC AGENT; GEMCITABINE; PACLITAXEL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CELL GROWTH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DEOXYCYTIDINE; DRUG INTERACTIONS; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; FEMALE; HUMANS; PACLITAXEL; QUINOLINES;

EID: 79551558431     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.11.010     Document Type: Article

References (29)

1. F. Bray, R. Sankila, J. Ferlay, and D.M. Parkin Estimates of cancer incidence and mortality in Europe in 1995 Eur. J. Cancer 38 2002 99 166
2. C. Mettlin Global breast cancer mortality statistics CA Cancer J. Clin. 49 1999 138 144
3. P.A. Greenberg, G.N. Hortobagy, T.L. Smith, L.D. Ziegler, D.K. Frie, and A.U. Buzdar Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer J. Clin. Oncol. 14 1996 2197 2205
4. G. Falkson, D.C. Tormey, P. Carey, R. Witte, and H.C. Falkson Long-term survival of patients treated with combination chemotherapy for metastatic breast cancer Eur. J. Cancer 27 1991 973 977
5. J.R. Kroep, G. Giaccone, C. Tolis, D.A. Voorn, W.J. Loves, C.J. Groeninger, H.M. Pinedo, and G.J. Peters Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines Br. J. Cancer 83 2000 1069 1076
6. J. Carmichael The role of gemcitabine in the treatment of other tumours Br. J. Cancer 78 Suppl. 3 1998 21 25
7. I. Jacquemond-Collet, F. Benoit, C. Mustofa, A. Valentin, E. Stanislas, M. Mallié, and I. Fourasté Antiplasmodial and cytotoxic activity of galipinine and other tetrahydroquinolines from Galipea officinalis Planta Med. 68 2002 68 69
8. O. Wallace, K. Lauwers, S. Jones, and J. Dodge Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs) Bioorg. Med. Chem. Lett. 13 2003 1907 1910
9. G. Dorey, B. Lockhart, P. Lestage, and P. Casara New quinolinic derivatives as centrally active antioxidants Bioorg. Med. Chem. Lett. 10 2000 935 939
10. S. Vangapandu, M. Jain, S. Kaur, and P. Singh Ring-substituted quinolines as potential anti-tuberculosis agents Bioorg. Med. Chem. 12 2004 2501 2508
11. V. Monga, A. Nayyar, B. Vaitilingam, P. Palde, S. Jhamb, S. Kaur, and P. Singh Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues Bioorg. Med. Chem. 12 2004 6465 6472
12. M. Khan Quinoline analogs as antiangiogenic agents and telomerase inhibitors Top. Heterocycl. Chem. 11 2007 213 229
13. J. Isaacs, R. Pili, D. Qian, S. Dalrymple, J. Garrison, N. Kyprianou, and A. Björk Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer Prostate 66 2006 1768 1778
14. V. Caprio, B. Guyen, Y. Opoku-Boahen, J. Mann, S. Gowan, L. Kelland, M. Read, and S. Neidle A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline Bioorg. Med. Chem. Lett. 10 2000 2063 2066
15. V.V. Kouznetsov, D.R. Merchan Arenas, F. Arvelo, J.S. Bello Forero, F. Sojo, and A. Muñoz New 4-hydroxy-3-methoxyphenyl substituted 3-methyl-tetrahydroquinoline derivatives as potential antitumoral agents obtained through imino Diels-Alder reactions Lett. Drug Design Discov. 7 2010 632 639
16. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay J. Inmunol. Methods 65 1983 55 63
17. D. Callacondo, A. Quispe, S. Lindo, and A. Vaisberg Actividad citotóxica del extracto etanólico de Gnaphalium spicatum "Keto Keto" en cultivos de líneas celulares tumorales humanas Rev. Peru Med. Exp. Salud Pública 25 2008 380 385
18. P.K. Gessner Isobolographic analysis of interactions: an update on applications and utility Toxicology 105 1995 161 179
19. T.C. Chou, and P. Talalay Analysis of combined drug effects: a new look at a very old problem Trends Pharmacol. Sci. 4 1983 445 450
20. T.C. Chou, and P. Talalay Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv. Enzyme Regul. 22 1984 27 55
21. J.C. Chou Quantitation of synergism and antagonism of two or more drug by computerized analysis T.C. Chou, D.C. Rideout, Synergism and Antagonism in Chemotherapy 1991 Academic Press New York 223 244
22. T.C. Chou, and N. Martin A computer program for quantitation of synergism and antagonism in drug combinations, and the determination of IC50 and ED50 and LD50 values CompuSyn for Drug Combinations: PC Software and User's Guide 2005 ComboSyn Paramus, NJ
23. G.J. Peters, C.L. Van Der Wilt, C.J. Van Moorsel, J.R. Kroep, A.M. Bergman, and S.P. Ackland Basis for effective combination cancer chemotherapy with antimetabolites Pharmacol. Therap. 87 2000 227 253
24. M.V. Blagosklonny, J. Toretsky, and L. Weckers Geldanamycin selectively destabilizes and conformationally alters mutated p53 Oncogene 11 1995 933 939
25. J. Kovach, R. McGovern, I. Cassady, S. Swason, L. Wald, B. Vogelsteim, and S. Sommer Direct sequencing from touch preparations carcinomas: analysis of p53 mutation in breast carcinomas J. Natl. Cancer Inst. 83 1991 1004 1009
26. J. Cossman, and R. Schlegel p53 in the diagnosis of human neoplasia J. Natl. Cancer Inst. 83 1991 980 981
27. I. Tamm, F. Schriever, and B. Dörken Apoptosis: implications of basic research for clinical oncology Lancet 2 2001 33 42
28. Q. Li, S. Peng, Z. Sheng, and Y. Wan Ofloxacin induce oxidative damage to join chondrocytes of juvenile rabbits: excessive production of reactive oxygen species, lipid peroxidation and DNA damage Eur. J. Pharmacol. 626 2010 146 153
29. U. Ghosh, and N. Bhattacharyya Benzamide and 4-amino 1,8 naphthalamide treatment inhibe telomerase activity by down-regulation the expression of telomerase associated protein and inhibiting the poly ADP-ribosylation of telomerase reverse transcriptase in cultured cells FEBS J. 272 2005 4237 4424