Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats

Pharmacological Research

Volumn 42, Issue 4, 2000, Pages 361-371

  Jang, Yoon Young ^a   Song, Jin Ho ^a   Shin, Yong Kyoo ^a   Han, Eun Sook ^a   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

Author keywords

Boldine; Oxidative mitochondrial damage; Protective effect; Streptozotocin

Indexed keywords

ANTIOXIDANT; BOLDINE; DRINKING WATER; FREE RADICAL; GLUTATHIONE PEROXIDASE; HYDROXYL RADICAL; MALONALDEHYDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; LIPID PEROXIDATION; LIVER; LIVER MITOCHONDRION; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TISSUE INJURY;

PEUMUS BOLDUS;

EID: 0033806188     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2000.0705     Document Type: Article

References (56)

1. Role of oxidative stress in development of complications in diabetes
2. Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM
3. Sitespecific and random fragmentation of Cu, Zn-superoxide dismutase by glycation reaction. Implication of reactive oxygen species
4. Role of oxidative stress in diabetic complication: A new perspective on an old paradigm
5. Free radicals and diabetes
6. Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes
7. Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: New insights on the pathophysiological mechanisms of diabetic vascular complications
8. Defects at center p underlie diabetes-associated mitochondrial dysfunction
9. Hydroxyl radical formation in diabetic rats induced by streptozotocin
10. 2 generation and DNA fragmentation in pancreatic islets
11. The inhibition of islet superoxide dismutase by diabetogenic drugs
12. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells
13. Superoxide dismutase reduces islet microvascular injury induced by streptozotocin in the rat
14. Streptozotocin and alloxan induce DNA strand breaks and alloxan and poly (ATPribose) synthetase in pancreatic islets
15. Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
16. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells
17. Generation of nitric oxide from STZ in the presence of copper (II) plus ascorbate: Implication for the development of STZ induced DM
18. Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice
19. The use of aminoguanidine, a selective iNOS inhibitor, to evaluate the role of nitric oxide in the development of autoimmune diabetes
20. N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA, break formation in pancreatic rat islets
21. Peumus boldus Mol
22. Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation
23. Inhibition of rat liver microsomal lipid peroxidation by boldine
24. Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo
25. Genotoxicity of the boldine aporphine alkaloid in prokaryotic and eukaryotic organisms
26. In vitro interaction of NSAID on oxidative phosphorylation of rat kidney mitochondria
27. 2+ in pancreas and adrenal cortex mitochondria
28. Microsomal lipid peroxidation: Biomembranes
29. Determination of carbonyl content in oxidatively modified proteins
30. Zinc as an inducer of the membrane permeability transition in rat liver mitochondria
31. Mitochondrial superoxide simultase. Site of synthesis and intramitochondrial localization
32. MPTP produces differential oxidative stress and antioxidative responses in the nigrostriatal and mesolimbic dopaminergic pathways
33. Nitric oxide generation mediates lipid A-induced oxidant injury in renal proximal tubules
34. Oxidant/antioxidant balance in isolated glomeruli and cultured mesangial cells
35. Formation of a thiobarbituric acidreactive substance from deoxyribose in the presence of iron salts. The role of superoxide and hydroxyl radicals
36. Chemistry of dioxygen
37. Nitric oxide synthase assays
38. Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: Role of inhibition of NFκB activation
39. Expression of the inducible NO synthase in human monocytic U937 cells allows high output nitric oxide production
40. Deoxyribose assay for detecting hydroxyl radicals
41. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats
42. Anti-inflammatory and antipyretic effects of boldine
43. Boldine prevents human liver microsomal lipid peroxidation an inactivation of cytochrome P4502E1
44. Inhibitory effects of boldine on fish oil oxidation
45. Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes
46. The role of oxidative stress and antioxidant treatment in experimental diabetic neuropathy
47. Pharmacological actions of melatonin in oxygen radical pathophysiology
48. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose
49. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment
50. Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice
51. Antioxidant defense system in diabetic kidney: A time course study
52. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
53. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases
54. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
55. Oxidant mechanisms in toxic acute renal failure
56. Production of nitric oxide by mitochondria