Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin

Virchows Archiv

Volumn 444, Issue 4, 2004, Pages 375-382

  Wada, Ryuichi ^a   Yagihashi, Soroku ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Beta cell; Cell death; Nitric oxide; Poly(ADP ribose); Polymerase; Streptozotocin

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; ACETOACETIC ACID; DICHLOROFLUORESCEIN; FREE RADICAL; N(G) NITROARGININE METHYL ESTER; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; SCAVENGER; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL MIGRATION; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVATION; FLUORESCENCE; MACROPHAGE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; CELL MOVEMENT; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; ENZYME INHIBITORS; FREE RADICALS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; ISLETS OF LANGERHANS; MACROPHAGES; MALE; NITRIC OXIDE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; STREPTOZOCIN; TIME FACTORS;

EID: 2142660740     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-003-0967-z     Document Type: Article

References (25)

1. Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, Maeda H (1993) Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32:827-832
2. Anderson T, Schein PS, McMenamin MG, Cooney DA (1974) Correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide. J Clin Invest 54:672-677
3. Boer R, Ulrich WR, Klein T, Mirau B, Haas S, Baur I (2000) The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol 58:1026-1034
4. Brosky G, Logothetopoulos J (1969) Streptozotocin diabetes in the mouse and guinea pig. Diabetes 18:606-611
5. Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H (1999) Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med 5:314-319
6. Eizirik DL, Sandler S, Sener A, Malaisse WJ (1988) Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure. Endocrinology 123:1001-1007
7. Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S (2000) Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia 43:1528-1533
8. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y (2000) A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med 342:301-307
9. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y (2000) A proposal of three distinct subtypes of type 1 diabetes mellitus based on clinical and pathological evidence. Ann Med 32:539-543
10. Junod A, Lambert AE, Orci L, Pictet R, Gonet AE, Renold AE (1967) Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med 126:201-205
11. Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T, Nakamura M, Tatsumi H, Yamasaki Y, Kamada T, Taniguchi N (1995) Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes 44:733-738
12. Kroncke KD, Fehsel K, Sommer A, Rodriguez ML, Kolb-Bachofen V (1995) Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage. Biol Chem Hoppe Seyler 376:179-185
13. Kwon NS, Lee SH, Choi CS, Kho T, Lee HS (1994) Nitric oxide generation from streptozotocin. FASEB J 8:529-533
14. Masutani M, Suzuki H, Kamada N, Watanabe M, Ueda O, Nozaki T, Jishage K, Watanabe T, Sugimoto T, Nakagama H, Ochiya T, Sugimura T (1999) Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A 96:2301-2304
15. Papaccio G, Pisanti FA, Latronico MV, Ammendola E, Galdieri M (2000) Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide. J Cell Biochem 77:82-91
16. Satoh MS, Lindahl T (1992) Role of poly(ADP-ribose) formation in DNA repair. Nature 356:356-358
17. Suematsu M, Suzuki H, Ishii H, Kato S, Yanagisawa T, Asako H, Suzuki M, Tsuchiya M (1992) Early midzonal oxidative stress preceding cell death in hypoperfused rat liver. Gastroenterology 103:994-1001
18. Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50:537-546
19. Turk J, Corbett JA, Ramanadham S, Bohrer A, McDaniel ML (1993) Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem Biophys Res Commun 197:1458-1464
20. Uchigata Y, Yamamoto H, Nagai H, Okamoto H (1983) Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis. Diabetes 32:316-318
21. Wang H, Joseph JA (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616
22. West E, Simon OR, Morrison EY (1996) Streptozotocin alters pancreatic beta-cell responsiveness to glucose within six hours of injection into rats. West Indian Med J 45:60-62
23. Yamagami T, Miwa A, Takasawa S, Yamamoto H, Okamoto H (1985) Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res 45:1845-1849
24. Yamamoto H, Uchigata Y, Okamoto H (1981) DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin. Biochem Biophys Res Commun 103:1014-1020
25. Yamamoto H, Uchigata Y, Okamoto H (1981) Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets. Nature 294:284-286