Tolerance induction strategies in vascularized composite allotransplantation: Mixed chimerism and novel developments

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Leonard, David A ^a,b   McGrouther, Duncan A ^b   Kurtz, Josef M ^a,c   Cetrulo, Curtis L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c EMMANUEL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

ALLOTRANSPLANTATION; ARTERIOSCLEROSIS; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL THERAPY; CHIMERA; DENDRITIC CELL; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HUMAN; IMMUNE RESPONSE; MESENCHYMAL STEM CELL; MORBIDITY; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SKIN TRANSPLANTATION; TRANSPLANTATION TOLERANCE; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION; ANIMAL; IMMUNOLOGY;

ANIMALS; HUMANS; TRANSPLANTATION CHIMERA; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

MLCS; MLOWN;

EID: 84872793486     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/863264     Document Type: Review

References (79)

1. Gibson T., Medawar P. B., The fate of skin homografts in man. Journal of Anatomy 1943 77 299 310
2. Siemionow M., Klimczak A., Advances in the development of experimental composite tissue transplantation models. Transplant International 2010 23 1 2 13 2-s2.0-70949085304 10.1111/j.1432-2277.2009.00948.x
3. Morelon E., Kanitakis J., Petruzzo P., Immunological issues in clinical composite tissue allotransplantation: where do we stand today? Transplantation 2012 93 9 855 859 10.1097/TP.0b013e31824728b8
4. Kouwenhoven E. A., IJzermans J. N. M., de Bruin R. W. F., Etiology and pathophysiology of chronic transplant dysfunction. Transplant International 2000 13 6 385 401 2-s2.0-0033637051 10.1007/s001470050721
5. Petruzzo P., Kanitakis J., Badet L., Pialat J. B., Boutroy S., Charpulat R., Mouly J., Gazarian A., Lanzetta M., Brunet M., Devauchelle B., Testelin S., Martin X., Dubernard J. M., Morelon E., Long-term follow-up in composite tissue allotransplantation: in-depth study of five (hand and face) recipients. American Journal of Transplantation 2011 11 4 808 816 2-s2.0-79953234388 10.1111/j.1600-6143.2011.03469.x
6. Gorantla V. S., Demetris A. J., Acute and chronic rejection in upper extremity transplantation: what have we learned? Hand Clinics 2011 27 4 481 493 10.1016/j.hcl.2011.08.006
7. Sachs D. H., Tolerance: of mice and men. Journal of Clinical Investigation 2003 111 12 1819 1821 2-s2.0-0041743160 10.1172/JCI200318926 (Pubitemid 38057726)
8. Pilat N., Hock K., Wekerle T., Mixed chimerism through donor bone marrow transplantation: a tolerogenic cell therapy for application in organ transplantation. Current Opinion in Organ Transplantation 2012 17 1 63 70 10.1097/MOT.0b013e32834ee68b
9. Owen R. D., Immunogenetic consequences of vascular anastomoses between bovine twins. Science 1945 102 2651 400 401 2-s2.0-0000658958
10. Sykes M., Sachs D. H., Mixed chimerism. Philosophical Transactions of the Royal Society of London. Series B 2001 356 1409 707 726 (Pubitemid 32575703)
11. Ildstad S. T., Wren S. M., Bluestone J. A., Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. Journal of Experimental Medicine 1985 162 1 231 244 2-s2.0-0021845739 (Pubitemid 15029899)
12. Sykes M., Mixed chimerism and transplant tolerance. Immunity 2001 14 4 417 424 2-s2.0-0035025762 10.1016/S1074-7613(01)00122-4 (Pubitemid 32441594)
13. Pilat N., Wekerle T., Transplantation tolerance through mixed chimerism. Nature Reviews Nephrology 2010 6 10 594 605 2-s2.0-77957576120 10.1038/nrneph.2010.110
14. Ildstad S. T., Sachs D. H., Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of alllografts or xenografts. Nature 1984 307 5947 168 170 2-s2.0-0021251825 (Pubitemid 14132903)
15. Sharabi Y., Sachs D. H., Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. Journal of Experimental Medicine 1989 169 2 493 502 2-s2.0-0024561069 (Pubitemid 19050646)
16. Huang C. A., Fuchimoto Y., Scheier-Dolberg R., Murphy M. C., Neville D. M., Sachs D. H., Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model. Journal of Clinical Investigation 2000 105 2 173 181 2-s2.0-0033966351 (Pubitemid 30054356)
17. Spitzer T. R., Delmonico F., Tolkoff-Rubin N., McAfee S., Sackstein R., Saidman S., Colby C., Sykes M., Sachs D. H., Cosimi A. B., Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999 68 4 480 484 2-s2.0-0032852141 10.1097/00007890-199908270- 00006 (Pubitemid 29416620)
18. Wekerle T., Kurtz J., Sayegh M. H., Ito H., Wells A. D., Bensinger S., Shaffer J., Turka L. A., Sykes M., Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. Journal of Immunology 2001 166 4 2311 2316 2-s2.0-0035865066 (Pubitemid 32173463)
19. Domenig C., Sanchez-Fueyo A., Kurtz J., Alexopoulos S. P., Mariat C., Sykes M., Strom T. B., Zheng X. X., Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. Journal of Immunology 2005 175 1 51 60 2-s2.0-21244483043 (Pubitemid 40884301)
20. + cells. American Journal of Transplantation 2001 1 4 339 349 2-s2.0-0035502524 10.1034/j.1600-6143.2001.10409.x (Pubitemid 33681698)
21. Kurtz J., Wekerle T., Sykes M., Tolerance in mixed chimerism: a role for regulatory cells? Trends in Immunology 2004 25 10 518 523 2-s2.0-19344373375 10.1016/j.it.2004.08.007 (Pubitemid 39208349)
22. Wekerle T., Kurtz J., Ito H., Ronquillo J. V., Dong V., Zhao G., Shaffer J., Sayegh M. H., Sykes M., Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nature Medicine 2000 6 4 464 469 2-s2.0-0034071426 10.1038/74731 (Pubitemid 30208167)
23. Wekerle T., Sayegh M. H., Hill J., Zhao Y., Chandraker A., Swenson K. G., Zhao G., Sykes M., Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. Journal of Experimental Medicine 1998 187 12 2037 2044 2-s2.0-0032526283 10.1084/jem.187.12.2037 (Pubitemid 28285573)
24. Kawai T., Cosimi A. B., Colvin R. B., Powelson J., Eason J., Kozlowski T., Sykes M., Monroy R., Tanaka M., Sachs D. H., Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995 59 2 256 262 2-s2.0-0028860210
25. Kawai T., Cosimi A. B., Spitzer T. R., Tolkoff-Rubin N., Suthanthiran M., Saidman S. L., Shaffer J., Preffer F. I., Ding R., Sharma V., Fishman J. A., Dey B., Ko D. S. C., Hertl M., Goes N. B., Wong W., Williams W. W., Colvin R. B., Sykes M., Sachs D. H., HLA-mismatched renal transplantation without maintenance immunosuppression. The New England Journal of Medicine 2008 358 4 353 361 2-s2.0-38549088096 10.1056/NEJMoa071074 (Pubitemid 351159234)
26. Leventhal J., Abecassis M., Miller J., Gallon L., Ravindra K., Tollerud D. J., King B., Elliott M. J., Herzig G., Herzig R., Ildstad S. T., Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Science Translational Medicine 2012 4 124 10.1126/scitranslmed.3003509 124ra28
27. Mathes D. W., Randolph M. A., Solari M. G., Nazzal J. A., Nielsen G. P., Arn J. S., Sachs D. H., Lee W. P. A., Split tolerance to a composite tissue allograft in a swine model. Transplantation 2003 75 1 25 31 2-s2.0-0037439805 10.1097/00007890-200301150-00005 (Pubitemid 36139690)
28. Hettiaratchy S., Melendy E., Randolph M. A., Coburn R. C., Neville D. M., Sachs D. H., Huang C. A., Lee W. P. A., Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation 2004 77 4 514 521 2-s2.0-1442360359 10.1097/01.TP.0000113806. 52063.42 (Pubitemid 38282804)
29. Horner B. M., Randolph M. A., Duran-Struuck R., Hirsh E. L., Ferguson K. K., Teague A. G. S., Butler P. E. M., Huang C. A., Induction of tolerance to an allogeneic skin flap transplant in a preclinical large animal model. Transplantation Proceedings 2009 41 2 539 541 2-s2.0-62849100443 10.1016/j.transproceed.2009.01.015
30. Murray J. E., Organ transplantation (skin, kidney, heart) and the plastic surgeon. Plastic and Reconstructive Surgery 1971 47 5 425 431 2-s2.0-0015057180
31. Lee W. P. A., Rubin J. P., Bourget J. L., Cober S. R., Randolph M. A., Nielsen G. P., Ierino F. L., Sachs D. H., Tolerance to limb tissue allografts between swine matched for major histocompatibility complex antigens. Plastic and Reconstructive Surgery 2001 107 6 1482 1490 2-s2.0-0035029154 (Pubitemid 32374056)
32. Billingham R. E., Silvers W. K., The induction of tolerance of skin homografts in rats with pooled cells from multiple donors. Journal of Immunology 1959 83 667 679 2-s2.0-33645180622
33. Horner B. M., Randolph M. A., Huang C. A., Butler P. E. M., Skin tolerance: in search of the Holy Grail. Transplant International 2008 21 2 101 112 2-s2.0-38049129287 10.1111/j.1432-2277.2007.00559.x
34. Steinmuller D., The enigma of skin allograft rejection. Transplantation Reviews 1998 12 1 42 57 2-s2.0-0003029748 (Pubitemid 128654154)
35. Perloff L. J., Barker C. F., The immediately vascularized skin allograft. Transplantation 1979 28 2 125 130 2-s2.0-0018649589 (Pubitemid 9247281)
36. Wood K., Sachs D. H., Chimerism and transplantation tolerance: cause and effect. Immunology Today 1996 17 12 584 587 2-s2.0-0030459036 10.1016/S0167-5699(96)10069-4 (Pubitemid 26423424)
37. Elwood E. T., Larsen C. P., Maurer D. H., Routenberg K. L., Neylan J. F., Whelchel J. D., O'Brien D. P., Pearson T. C., Microchimerism and rejection in clinical transplantation. The Lancet 1997 349 9062 1358 1360 2-s2.0-0030962608 10.1016/S0140-6736(96)09105-2 (Pubitemid 27197538)
38. Mathes D. W., Hwang B., Graves S. S., Edwards J., Chang J., Storer B. E., Butts-Miwongtum T., Sale G. E., Nash R. A., Storb R., Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras. Transplantation 2011 92 12 1301 1308
39. Kilshaw P. J., Brent L., Pinto M., Suppressor T cells in mice made unresponsive to skin allografts. Nature 1975 255 5508 489 491 2-s2.0-0016812372
40. Gershon R. K., Liebhaber S., Ryu S., T cell regulation of T cell responses to antigen. Immunology 1974 26 5 909 923 2-s2.0-0016343081
41. + regulatory T cells in the human immune system. Nature Reviews Immunology 2010 10 7 490 500 2-s2.0-77954141914 10.1038/nri2785
42. + regulatory T lymphocytes. Nature Medicine 2008 14 1 88 92 2-s2.0-38049020656 10.1038/nm1688
43. + T lymphocytes. Blood 2004 103 11 4216 4221 2-s2.0-2542496868 10.1182/blood-2004-01-0005 (Pubitemid 38685366)
44. Bigenzahn S., Blaha P., Koporc Z., Pree I., Selzer E., Bergmeister H., Wrba F., Heusser C., Wagner K., Muehlbacher F., Wekerle T., The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. American Journal of Transplantation 2005 5 6 1237 1247 2-s2.0-20544457031 10.1111/j.1600-6143.2005.00862.x (Pubitemid 40839411)
45. Pilat N., Baranyi U., Klaus C., Jaeckel E., Mpofu N., Wrba F., Golshayan D., Muehlbacher F., Wekerle T., Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. American Journal of Transplantation 2010 10 4 751 762 2-s2.0-77949852097 10.1111/j.1600-6143. 2010.03018.x
46. + regulatory T cells. Blood 2005 105 12 4743 4748 2-s2.0-20444373376 10.1182/blood-2004-10-3932 (Pubitemid 40807298)
47. Issa F., Hester J., Goto R., Nadig S. N., Goodacre T. E., Wood K., Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010 90 12 1321 1327 2-s2.0-78650835204 10.1097/TP.0b013e3181ff8772
48. + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. Journal of Experimental Medicine 2002 196 3 389 399 2-s2.0-0037025943 10.1084/jem.20020399 (Pubitemid 34875667)
49. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002 99 10 3493 3499 2-s2.0-0037093217 10.1182/blood.V99.10.3493 (Pubitemid 34534513)
50. Steinman R. M., The control of immunity and tolerance by dendritic cells. Pathologie Biologie 2003 51 2 59 60 2-s2.0-0037357579 10.1016/S0369-8114(03) 00096-8 (Pubitemid 36427570)
51. Morelli A. E., Thomson A. W., Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunological Reviews 2003 196 125 146 2-s2.0-0344984407 10.1046/j.1600-065X.2003.00079.x (Pubitemid 37468108)
52. + T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. Journal of Immunology 2004 172 7 4100 4110 2-s2.0-1642396607 (Pubitemid 38375222)
53. + regulatory cell activation and function by dendritic cells. International Immunology 2004 16 12 1769 1780 2-s2.0-10844252294 10.1093/intimm/dxh178 (Pubitemid 40003865)
54. Barratt-Boyes S. M., Thomson A. W., Dendritic cells: tools and targets for transplant tolerance. American Journal of Transplantation 2005 5 12 2807 2813 2-s2.0-33644818052 10.1111/j.1600-6143.2005.01116.x (Pubitemid 43923940)
55. Grohmann U., Bianchi R., Orabona C., Fallarino F., Vacca C., Micheletti A., Fioretti M. C., Puccetti P., Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation. Journal of Immunology 2003 171 5 2581 2587 2-s2.0-0042930935 (Pubitemid 37025569)
56. Belz G. T., Heath W. R., Carbone F. R., The role of dendritic cell subsets in selection between tolerance and immunity. Immunology and Cell Biology 2002 80 5 463 468 2-s2.0-0036380917 10.1046/j.1440-1711.2002.01116.x
57. Garrovillo M., Ali A., Depaz H. A., Gopinathan R., Oluwole O. O., Hardy M. A., Oluwole S. F., Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells. American Journal of Transplantation 2001 1 2 129 137 2-s2.0-0035401095 (Pubitemid 33674152)
58. Kuo Y. R., Huang C. W., Goto S., Wang C. T., Hsu L. W., Lin Y. C., Yang K. D., Chen C. L., Lee W. P. A., Alloantigen-pulsed host dendritic cells induce T-cell regulation and prolong allograft survival in a rat model of hindlimb allotransplantation. Journal of Surgical Research 2009 153 2 317 325 2-s2.0-67349216663 10.1016/j.jss.2008.05.034
59. Sacks J. M., Kuo Y. R., Taieb A., Breitinger J., Nguyen V. T., Thomson A. W., Feili-Hariri M., Lee W. P. A., Prolongation of composite tissue allograft survival by immature recipient dendritic cells pulsed with donor antigen and transient low-dose immunosuppression. Plastic and Reconstructive Surgery 2008 121 1 37 49 2-s2.0-38049095528 10.1097/01.prs.0000293754.55706.7f
60. Horibe E. K., Sacks J., Unadkat J., Raimondi G., Wang Z., Ikeguchi R., Marsteller D., Ferreira L. M., Thomson A. W., Lee W. P. A., Feili-Hariri M., Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion. Transplant Immunology 2008 18 4 307 318 2-s2.0-37349068519 10.1016/j.trim.2007.10.007 (Pubitemid 350297967)
61. Ikeguchi R., Sacks J. M., Unadkat J. V., Solari M., Horibe E. K., Thomson A. W., Lee A. W. P., Feili-Hariri M., Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression. Transplantation 2008 85 2 237 246 2-s2.0-38549139467 10.1097/TP.0b013e31815e870e (Pubitemid 351156854)
62. + T regulatory cells and promote organ transplant tolerance. Journal of Immunology 2007 178 11 7018 7031 2-s2.0-34249805413 (Pubitemid 46847428)
63. Yu P., Xiong S., He Q., Chu Y., Lu C., Ramlogan C. A., Steel J. C., Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts. Immunology 2009 127 4 500 511 2-s2.0-67650432515 10.1111/j.1365-2567.2009.03057.x
64. Zahorchak A. F., Kean L. S., Tokita D., Turnquist H. R., Abe M., Finke J., Hamby K., Rigby M. R., Larsen C. P., Thomson A. W., Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation 2007 84 2 196 206 2-s2.0-34547627452 10.1097/01.tp.0000268582.21168.f6 (Pubitemid 47205753)
65. + regulatory T cells in vivo in humans. Blood 2002 100 1 174 177 2-s2.0-0036659913 10.1182/blood.V100.1.174 (Pubitemid 35177444)
66. Dhodapkar M. V., Steinman R. M., Krasovsky J., Munz C., Bhardwaj N., Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. Journal of Experimental Medicine 2001 193 2 233 238 2-s2.0-0035862333 10.1084/jem.193.2.233 (Pubitemid 32524454)
67. Thomson A. W., Sacks J. M., Kuo Y. R., Ikeguchi R., Horibe E. K., Unadkat J., Solari M. G., Feili-Hariri M., Lee W. P. A., Dendritic cell therapy in composite tissue allotransplantation. Transplantation Proceedings 2009 41 2 537 538 2-s2.0-62849108696 10.1016/j.transproceed.2009.01.011
68. Deans R. J., Moseley A. B., Mesenchymal stem cells: biology and potential clinical uses. Experimental Hematology 2000 28 8 875 884 2-s2.0-0033824164 10.1016/S0301-472X(00)00482-3
69. Dazzi F., Ramasamy R., Glennie S., Jones S. P., Roberts I., The role of mesenchymal stem cells in haemopoiesis. Blood Reviews 2006 20 3 161 171 2-s2.0-33646015065 10.1016/j.blre.2005.11.002
70. Majumdar M. K., Keane-Moore M., Buyaner D., Hardy W. B., Moorman M. A., McIntosh K. R., Mosca J. D., Characterization and functionality of cell surface molecules on human mesenchymal stem cells. Journal of Biomedical Science 2003 10 2 228 241 2-s2.0-0037221583 10.1159/000068710 (Pubitemid 36302404)
71. Glennie S., Soeiro I., Dyson P. J., Lam E. W. F., Dazzi F., Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 2005 105 7 2821 2827 2-s2.0-15944376184 10.1182/blood-2004-09-3696 (Pubitemid 40446275)
72. Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., Dazzi F., Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003 101 9 3722 3729 2-s2.0-0038204193 10.1182/blood-2002-07-2104 (Pubitemid 36857965)
73. Sbano P., Cuccia A., Mazzanti B., Urbani S., Giusti B., Lapini I., Rossi L., Abbate R., Marseglia G., Nannetti G., Torricelli F., Miracco C., Bosi A., Fimiani M., Saccardi R., Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model. Archives of Dermatological Research 2008 300 3 115 124 2-s2.0-39949084861 10.1007/s00403-007-0827-9
74. Bartholomew A., Sturgeon C., Siatskas M., Ferrer K., McIntosh K., Patil S., Hardy W., Devine S., Ucker D., Deans R., Moseley A., Hoffman R., Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Experimental Hematology 2002 30 1 42 48 2-s2.0-0036142769 10.1016/S0301-472X(01)00769-X (Pubitemid 34059216)
75. Ringdén O., Uzunel M., Rasmusson I., Remberger M., Sundberg B., Lönnies H., Marschall H. U., Dlugosz A., Szakos A., Hassan Z., Omazic B., Aschan J., Barkholt L., Le Blanc K., Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006 81 10 1390 1397 2-s2.0-33744913533 10.1097/01.tp.0000214462.63943.14 (Pubitemid 43847148)
76. Pan H., Zhao K., Wang L., Zheng Y., Zhang G., Mai H., Han Y., Yang L., Guo S., Mesenchymal stem cells enhance the induction of mixed chimerism and tolerance to rat hind-limb allografts after bone marrow transplantation. Journal of Surgical Research 2010 160 2 315 324 2-s2.0-77950918454 10.1016/j.jss.2008. 09.027
77. Kuo Y. R., Goto S., Shih H. S., Wang F. S., Lin C. C., Wang C. T., Huang E. Y., Chen C. L., Wei F. C., Zheng X. X., Lee W. P. A., Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009 87 12 1769 1777 2-s2.0-67649586583 10.1097/TP. 0b013e3181a664f1
78. Schneeberger S., Gorantla V. S., Brandacher G., Zeevi A., Demetris A. J., Lunz J. G., Metes D. M., Donnenberg A. D., Shores J. T., Dimartini A. F., Kiss J. E., Imbriglia J. E., Azari K., Goitz R. J., Manders E. K., Nguyen V. T., Cooney D. S., Wachtman G. S., Keith J. D., Fletcher D. R., Macedo C., Planinsic R., Losee J. E., Shapiro R., Starzl T. E., Lee W. P., Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. Annals of Surgery 2012 10.1097/SLA.0b013e31826d90bb
79. Bolaños-Meade J., Fuchs E. J., Luznik L., Lanzkron S. M., Gamper C. J., Jones R. J., Brodsky R. A., HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease. Blood 2012 120 22 4285 4291 10.1182/blood-2012-07-438408