Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts

Immunology

Volumn 127, Issue 4, 2009, Pages 500-511

  Yu, Ping ^a,b   Xiong, Sidong ^b   He, Qiuzao ^b   Chu, Yiwei ^b   Lu, Chi ^c   Ramlogan, Charmaine A ^a   Steel, Jason C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Allogeneic chimerism; Bone marrow transplantaton; Immature dendritic cells; Immune tolerance; Regulatory T cells

Indexed keywords

DENDRITIC CELL VACCINE; DOXORUBICIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CHIMERA; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; IMMUNOLOGICAL TOLERANCE; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION CHIMERA; REGULATORY T LYMPHOCYTE; SKIN ALLOGRAFT; TH2 CELL;

ANIMALS; BONE MARROW TRANSPLANTATION; CLONAL ANERGY; CYTOKINES; DENDRITIC CELLS; FEMALE; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED STRAINS; SKIN TRANSPLANTATION; T-LYMPHOCYTES, REGULATORY; TH2 CELLS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING;

EID: 67650432515     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03057.x     Document Type: Article

References (32)

1. Montoya JG, Giraldo LF, Efron B et al. Infectious complications among 620 consecutive heart transplant patients at Stanford University Medical Center. Clin Infect Dis 2001 33 : 629 40.
2. Dantal J, Soulillou JP. Immunosuppressive drugs and the risk of cancer after organ transplantation. N Engl J Med 2005 352 : 1371 3.
3. Yamazaki M, Pearson T, Brehm MA et al. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Am J Transplant 2007 7 : 1710 21.
4. Kawai T, Cosimi AB, Spitzer TR et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008 358 : 353 61.
5. Fudaba Y, Spitzer TR, Shaffer J et al. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant 2006 6 : 2121 33.
6. Lucey MR, Abdelmalek MF, Gagliardi R et al. A comparison of tacrolimus and cyclosporine in liver transplantation: effects on renal function and cardiovascular risk status. Am J Transplant 2005 5 : 1111 19.
7. Rao AS, Fontes P, Iyengar A et al. Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplantation recipients: a 44 month follow-up. Transplant Proc 1997 29 : 1184 5.
8. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
9. Thomson AW, Lu L. Dendritic cells as regulators of immune reactivity: implications for transplantation. Transplantation 1999 68 : 1 8. (Pubitemid 29352820)
10. Finkelman FD, Lees A, Birnbaum R, Gause WC, Morris SC. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol 1996 157 : 1406 14.
11. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM. Generation of larger numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992 176 : 1693 702.
12. Lu L, Rudert WA, Qian S et al. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in responses to granulocyte/macrophage colony-stimulating factor. J Exp Med 1995 182 : 379 87.
13. Lu L, Woo J, Rao AS et al. Propagation of dendritic cell progenitors from normal mouse liver using GM-CSF and their maturational development in the presence of type-I collagen. J Exp Med 1994 179 : 1823 34.
14. Wekerle T, Sykes M. Mixed chimerism and transplantation tolerance. Annu Rev Med 2001 52 : 353 70.
15. Judd KP, Trentin JJ. Cardiac transplantation in mice. I. Factors influencing the take and survival of heterotopic grafts. Transplantation 1971 11 : 298 302.
16. Eto M, Hackstein H, Kaneko K, Nomoto K, Thomson AW. Promotion of skin graft tolerance across MHC barriers by mobilization of dendritic cells in donor hemopoietic cell infusions. J Immunol 2002 169 : 2390 6.
17. Inaba K, Witmer-Pack M, Inaba M et al. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 1994 180 : 1849 60.
18. Nikolic B, Sykes M. Bone marrow chimerism and transplantation tolerance. Curr Opin Immunol 1997 9 : 634 40.
19. Freeman GJ, Borriello F, Hodes RJ et al. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 1993 262 : 907 9.
20. Ye WF, He QZ. Induction of prolongation of allograft survival by immunization with immature DCs. Chin J Immunol 2001 17 : 7 10.
21. Maksymowicz M, Olszewski WL, Gewartowska M, Kolakowska B. Recipient immature dendritic cells do not prolong allograft survival. Transplant Proc 2005 37 : 25 6.
22. Wang Q, Liu Y, Wang J et al. Induction of allospecific tolerance by immature dendritic cells genetically modified to express soluble TNF receptor. J Immunol 2006 177 : 2175 85.
23. Raimondi G, Thomson AW. Dendritic cells, tolerance and therapy of organ allograft rejection. Contrib Nephrol 2005 146 : 105 20.
24. Field EH, Rouse T. Requirement for developing mixed-chimerism in nonmyeloablative total-lymphoid irradiated mice: role of IL-4 and immunoredirection. Transplantation 2002 74 : 1021 9.
25. Weiden PL. Allogeneic bone marrow transplantation. Crit Rev Clin Lab Sci 1983 19 : 173.
26. Sykes M. Mixed chimerism and transplant tolerance. Immunity 2001 14 : 417 24.
27. Cobbold SP. Regulatory T cells and transplantation tolerance. J Nephrol 2008 21 : 485 96.
28. Cottrez F, Hurst SD, Coffman RL, Groux H. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000 165 : 4848 53.
29. Hara M, Kingsley CI, Niimi M et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001 166 : 3789 96.
30. Perrin GQ, Johnson HM, Subramaniam PS. Mechanism of interleukin-10 inhibition of T helper cell activation by superantigen at the level of the cell cycle. Blood 1999 93 : 208 16.
31. Mottram PL, Han WR, Purcell LJ, McKenzie IFC, Hancock WW. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4- monoclonal antibody therapy. Transplantation 1995 59 : 559 65.
32. Chen Y, Chen J, Liu Z et al. Relationship between TH1/TH2 cytokines and immune tolerance in liver transplantation in rats. Transplant Proc 2008 40 : 2691 5.