Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression

Annals of Surgery

Volumn 257, Issue 2, 2013, Pages 345-351

  Schneeberger, Stefan ^a,b,e   Gorantla, Vijay S ^a   Brandacher, Gerald ^a,b,e   Zeevi, Adriana ^c   Demetris, Anthony J ^c   Lunz, John G ^c   Metes, Diana M ^a   Donnenberg, Albert D ^c   Shores, Jaimie T ^b   Dimartini, Andrea F ^c   Kiss, Joseph E ^c   Imbriglia, Joseph E ^a   Azari, Kodi ^d   Goitz, Robert J ^d   Manders, Ernest K ^a   Nguyen, Vu T ^a   Cooney, Damon S ^a   Wachtman, Galen S ^a   Keith, Jonathan D ^a   Fletcher, Derek R ^a   MacEdo, Camila ^a   Planinsic, Raymond ^a   Losee, Joseph E ^a   Shapiro, Ron ^a   Starzl, Thomas E ^a   Lee, W P Andrew ^a,b   more..

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

bone marrow; cell therapy; composite tissue allotransplantation; hand transplantation; immunomodulation; immunomonitoring; immunosuppression; reconstructive transplantation; rejection; vascularized composite allotransplantation

Indexed keywords

ALEMTUZUMAB; ALLOANTIBODY; COTRIMOXAZOLE; CREATININE; METHYLPREDNISOLONE; TACROLIMUS;

ADULT; ANTIBIOTIC PROPHYLAXIS; ARM AMPUTATION; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL THERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; DISABLED PERSON; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; GRAFT PATENCY; GRAFT REJECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERURICEMIA; IMMUNOCOMPETENCE; IMMUNOLOGICAL MONITORING; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MONOTHERAPY; MOTOR PERFORMANCE; PLASTIC SURGERY; PRIORITY JOURNAL; SKIN BIOPSY; SURGICAL INFECTION; TRANSPLANTATION; UPPER EXTREMITY TRANSPLANTATION;

ADULT; BONE MARROW TRANSPLANTATION; FEMALE; FOREARM; HAND; HUMANS; IMMUNE TOLERANCE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE AGENTS; MALE; TACROLIMUS; YOUNG ADULT;

EID: 84872290207     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e31826d90bb     Document Type: Article

References (36)

1. Petruzzo P, Lanzetta M, Dubernard JM, et al. The international registry on hand and composite tissue transplantation. Transplantation. 2010;90:1590-1594.
2. Starzl TE, Zinkernagel R. Antigen localization and migration in immunity and tolerance. N Engl J Med. 1998;339:1905-1913.
3. Starzl TE, Murase N, Abu-Elmagd K, et al. Tolerogenic immunosuppression for organ transplantation. Lancet 2003;361:1502-1510.
4. Starzl TE, Zinkernagel R. Transplantation tolerance from a historical perspective. Nat Rev Immunol. 2001;1:233-239.
5. Starzl TE. Acquired immunologic tolerance: with particular reference to transplantation. Immunol Res. 2007;38:6-41.
6. Fontes P, Rao AS, Demetris AJ, et al. Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation. Lancet. 1994;344:151-155.
7. Ciancio G, Miller J, Garcia-Morales RO, et al. Six-year clinical effect of donor bone marrow infusions in renal transplant patients. Transplantation. 2001;71:827-835.
8. Hettiaratchy S, Melendy E, Randolph MA, et al. Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation. 2004;77:514-521.
9. Gorantla VS, Schneeberger S, Moore LR, et al. Development and validation of a procedure to isolate viable bone marrow cells from the vertebrae of cadaveric organ donors for composite organ grafting. Cytotherapy. 2012;1:104-113.
10. Donnenberg AD, Gorantla VS, Schneeberger S, et al. Clinical implementation of a procedure to prepare bone marrow cells from cadaveric vertebral bodies. Regen Med. 2011;6:701-706.
11. Cendales LC, Kanitakis J, Schneeberger S, et al. The Banff 2007 working classification of skin-containing composite tissue allograft pathology. Am J Transplant. 2008;8:1396-1400.
12. Myredal A, Gan LM, Osika W, et al. Increased intima thickness of the radial artery in individuals with prehypertension and hypertension. Atherosclerosis. 2010;209:147-151.
13. Dubernard JM, Lengelé B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med. 2007;357:2451-2460.
14. Delis S, Ciancio G, Burke GW, III, et al. Donor bone marrow transplantation: chimerism and tolerance. Transpl Immunol. 2004;13:105-115.
15. Macedo C, Orkis E, Elinoff B, et al. Long-term effect of alemtuzumab induction on T cell memory and T regulatory cell (Treg) subsets in kidney transplant recipients. Am J Transplant. 2010;10:489.
16. Macedo C, Orkis EA, Popescu I, et al. Contribution of naïve and memory T cell populations to the human alloimmune response. Am J Transplant. 2009;9:2057-2066.
17. Trzonkowski P, Zilvetti M, Chapman S, et al. Homeostatic repopulation by CD28-CD8 +T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression. Am J Transplant. 2008;8:338-347.
18. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med. 2003;349:2326-2333.
19. Barber WH, Mankin JA, Laskow DA, et al. Long-term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients. Transplantation. 1991;51:70-75.
20. Kaufman CL, Breidenbach W. World experience after more than a decade of clinical hand transplantation: update from the Louisville hand transplant program. Hand Clin. 2011;4:417-421.
21. Tan HP, Donaldson J, Basu A, et al. Two hundred living donor kidney transplantations under alemtuzumab induction and tacrolimus monotherapy: 3-year follow-up. Am J Transplant. 2009;2:355-366.
22. Thomas PG, Woodside KJ, Lappin JA, et al. Alemtuzumab (campath 1H) induction with tacrolimus monotherapy is safe for high immunological risk renal transplantation. Transplantation. 2007;11:1509-1512.
23. Shapiro R, Ellis D, Tan HP, et al. Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation. Am J Transplant. 2007;12:2736-2738.
24. Margreiter R, Klempnauer J, Neuhaus P, et al. Alemtuzumab (campath-1H) and tacrolimus monotherapy after renal transplantation: results of a prospective randomized trial. Am J Transplant. 2008;7:1480-1485.
25. Chan K, Taube D, Roufosse C, et al. Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy-an open label, randomized trial. Transplantation. 2011;7:774-780.
26. Tan HP, Donaldson J, Ellis D, et al. Pediatric living donor kidney transplantation under alemtuzumab pretreatment and tacrolimus monotherapy: 4-year experience. Transplantation. 2008;12:1725-1731.
27. Watson CJ, Bradley JA, Friend PJ, et al. Alemtuzumab (campath 1H) induction therapy in cadaveric kidney transplantation-efficacy and safety at five years. Am J Transplant. 2005;6:1347-1353.
28. Willicombe M, Brookes P, Santos-Nunez E, et al. Outcome of patients with preformed donor-specific antibodies following alemtuzumab induction and tacrolimus monotherapy. Am J Transplant. 2011;3:470-477.
29. Corry RJ, Chakrabarti PK, Shapiro R, et al. Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients. Ann Surg. 1999;230:372-379.
30. Pham SM, Rao AS, Zeevi A, et al. A clinical trial combining donor bone marrow infusion and heart transplantation: intermediate-term results. J Thorac Cardiovasc Surg. 2000;119:673-681.
31. Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med. 2008;358:362-368.
32. Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008;358:353-361.
33. Siemionow M, Klimczak A, Unal S, et al. Hematopoietic stem cell engraftment and seeding permits multi-lymphoid chimerism in vascularized bone marrow transplants. Am J Transplant. 2008;8:1163-1176.
34. Arslan E, Klimczak A, Siemionow M. Chimerism induction in vascularized bone marrow transplants augmented with bone marrow cells. Microsurgery. 2007;27:190-199.
35. Schneeberger S, Gorantla VS, van Riet RP, et al. Atypical acute rejection after hand transplantation. Am J Transplant. 2008;8:688-696.
36. Gremigni P, Bacchi F, Turrini C, et al. Psychological factors associated with medication adherence following renal transplantation. Clin Transplant. 2007;6:710-715.