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Bioorganic Chemistry

Volumn 30, Issue 4, 2002, Pages 264-275

pH dependence of inhibitors targeting the occluding loop of cathepsin B

(4) Cathers, Brian E a Barrett, Cynthia a Palmer, James T a Rydzewski, Robert M a

a NewBiotics Inc (United States)

Author keywords

CA 074; Cancer; Cathepsin B; E 64; Inhibitor; Occluding loop; pH

Indexed keywords

APC 3316; APC 5840; APC 8754; CA 030; CA 074; CARBOXYLIC ACID; CATHEPSIN B; HISTIDINE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; APC-5840; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE; DRUG DERIVATIVE; LEUCINE; N (CHLOROACETYL) LEUCYLPROLIN TERT BUTYL ESTER; N-(CHLOROACETYL)-LEUCYLPROLIN-TERT-BUTYL ESTER; PIPERAZINE DERIVATIVE; SULFONE;

ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; INHIBITION KINETICS; IONIZATION; PH; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; LIVER; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; CATHEPSIN B; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; DRUG DESIGN; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LEUCINE; LIVER; PIPERAZINES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; SULFONES;

EID: 0036702638 PISSN: 00452068 EISSN: None Source Type: Journal
DOI: 10.1016/S0045-2068(02)00009-3 Document Type: Article

Times cited : (19)

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