An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1

Molecular Pharmacology

Volumn 83, Issue 2, 2013, Pages 481-489

  Yang, Tao ^a   Smith, Jarrod A ^a   Leake, Brenda F ^a   Sanders, Charles R ^a   Meiler, Jens ^a   Roden, Dan M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTEINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.5; QUINIDINE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG BINDING; MOLECULAR DOCKING; MONTE CARLO METHOD; PRIORITY JOURNAL; WILD TYPE;

ALANINE; ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CYSTEINE; HEART; HUMANS; KCNQ1 POTASSIUM CHANNEL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MYOCARDIUM; QUINIDINE;

EID: 84872738420     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.081513     Document Type: Article

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