PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 47, 2009, Pages 20075-20080

  Perry, Matthew ^a,b   Sachse, Frank B ^b,c   Abbruzzese, Jennifer ^a,b   Sanguinetti, Michael C ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Department of Electrical and Computer Engineering   (United States)

Author keywords

Activator; Potassium channel; Voltage clamp

Indexed keywords

[2 (4 [2 (3,4 DICHLORO PHENYL) ETHYL] PHENYLAMINO) BENZOIC ACID; BENZOIC ACID DERIVATIVE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL HERG 1; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; GENE MUTATION; HYDROPHOBICITY; MUTAGENESIS; MUTANT; NONHUMAN; OOCYTE; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; WILD TYPE; XENOPUS;

ANIMALS; ANTHRANILIC ACIDS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MUTAGENESIS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; XENOPUS LAEVIS;

EID: 73949151507     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906597106     Document Type: Article

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