Oral supplementation with antioxidant agents containing alpha lipoic acid: Effects on postmenopausal bone mass

Clinical and Experimental Obstetrics and Gynecology

Volumn 39, Issue 4, 2012, Pages 489-493

  Mainini, G ^a   Rotondi, M ^b   Di Nola, K ^c   Pezzella, M T ^c   Iervolino, S A ^c   Seguino, E ^c   D'Eufemia, D ^c   Iannicelli, I ^c   Torella, M ^c  

^a Ospedale S Leonardo   (Italy)

^b Azienda Sanitaria Locale (ASL)   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Alpha lipoic acid; Menopause; Osteoporosis

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CALCIUM; COLECALCIFEROL; SELENIUM; THIOCTIC ACID;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MASS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; OSTEOLYSIS; OSTEOPENIA; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PROSPECTIVE STUDY;

EID: 84872712841     PISSN: 03906663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Bitar M.S., Wahid S., Pilcher C.W., Al-Saleh E., Al-Mulla F.: "Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats". Horm. Metab. Res., 2004, 36, 542.
2. Haugaard N., Levin R.M.: "Regulation of the activity of choline acetyl transferase by lipoic acid". Mol. Cell. Biochem., 2000, 213, 61.
3. Packer L., Witt E.H., Tritschler H.J.: "Alpha-lipoic acid as a biological antioxidant". Free Radic. Biol. Med., 1995, 19, 227.
4. Nguyen T., Yang C.S., Pickett C.B.: "The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress". Free Radic. Biol. Med., 2004, 37, 433.
5. Chen X.L., Kunsch C.: "Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases". Curr. Pharm. Des., 2004, 10, 879.
6. Huang X., Atwood C.S., Hartshorn M.A., Multhaup G., Goldstein L.E., Scarpa R.C. et al.: "The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction". Biochemistry, 1999, 38, 7609.
7. Suh J.H., Shenvi S.V., Dixon B.M., Liu H., Jaiswal A.K., Liu R.M. et al.: "Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid". Proc. Natl. Acad. Sci USA, 2004, 101, 3381.
8. Suh J.H., Zhu B.Z., deSzoeke E., Frei B., Hagen T.M.: "Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes". Redox Rep., 2004, 9, 57.
9. Suh J.H., Moreau R., Heath S.H., Hagen T.M.: "Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex". Redox Rep., 2005, 10, 52.
10. Fonte J., Miklossy J., Atwood C., Martins R.: "The severity of cortical Alzheimer's type changes is positively correlated with increased amyloid-beta levels: resolubilization of amyloid-beta with transition metal ion chelators". J. Alzheimers Dis., 2001, 3, 209.
11. Quinn J.F., Bussiere J.R., Hammond R.S., Montine T.J., Henson E., Jones R.E. et al.: "Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice". Neurobiol. Aging, 2007, 28, 213.
12. Griffin W.S., Sheng J.G., Roberts G.W., Mrak R.E.: "Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution". J. Neuropathol. Exp. Neurol., 1995, 54, 276.
13. Lander H.M., Tauras J.M., Ogiste J.S., Hori O., Moss R.A., Schmidt A.M.: "Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress". J. Biol. Chem., 1997, 272, 17810.
14. Pocernich C.B., Butterfield D.A.: "Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease". Neurotox. Res., 2003, 5, 515.
15. Arivazhagan P., Ramanathan K., Panneerselvam C.: "Effect of DL-alpha-lipoic acid on glutathione metabolic enzymes in aged rats". Exp. Gerontol., 2001, 37, 81.
16. Simonian N.A., Coyle J.T.: "Oxidative stress in neurodegenerative diseases". Ann. Rev. Pharmacol. Toxicol., 1996, 36, 83.
17. Shay K.P., Moreau R.F., Smith E.J., Smith A.R., Hagen T.M.: "Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential". Biochim. Biophys. Acta, 2009, 1790, 1149.
18. Romero F.J., Ordonez I., Arduini A., Cadenas E.: "The reactivity of thiols and disulfides with different redox states of myoglobin. Redox and addition reactions and formation of thiyl radical intermediates". J. Biol. Chem., 1992, 267, 1680.
19. Jacob S., Streeper R.S., Fogt D.L., Hokama J.Y., Tritschler H.J., Dietze G.J. et al.: "The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle". Diabetes, 1996, 45, 1024.
20. Fuchs J., Schofer H., Milbradt R., Freisleben H.J., Buhl R., Siems W. et al.: "Studies on lipoate effects on blood redox state in human immunodeficiency virus infected patients". Arzneimittelforschung, 1993, 43, 1359.
21. Packer L., Tritsschler H., Wessel K.: "Neuroprotection by the metabolic antioxidant alpha-lipoic acid". Free Rad. Biol. Med., 1997, 22, 359.
22. Lean J.M., Davies J.T., Fuller K., Jagger C.J., Kirstein B., Partington G.A. et al.: "A crucial role for thiol antioxidants in estrogen-deficiency bone loss". J. Clin. Invest., 2003, 112, 915.
23. Lean J., Kirstein B., Urry Z., Chambers T., Fuller K.: "Thioredoxin-1 mediates osteoclast stimulation by reactive oxygen species". Biochem. Biophys Res. Commun., 2004, 321, 845.
24. Lean J.M., Jagger C.J., Kirstein B., Fuller K., Chambers T.J.: "Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation". Endocrinology 2005, 146, 728.
25. Maggio D., Barabani M., Pierandrei M., Polidori M.C., Catani M., Mecocci P. et al.: "Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study". J. Clin. Endocrinol. Metab., 2003, 88, 1523.
26. Grassi F., Tell G., Robbie-Ryan M., Gao Y., Terauchi M., Yang X. et al.: "Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation". Proc. Natl. Acad. Sci. USA, 2007, 104, 15087.
27. Ilich J.Z., Brownbill R.A., Tamborini L.: "Bone and nutrition in elderly women: Protein, energy, and calcium as main determinants of bone mineral density". Eur. J. Clin. Nutr., 2003, 57, 554.
28. Macdonald H.M., New S.A., Golden M.H., Campbell M.K., Reid D.M.: "Nutritional associations with bone loss during the menopausal transition: Evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids". Am. J. Clin. Nutr., 2004, 79, 155.
29. Melhus H., Michaelsson K., Holmberg L., Wolk A., Ljunghall S.: "Smoking, antioxidant vitamins, and the risk of hip fracture". J. Bone Miner. Res., 1999, 14, 129.
30. Weber P.: "The role of vitamins in the prevention of osteoporosis - a brief status report". Int. J. Vitam. Nutr. Res., 1999, 69, 194.
31. Hall S.L., Greendale G.A.: "The relation of dietary vitamin C intake to bone mineral density: Results from the PEPI study". Calcif Tissue Int., 1998, 63, 183.
32. Patrick L.: "Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity". Altern. Med. Rev., 2003, 8, 106.
33. Kurokouchi K., Kambe F., Yasukawa K., Izumi R., Ishiguro N., Iwata H. et al.: "TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells". J. Bone Miner. Res., 1998, 13, 1290.
34. Byun C.H., Koh J.M., Kim D.K., Park S.I., Lee K.U., Kim G.S.: "Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells". J. Bone Miner. Res., 2005, 20, 1125.
35. Luisetto G., Zangari M., Tizian L., Nardi A., Ramazzina E., Adami S. et al:. "Influence of aging and menopause in determining vertebral and distal forearm bone loss in adult healthy women". Bone Miner., 1993, 22, 9.
36. Riggs B.L., Khosla S., Melton L.J. III: "A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men". J. Bone Miner. Res., 1998, 13, 763.
37. Jagger C.J., Lean J.M., Davies J.T., Chambers T.J.: "Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants". Endocrinology, 2005, 146, 113.
38. Smith A.R., Shenvi S.V., Widlansky M., Suh J.H., Hagen T.M.: "Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress". Curr. Med. Chem., 2004, 11, 1135.
39. Liu J., Head E., Gharib A.M., Yuan W., Ingersoll R.T., Hagen T.M. et al.: "Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or (R)-alpha-lipoic acid". Proc. Natl. Acad. Sci USA, 2002, 99, 2356.
40. Lodge J.K., Traber M.G., Packer L.: "Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation". Free Radic. Biol. Med., 1998, 25, 287.
41. Anuradha B., Varalakshmi P.: "Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation". Pharmacol. Res., 1999, 39, 67.
42. Han D., Sen C.K., Roy S., Kobayashi M.S., Tritschler H.J., Packer L.: "Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants". Am. J. Physiol., 1997, 273, R1771.
43. Holmquist L., Stuchbury G., Berbaum K., Muscat S., Young S., Hager K. et al.: "Lipoic acid as a novel treatment for Alzheimer's disease and related dementias". Pharmacol. Ther., 2007, 113, 154.
44. Reljanovic M., Reichel G., Rett K., Lobisch M., Schuette K., Moller W. et al.: "Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy". Free Radic. Res., 1999, 31, 171.
45. Ziegler D., Nowak H., Kempler P., Vargha P., Low P.A.: "Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis". Diabet. Med., 2004, 21, 114.
46. Ziegler D., Ametov A., Barinov A., Dyck P.J., Gurieva I., Low P.A. et al.: "Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial". Diabetes Care, 2006, 29, 2365.
47. Midaoui A., de Champlain J.: "Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid". Hypertension, 2002, 39, 303.
48. Kim M.S., Park J.Y., Namkoong C., Jang P.G., Ryu J.W., Song H.S. et al.: "Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase". Nat. Med., 2004, 10, 727.
49. Koh J.M., Lee Y.S., Byun C.H., Chang E.J., Kim H., Kim Y.H. et al.: "Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells". J. Endocrinol., 2005, 185, 401.
50. Kim H.J., Chang E.J., Kim H.M., Lee S.B., Kim H.D., Su Kim G., et al.: "Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha". Free Radicol. Biol. Med., 2006, 40, 1483.
51. Morikawa T., Yasuno R., Wada H.: "Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria". FEBS Lett., 2001, 498, 16.
52. Langton C.M., Langton D.K.: "Male and female reference data for ultrasound measurement of the calcaneus within the UK adult population". Br. J. Radiol., 1997, 70, 580.
53. Ingle B.M., Sherwood K.E., Eastell R.: "Comparison of two methods for measuring ultrasound properties of the heel in postmenopausal women". Osteoporos. Int., 2001, 12, 500.
54. Louis O., Kaufman L., Osteaux M.: "Quantitative ultrasound of the calcaneus with parametric imaging: correlation with bone mineral density at different sites and with anthropometric data in menopausal women". Eur. J. Radiol., 2000, 35, 65.
55. Von Stetten E., Ouellet H., Wilson K., Steiger P., Stein J.A.: "European caucasian female reference values for the Sahara clinical bone sonometer". Bedford (USA), Hologic Inc., 1998.
56. Ponteggia L., Di Cato M., Ponteggia F., Pica M., Puxeddu A., Coaccioli S.: "Evaluation of the peak bone mass by quantitative heel ultrasound in young women of the centre of Italy". Reumatismo, 2003, 55, 34.
57. He Y.Q., Fan B., Hans D., Li J., Wu C.Y., Njeh C.F. et al.: "Assessment of a new quantitative ultrasound calcaneus measurement: precision and discrimination of hip fractures in elderly women compared with dual X-ray absorptiometry". Osteoporos. Int., 2000, 11, 354.
58. Adami S., Bertoldo F., Brandi M.L., Cepollaro C., Filipponi P., Fiore E. et al.: "Guidelines for the diagnosis, prevention and treatment of osteoporosis". Reumatismo, 2009, 61, 260.
59. Cummings S.R., Bates D., Black D.M.: "Clinical use of bone densitometry: scientific review". JAMA, 2002, 288, 1889.
60. Lee S.H., Kim M.J., Kim B.J., Kim S.R., Chun S., Ryu J.S. et al.: "Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson's disease". Mov. Disord., 2010, 25, 332.
61. Wolf R.L., Cauley J.A., Pettinger M., Jackson R., Lacroix A., Leboff M.S. et al.: "Lack of a relation between vitamin and mineral antioxidants and bone mineral density: results from the Women's Health Initiative". Am. J. Clin. Nutr., 2005, 82, 581.